iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053861

UUCD1 version

UUC-LoA-00510

Ensembl Protein ID

ENSLAFP00000012269.3

UniProt Accession

G3TDL7; G3TDL7_LOXAF

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014645.3	ENSLAFT00000014648.3	ENSLAFP00000012269.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-59	195.3	656	693
UBD/Beta-Prp	4.20e-90	302.3	610	797

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           H+d+v c+af  +d++++++s D+++k+WD  tg l++
   Q: 656  HEDEVLCCAFsaDDRFIATCSVDKQVKIWDSVTGELVR 693
           ***********777******************999887 PP

UBD/Beta-Prp

   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           +++ h+d v+   fs++g++++s ++d+t++v++ etg++l e+++ +d+ v c +++ d++ ++++s D++v++Wd+ tg+l+rt  +
   Q: 610  VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDE-VLCCAFSADDRFIATCSVDKQVKIWDSVTGELVRTYDE 697
           56779************************************966666665.555566777999************************98 PP
   S: 178  ghtdsvyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiri.Wdlrsgdllktlqlh 263
            h ++v++  f+ ng    l++gs d  +klwdl ++ec +t+ ght+ v+  rfsp+d++l+s+s+Dgs++  Wd+rs +  k+++ +
   Q: 698  -HSEQVNCCHFTNNGhhLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDTLLASCSADGSLKKlWDVRSANERKSINVK 785
           .**************4444679*************************************************866*******99999998 PP
   S: 264  n..........s 265
           +          +
   Q: 786  QhfpdsedpqeD 797
           866655555442 PP

Organism

Loxodonta africana

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALERDI KTAYIMDHMI SDGVLTLLEE EKVKIEPTQQ QRAAMLIKMI 60
LQKDNYSYIS FYNALLHEGY RDLADRLRGG LPDVSSSNGK DSVGGITSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCAA AAGCTCGAAA TTGTTTACTT CAACACAGAG AAGCCCTGGA AAGAGACATC 60
AAGACAGCCT ATATCATGGA TCACATGATT AGTGATGGAG TTTTAACATT ATTGGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	90.26	0.00e+00	2307.00
IUUC-Apl-004201	Anas platyrhynchos	70.53	0.00e+00	1817.00
IUUC-Aca-004638	Anolis carolinensis	68.50	0.00e+00	1817.00
IUUC-Ani-009285	Aspergillus nidulans	26.04	2.00e-70	261.00
IUUC-Ame-011062	Astyanax mexicanus	55.34	0.00e+00	1379.00
IUUC-Bta-012865	Bos taurus	90.08	0.00e+00	2341.00
IUUC-Cja-018815	Callithrix jacchus	80.69	0.00e+00	2034.00
IUUC-Cfa-020222	Canis familiaris	85.83	0.00e+00	2180.00
IUUC-Cpo-021524	Cavia porcellus	87.36	0.00e+00	2244.00
IUUC-Csa-023861	Chlorocebus sabaeus	91.11	0.00e+00	2335.00
IUUC-Cho-024484	Choloepus hoffmanni	79.74	0.00e+00	1206.00
IUUC-Dre-028006	Danio rerio	54.00	0.00e+00	1276.00
IUUC-Dno-029591	Dasypus novemcinctus	90.96	0.00e+00	2365.00
IUUC-Dor-030237	Dipodomys ordii	75.42	0.00e+00	1073.00
IUUC-Ete-032620	Echinops telfairi	85.19	0.00e+00	1091.00
IUUC-Eca-033569	Equus caballus	90.00	0.00e+00	2321.00
IUUC-Eeu-035354	Erinaceus europaeus	65.42	2.00e-179	622.00
IUUC-Fca-036337	Felis catus	90.57	0.00e+00	2352.00
IUUC-Fal-037077	Ficedula albicollis	70.24	0.00e+00	1808.00
IUUC-Gmo-039687	Gadus morhua	50.39	0.00e+00	911.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.46	7.00e-41	163.00
IUUC-Gga-040299	Gallus gallus	69.25	0.00e+00	1830.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.39	0.00e+00	1280.00
IUUC-Ggo-045563	Gorilla gorilla	91.19	0.00e+00	2337.00
IUUC-Hsa-046771	Homo sapiens	90.87	0.00e+00	2331.00
IUUC-Lch-050200	Latimeria chalumnae	65.37	0.00e+00	1646.00
IUUC-Loc-052090	Lepisosteus oculatus	59.70	0.00e+00	1524.00
IUUC-Mcc-055543	Macaca mulatta	91.67	0.00e+00	2346.00
IUUC-Meu-056688	Macropus eugenii	80.61	0.00e+00	2046.00
IUUC-Mga-059243	Meleagris gallopavo	69.62	0.00e+00	1837.00
IUUC-Mmr-061134	Microcebus murinus	85.33	0.00e+00	1979.00
IUUC-Mdo-062913	Monodelphis domestica	79.81	0.00e+00	2066.00
IUUC-Mmu-063811	Mus musculus	86.80	0.00e+00	2270.00
IUUC-Mpu-066780	Mustela putorius furo	90.01	0.00e+00	2291.00
IUUC-Mlu-067276	Myotis lucifugus	89.69	0.00e+00	2326.00
IUUC-Nfi-068459	Neosartorya fischeri	27.10	3.00e-59	224.00
IUUC-Nle-069129	Nomascus leucogenys	90.63	0.00e+00	2322.00
IUUC-Opr-071007	Ochotona princeps	66.39	0.00e+00	1107.00
IUUC-Ont-071348	Oreochromis niloticus	54.81	0.00e+00	1399.00
IUUC-Oan-072717	Ornithorhynchus anatinus	80.91	0.00e+00	2128.00
IUUC-Ocu-074286	Oryctolagus cuniculus	90.23	0.00e+00	1971.00
IUUC-Ola-086895	Oryzias latipes	50.41	0.00e+00	1188.00
IUUC-Oga-088678	Otolemur garnettii	90.39	0.00e+00	2314.00
IUUC-Oar-089359	Ovis aries	89.68	0.00e+00	2317.00
IUUC-Ptr-091062	Pan troglodytes	90.79	0.00e+00	2328.00
IUUC-Pan-092528	Papio anubis	93.26	0.00e+00	1384.00
IUUC-Psi-093430	Pelodiscus sinensis	74.18	0.00e+00	1930.00
IUUC-Pma-094690	Petromyzon marinus	38.93	5.00e-153	535.00
IUUC-Pfo-097204	Poecilia formosa	54.52	0.00e+00	1376.00
IUUC-Pab-097690	Pongo abelii	91.35	0.00e+00	2339.00
IUUC-Pca-100778	Procavia capensis	72.24	0.00e+00	1205.00
IUUC-Pva-102870	Pteropus vampyrus	87.54	0.00e+00	2084.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	26.92	8.00e-61	229.00
IUUC-Rno-104889	Rattus norvegicus	86.72	0.00e+00	2234.00
IUUC-Sha-107465	Sarcophilus harrisii	79.84	0.00e+00	2102.00
IUUC-Sar-113268	Sorex araneus	88.64	0.00e+00	657.00
IUUC-Ssc-115654	Sus scrofa	89.68	0.00e+00	2330.00
IUUC-Tgu-117302	Taeniopygia guttata	70.48	0.00e+00	1826.00
IUUC-Tru-118363	Takifugu rubripes	54.41	0.00e+00	1381.00
IUUC-Tsy-119007	Tarsius syrichta	86.39	0.00e+00	2212.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.19	0.00e+00	1327.00
IUUC-Tbe-127413	Tupaia belangeri	76.81	0.00e+00	1397.00
IUUC-Ttr-129213	Tursiops truncatus	84.63	0.00e+00	2155.00
IUUC-Vpa-130146	Vicugna pacos	84.53	0.00e+00	1611.00
IUUC-Xtr-132559	Xenopus tropicalis	61.69	0.00e+00	1562.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence