iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107465

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AEFK01191722

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011224.1	ENSSHAT00000013234.1	ENSSHAP00000013128.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.00e-64	209.2	656	694
UBD/Beta-Prp	2.50e-93	312.7	962	1240

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           H+d+v c+af  +d++++++s D+++k+W+ rtg+l+++
   Q: 656  HEDDVLCCAFskDDRFIATCSVDKKVKIWNSRTGDLVHT 694
           ***********666*********************9885 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           l +++ks+i+c + spd +++a g +dg++k+ ++ +g  +rs  ghe++v+ v+f +dg +l+++s+D t++vw+  + + ++ lk
   Q: 962  LTEAQKSRISCCCLSPDLRYVALGEEDGSVKILELPNGREFRSRMGHEKAVRRVQFTSDGRTLISSSDDSTVQVWNWHSEE-FVFLK 1047
           56899***********************************************************************98766.67899 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           +h++ v + ++ + ++ l++ s d t++vw++ tg++ +  +  h+g+v +  ++pd+  + s+s+D+t ++W+ ++ + l++l+g 
   Q: 1048 AHQEPVKDFRLLQ-NSQLLTWSFDGTVKVWNILTGKVEK-DFVCHQGTVLSCDISPDATKFSSASADKTAKIWSFESHSPLHELRG- 1131
           9************.899*********************9.999******************************************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
           h++ v++  f+ ++  l++g+++g +++w+++tg+ ++++   t          +v+++rfsp++  lvs++    ++ W++++g+ 
   Q: 1132 HEGCVRCSVFSGDSALLATGDDNGEIRIWNVSTGQRLHSCVPVTvekgetafvGWVTDLRFSPDSRTLVSAG--AYLKWWNVDTGES 1216
           ************************************99988888888899999*******************..89*********** PP
   S: 257  lktlqlhnssvisvavlsfgdnvlv 281
           l+t+    +++  + v s++ + +v
   Q: 1217 LQTFYTNGTNLKTIHV-SPSFKTYV 1240
           ***9887766666665.55555544 PP

Organism

Sarcophilus harrisii

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

RMDAKAWNCL LQHKEALERD IKTSYLMDHM ISDRALSLSE EEKIRDQPTQ KKRAAMLIRV 60
LLEKDNNSYI SFYNALLHEG YKDLAFLLQD GIPLSSHNGK DSADGVTSYV KTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCATGTTTG ACCGTCCTGA GAAGGAAGAT CAGCTTGGAG GAGGATGGAT GCCAAAGCTT 60
GGAACTGTTT GTTACAGCAC AAGGAAGCCC TGGAAAGAGA CATCAAGACT TCCTACCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	79.35	0.00e+00	2082.00
IUUC-Apl-004201	Anas platyrhynchos	69.75	0.00e+00	1823.00
IUUC-Aca-004638	Anolis carolinensis	67.75	0.00e+00	1799.00
IUUC-Ani-009285	Aspergillus nidulans	25.42	1.00e-65	245.00
IUUC-Ame-011062	Astyanax mexicanus	55.02	0.00e+00	1389.00
IUUC-Bta-012865	Bos taurus	79.22	0.00e+00	2107.00
IUUC-Cja-018815	Callithrix jacchus	71.85	0.00e+00	1845.00
IUUC-Cfa-020222	Canis familiaris	75.32	0.00e+00	1952.00
IUUC-Cpo-021524	Cavia porcellus	79.04	0.00e+00	2065.00
IUUC-Csa-023861	Chlorocebus sabaeus	79.12	0.00e+00	2092.00
IUUC-Cho-024484	Choloepus hoffmanni	69.74	0.00e+00	1083.00
IUUC-Dre-028006	Danio rerio	53.61	0.00e+00	1275.00
IUUC-Dno-029591	Dasypus novemcinctus	80.38	0.00e+00	2145.00
IUUC-Dor-030237	Dipodomys ordii	66.34	0.00e+00	971.00
IUUC-Ete-032620	Echinops telfairi	76.08	0.00e+00	982.00
IUUC-Eca-033569	Equus caballus	80.25	0.00e+00	2108.00
IUUC-Eeu-035354	Erinaceus europaeus	57.64	4.00e-161	562.00
IUUC-Fca-036337	Felis catus	79.46	0.00e+00	2115.00
IUUC-Fal-037077	Ficedula albicollis	70.29	0.00e+00	1830.00
IUUC-Gmo-039687	Gadus morhua	50.58	0.00e+00	944.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.96	2.00e-41	165.00
IUUC-Gga-040299	Gallus gallus	68.90	0.00e+00	1828.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.92	0.00e+00	1277.00
IUUC-Ggo-045563	Gorilla gorilla	79.38	0.00e+00	2095.00
IUUC-Hsa-046771	Homo sapiens	79.04	0.00e+00	2088.00
IUUC-Lch-050200	Latimeria chalumnae	64.29	0.00e+00	1628.00
IUUC-Loc-052090	Lepisosteus oculatus	59.22	0.00e+00	1507.00
IUUC-Laf-053861	Loxodonta africana	79.84	0.00e+00	2102.00
IUUC-Mcc-055543	Macaca mulatta	79.52	0.00e+00	2098.00
IUUC-Meu-056688	Macropus eugenii	92.11	0.00e+00	2357.00
IUUC-Mga-059243	Meleagris gallopavo	69.35	0.00e+00	1843.00
IUUC-Mmr-061134	Microcebus murinus	75.52	0.00e+00	1786.00
IUUC-Mdo-062913	Monodelphis domestica	89.39	0.00e+00	2320.00
IUUC-Mmu-063811	Mus musculus	78.25	0.00e+00	2087.00
IUUC-Mpu-066780	Mustela putorius furo	79.14	0.00e+00	2069.00
IUUC-Mlu-067276	Myotis lucifugus	79.08	0.00e+00	2100.00
IUUC-Nle-069129	Nomascus leucogenys	78.96	0.00e+00	2082.00
IUUC-Opr-071007	Ochotona princeps	59.60	0.00e+00	1001.00
IUUC-Ont-071348	Oreochromis niloticus	54.96	0.00e+00	1395.00
IUUC-Oan-072717	Ornithorhynchus anatinus	79.20	0.00e+00	2092.00
IUUC-Ocu-074286	Oryctolagus cuniculus	79.51	0.00e+00	1782.00
IUUC-Ola-086895	Oryzias latipes	51.23	0.00e+00	1214.00
IUUC-Oga-088678	Otolemur garnettii	79.36	0.00e+00	2086.00
IUUC-Oar-089359	Ovis aries	78.50	0.00e+00	2085.00
IUUC-Ptr-091062	Pan troglodytes	79.28	0.00e+00	2092.00
IUUC-Pan-092528	Papio anubis	83.22	0.00e+00	1268.00
IUUC-Psi-093430	Pelodiscus sinensis	73.43	0.00e+00	1928.00
IUUC-Pma-094690	Petromyzon marinus	40.10	1.00e-156	546.00
IUUC-Pfo-097204	Poecilia formosa	54.62	0.00e+00	1368.00
IUUC-Pab-097690	Pongo abelii	79.44	0.00e+00	2097.00
IUUC-Pca-100778	Procavia capensis	62.66	0.00e+00	1063.00
IUUC-Pva-102870	Pteropus vampyrus	77.64	0.00e+00	1892.00
IUUC-Rno-104889	Rattus norvegicus	77.53	0.00e+00	2038.00
IUUC-Sar-113268	Sorex araneus	77.68	3.00e-173	602.00
IUUC-Ssc-115654	Sus scrofa	79.68	0.00e+00	2124.00
IUUC-Tgu-117302	Taeniopygia guttata	70.13	0.00e+00	1834.00
IUUC-Tru-118363	Takifugu rubripes	55.27	0.00e+00	1386.00
IUUC-Tsy-119007	Tarsius syrichta	76.73	0.00e+00	2004.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.99	0.00e+00	1326.00
IUUC-Tbe-127413	Tupaia belangeri	66.89	0.00e+00	1249.00
IUUC-Ttr-129213	Tursiops truncatus	74.18	0.00e+00	1929.00
IUUC-Vpa-130146	Vicugna pacos	73.61	0.00e+00	1439.00
IUUC-Xtr-132559	Xenopus tropicalis	60.35	0.00e+00	1558.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence