iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sit-110157

Ensembl Protein ID

Si035133m

UniProt Accession

K4A8C7; K4A8C7_SETIT

Genbank Protein ID

KQK86441.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM003536

Gene Name

LOC101768106; SETIT_035133mg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Si035133m.g	Si035187m	Si035187m
Si035133m.g	Si035133m	Si035133m

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.10e-110	371.7	14	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitel 100
           YDRQ+r+wG+++q++l++a+ +l+++g++G+E lKnLvl+G+gs+tvvD+++ve s+l+++FL+++   g+++A++ + +l+eln+ v+++++ee + +l
   Q: 14   YDRQLRIWGDQGQAALENASLCLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEASDLGNNFLLDEGCLGQPRAKSICSFLQELNDAVKAKFVEETPATL 113
           **************************************************************************************************** PP
   S: 101  eeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehti 187
            ++++ Ff++f+vV++++ ++++ +k++++c++a++ li ++++Gl G vrv++k++ +++s++d   d++++ +P+ +lk++           ++++++
   Q: 114  IDTNPsFFSQFTVVIATQLPESSLLKLDDICRKANIVLIAARSYGLTGLVRVSVKEHCVIESKPDhflDDLRLHNPWAELKQFAKsidindkdpVVHKHT 213
           ***********************************************************************************88899999999****** PP
   S: 188  ewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............ 274
           +++v++  l+e++a +++++ +++s+ek+e+kd++++ + + deen++ea+e + k  a+  i + i+q++++ + ++v++s+++fw+            
   Q: 214  PYIVILVRLAEKWADAHDGNLPSTSQEKREFKDLIRAHMLNVDEENYKEAVESSYKVSATPGIRNeIQQIIDD-NSAEVNSSSTDFWIlvaalkefvane 312
           ************************************************************************9.77799********************* PP
   S: 275  ...............................................................sfcsnaealq...........vpekvekdeevvkasa 300
                                                                          +fc+na++l+           + + v + ++++++++
   Q: 313  gngelplegtipdmtslteyyvslqkiyqakaeadclamenrvkdilkrigrdpdsisrayikTFCKNARKLRvcryrsimeefSSPIVSEVQRYFTDED 412
           *************************************************************************666666655554588888899999998 PP
   S: 301  p.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfep 394
           +     +y+llra++r++++++r pg ++ e d+d +++l+taaa+   +++g+++  l++dli+e+++++ ++i+ ++a++gG+a+qEviK+v+++f+p
   Q: 413  YsyamnFYVLLRAVDRLAANYNRLPGIFDSEIDED-IPRLKTAAASVL-SEMGLSGaSLTEDLIAEMCRFGGAEIHAVAAFIGGVASQEVIKLVTKQFVP 510
           899999********************999999999.*********998.*************************************************** PP
   S: 395  lknfflfdae 404
           l+ +f+f+++
   Q: 511  LRGTFIFNGI 520
           *******986 PP

Organism

Setaria italica

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAGVVAEP KTKYDRQLRI WGDQGQAALE NASLCLLNCG PTGTEALKNL VLGGIGSVTV 60
VDGSKVEASD LGNNFLLDEG CLGQPRAKSI CSFLQELNDA VKAKFVEETP ATLIDTNPSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAAGTACC CACAGCGAAG AGAGCGCATC CGCCTCCCCT CCGCTACGCA GCCATGGCCG 60
CCGCCGGCGT CGTCGCGGAG CCCAAGACCA AGTACGATCG CCAGCTCAGG TAACCCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

sita:101768106

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	87.08	0.00e+00	938.00
IUUC-Aml-002333	Ailuropoda melanoleuca	44.24	3.00e-135	474.00
IUUC-Atr-002644	Amborella trichopoda	69.98	0.00e+00	759.00
IUUC-Apl-003446	Anas platyrhynchos	43.65	3.00e-124	437.00
IUUC-Aca-004450	Anolis carolinensis	42.51	3.00e-129	454.00
IUUC-Aly-005466	Arabidopsis lyrata	67.56	0.00e+00	776.00
IUUC-Ath-006692	Arabidopsis thaliana	67.75	0.00e+00	776.00
IUUC-Ago-007900	Ashbya gossypii	27.69	3.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	33.39	4.00e-72	265.00
IUUC-Afl-008529	Aspergillus flavus	34.19	1.00e-77	283.00
IUUC-Afu-009071	Aspergillus fumigatus	32.61	9.00e-69	253.00
IUUC-Ani-009443	Aspergillus nidulans	32.36	8.00e-66	243.00
IUUC-Ang-009669	Aspergillus niger	32.49	3.00e-72	265.00
IUUC-Aor-009914	Aspergillus oryzae	33.88	2.00e-75	276.00
IUUC-Ate-010450	Aspergillus terreus	32.12	8.00e-71	260.00
IUUC-Ame-011183	Astyanax mexicanus	41.57	5.00e-127	447.00
IUUC-Bgr-012111	Blumeria graminis	32.97	3.00e-64	238.00
IUUC-Bta-012583	Bos taurus	44.59	5.00e-136	477.00
IUUC-Bci-013892	Botrytis cinerea	32.54	1.00e-61	230.00
IUUC-Bdi-014592	Brachypodium distachyon	87.33	0.00e+00	936.00
IUUC-Bol-016399	Brassica oleracea	68.26	0.00e+00	780.00
IUUC-Bra-017506	Brassica rapa	66.29	0.00e+00	756.00
IUUC-Cel-018456	Caenorhabditis elegans	31.39	7.00e-75	274.00
IUUC-Cja-020007	Callithrix jacchus	44.16	5.00e-134	470.00
IUUC-Cfa-020324	Canis familiaris	44.40	2.00e-136	478.00
IUUC-Cpo-022248	Cavia porcellus	40.17	1.00e-71	263.00
IUUC-Csa-023149	Chlorocebus sabaeus	42.03	5.00e-107	380.00
IUUC-Cho-024537	Choloepus hoffmanni	37.45	2.00e-91	328.00
IUUC-Cin-025763	Ciona intestinalis	41.68	5.00e-115	407.00
IUUC-Csv-026113	Ciona savignyi	39.34	1.00e-107	382.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.86	2.00e-59	223.00
IUUC-Cne-026884	Cryptococcus neoformans	32.39	3.00e-68	252.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.88	6.00e-15	75.10
IUUC-Dre-028140	Danio rerio	42.13	1.00e-130	459.00
IUUC-Dno-030033	Dasypus novemcinctus	44.28	2.00e-117	415.00
IUUC-Dor-030513	Dipodomys ordii	37.30	3.00e-39	155.00
IUUC-Dse-031536	Dothistroma septosporum	31.47	6.00e-67	247.00
IUUC-Dme-031683	Drosophila melanogaster	38.84	2.00e-101	362.00
IUUC-Ete-032420	Echinops telfairi	39.26	3.00e-113	401.00
IUUC-Eca-033992	Equus caballus	42.79	4.00e-106	377.00
IUUC-Eeu-034713	Erinaceus europaeus	35.10	3.00e-40	159.00
IUUC-Fca-036548	Felis catus	44.03	2.00e-135	475.00
IUUC-Fal-037600	Ficedula albicollis	43.24	5.00e-122	430.00
IUUC-Fox-038037	Fusarium oxysporum	31.44	2.00e-68	252.00
IUUC-Fso-038387	Fusarium solani	32.36	2.00e-68	252.00
IUUC-Gmo-038562	Gadus morhua	41.83	1.00e-124	439.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.23	2.00e-65	242.00
IUUC-Gga-041129	Gallus gallus	43.47	1.00e-126	446.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.87	2.00e-128	452.00
IUUC-Gma-043610	Glycine max	69.79	0.00e+00	771.00
IUUC-Ggo-045611	Gorilla gorilla	44.16	9.00e-134	469.00
IUUC-Hsa-046563	Homo sapiens	44.40	7.00e-135	473.00
IUUC-Hvu-047790	Hordeum vulgare	86.89	0.00e+00	687.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	44.59	1.00e-134	472.00
IUUC-Kpa-049309	Komagataella pastoris	35.19	1.00e-77	283.00
IUUC-Lch-050038	Latimeria chalumnae	43.45	6.00e-127	447.00
IUUC-Lpe-051535	Leersia perrieri	83.60	0.00e+00	833.00
IUUC-Loc-051917	Lepisosteus oculatus	39.31	6.00e-112	397.00
IUUC-Lma-053112	Leptosphaeria maculans	33.09	1.00e-75	276.00
IUUC-Laf-053690	Loxodonta africana	44.59	2.00e-136	478.00
IUUC-Mcc-055117	Macaca mulatta	44.07	4.00e-132	464.00
IUUC-Meu-056761	Macropus eugenii	37.26	9.00e-100	356.00
IUUC-Mor-057230	Magnaporthe oryzae	32.60	3.00e-68	252.00
IUUC-Mpo-057514	Magnaporthe poae	32.17	2.00e-63	236.00
IUUC-Mtr-058551	Medicago truncatula	67.35	0.00e+00	738.00
IUUC-Mla-059183	Melampsora laricipopulina	36.78	4.00e-92	331.00
IUUC-Mga-060144	Meleagris gallopavo	42.99	2.00e-121	428.00
IUUC-Mvi-060221	Microbotryum violaceum	32.82	5.00e-77	281.00
IUUC-Mmr-061325	Microcebus murinus	43.41	2.00e-131	461.00
IUUC-Mdo-062532	Monodelphis domestica	45.08	6.00e-135	473.00
IUUC-Mmu-063956	Mus musculus	44.03	1.00e-134	472.00
IUUC-Mac-064521	Musa acuminata	73.62	0.00e+00	833.00
IUUC-Mpu-066716	Mustela putorius furo	44.64	1.00e-126	446.00
IUUC-Mlu-067459	Myotis lucifugus	45.28	8.00e-137	479.00
IUUC-Nfi-068245	Neosartorya fischeri	32.91	1.00e-69	256.00
IUUC-Ncr-068910	Neurospora crassa	32.84	5.00e-68	251.00
IUUC-Nle-070034	Nomascus leucogenys	43.44	3.00e-127	448.00
IUUC-Opr-070552	Ochotona princeps	40.24	2.00e-102	365.00
IUUC-Ont-071426	Oreochromis niloticus	42.40	2.00e-130	458.00
IUUC-Oan-073389	Ornithorhynchus anatinus	40.54	3.00e-93	334.00
IUUC-Ocu-074911	Oryctolagus cuniculus	44.86	2.00e-136	478.00
IUUC-Oba-075437	Oryza barthii	88.48	0.00e+00	905.00
IUUC-Obr-076684	Oryza brachyantha	86.51	0.00e+00	845.00
IUUC-Ogl-077170	Oryza glaberrima	88.48	0.00e+00	905.00
IUUC-Ogu-078844	Oryza glumaepatula	87.73	0.00e+00	857.00
IUUC-Oin-079105	Oryza indica	88.48	0.00e+00	904.00
IUUC-Olo-080943	Oryza longistaminata	85.63	0.00e+00	829.00
IUUC-Oni-082891	Oryza nivara	85.80	0.00e+00	874.00
IUUC-Opu-083457	Oryza punctata	88.48	0.00e+00	904.00
IUUC-Oru-084960	Oryza rufipogon	85.26	0.00e+00	832.00
IUUC-Osa-085358	Oryza sativa	88.29	0.00e+00	899.00
IUUC-Ola-086420	Oryzias latipes	40.16	7.00e-82	296.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.66	2.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	44.78	5.00e-136	477.00
IUUC-Oar-089196	Ovis aries	44.53	1.00e-134	472.00
IUUC-Ptr-090617	Pan troglodytes	44.40	5.00e-135	473.00
IUUC-Pan-092761	Papio anubis	44.59	4.00e-136	477.00
IUUC-Psi-093191	Pelodiscus sinensis	41.70	7.00e-126	443.00
IUUC-Pma-094380	Petromyzon marinus	41.94	1.00e-114	405.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.92	3.00e-63	236.00
IUUC-Ppa-095798	Physcomitrella patens	55.26	2.00e-180	624.00
IUUC-Pfo-096467	Poecilia formosa	41.42	8.00e-125	439.00
IUUC-Pab-098255	Pongo abelii	45.39	4.00e-112	397.00
IUUC-Pop-099722	Populus trichocarpa	70.94	0.00e+00	808.00
IUUC-Pca-100807	Procavia capensis	52.41	7.00e-55	207.00
IUUC-Ppe-101280	Prunus persica	69.22	0.00e+00	793.00
IUUC-Pva-102333	Pteropus vampyrus	43.04	7.00e-128	449.00
IUUC-Pgr-103401	Puccinia graminis	30.76	2.00e-73	269.00
IUUC-Ptt-103889	Puccinia triticina	29.38	2.00e-63	236.00
IUUC-Pte-104355	Pyrenophora teres	32.79	4.00e-70	258.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.43	8.00e-70	257.00
IUUC-Rno-105810	Rattus norvegicus	43.66	7.00e-133	466.00
IUUC-Sce-106397	Saccharomyces cerevisiae	28.92	1.00e-34	140.00
IUUC-Sha-106770	Sarcophilus harrisii	50.00	2.00e-73	268.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	34.94	1.00e-83	302.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.91	7.00e-83	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.21	5.00e-61	228.00
IUUC-Smo-109296	Selaginella moellendorffii	54.13	1.00e-167	582.00
IUUC-Sly-111105	Solanum lycopersicum	67.41	0.00e+00	777.00
IUUC-Stu-112469	Solanum tuberosum	68.16	0.00e+00	786.00
IUUC-Sar-113083	Sorex araneus	35.40	7.00e-91	327.00
IUUC-Sbi-113813	Sorghum bicolor	92.25	0.00e+00	1024.00
IUUC-Sre-115058	Sporisorium reilianum	34.99	8.00e-68	250.00
IUUC-Tgu-116772	Taeniopygia guttata	43.83	3.00e-122	431.00
IUUC-Tru-118686	Takifugu rubripes	41.90	4.00e-129	454.00
IUUC-Tsy-119111	Tarsius syrichta	45.09	2.00e-64	239.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.96	2.00e-113	402.00
IUUC-Tca-121491	Theobroma cacao	70.36	0.00e+00	764.00
IUUC-Tre-122103	Trichoderma reesei	33.21	1.00e-76	280.00
IUUC-Tvi-122672	Trichoderma virens	32.71	7.00e-71	260.00
IUUC-Tae-125316	Triticum aestivum	88.29	0.00e+00	945.00
IUUC-Tur-126487	Triticum urartu	86.85	0.00e+00	915.00
IUUC-Tme-127097	Tuber melanosporum	35.54	2.00e-82	299.00
IUUC-Ttr-128465	Tursiops truncatus	41.37	1.00e-119	422.00
IUUC-Uma-129645	Ustilago maydis	33.48	1.00e-65	243.00
IUUC-Vda-129989	Verticillium dahliae	29.50	5.00e-52	197.00
IUUC-Vpa-130529	Vicugna pacos	42.12	6.00e-124	437.00
IUUC-Vvi-131059	Vitis vinifera	71.89	0.00e+00	799.00
IUUC-Xtr-132002	Xenopus tropicalis	44.03	2.00e-132	465.00
IUUC-Xma-133930	Xiphophorus maculatus	41.73	1.00e-128	452.00
IUUC-Yli-134505	Yarrowia lipolytica	33.53	1.00e-79	289.00
IUUC-Zma-135619	Zea mays	91.30	0.00e+00	969.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence