iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008602

Ensembl Protein ID

EED47094

UniProt Accession

B8NSV5; CREB_ASPFN

Genbank Protein ID

EED47094.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

EQ963483

Gene Name

creB; AFLA_051480

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_051480	EED47094	EED47094

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.10e-96	320.7	55	467

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
419	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp........................................................... 42
           +G++N gNtCY+NS+LQcL+   ++re++ + ++ +++ e+                                                            
   Q: 55   FGMENYGNTCYCNSILQCLYYSVPFREAVVN-YPTRTPIESLeaalantlryqnfaanleaealaekqkaanaqrpgappnqpqkpedkdspeykkkmalq 154
           69*****************************.55555554445666777777788888888899999999999999***********99999999999999 PP
   S: 43   .............kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsd 128
                         +++++l +sl++lfe+++  +s+ + + p+++l++l++e+e+f++ ++qDa+Efl+ ll+++  +++ e++k+ e e++    e+ d
   Q: 155  tlplletknnatsYGMSESLFTSLKDLFESVVasQSRIGIIRPQHFLDVLRREHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPEPERSLPPAESAD 255
           999999999999989999*************98899999*****************************************885555555555544444444 PP
   S: 129  e.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklk 224
           +     ++ +k+  ++ ++++lF+g+l+s+++cl+c++vs+r+e fldls+++++++     s+++cL++f++ee+l+++nk++c++c ++qeaek++k+k
   Q: 256  StelsgSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEVFLDLSVDLEQHS-----SVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIK 351
           45567777788888889****************************************.....9************************************** PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevle 324
           +lP++L lhLkRf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++ +GHYva++k ++++WllfdD+ V++v+++ v +
   Q: 352  RLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGPYHGHYVAIIKTQDRGWLLFDDEMVEPVDKNYVRN 449
           ********************************88887..566645544.49************************************************** PP
   S: 325  etg.....staYvlfYkr 337
           + g     + aYvlfY++
   Q: 450  FFGdrpglACAYVLFYQE 467
           999*************97 PP

Organism

Aspergillus flavus

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).

Protein Sequence
(Fasta)

MGSFLRSLRR DVGPPTPSVG ATPAKKEPPV PPVTPLEKML QDMGAIREDG SDKFFGMENY 60
GNTCYCNSIL QCLYYSVPFR EAVVNYPTRT PIESLEAALA NTLRYQNFAA NLEAEALAEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCGT TTCTAAGGAG TCTACGCAGA GATGTGGTGA GTGGTTCTGT CCTCGTTTTG 60
CCTTCCGGTC TTTTGTCTCG TTTCGCCATC GTGATAGGGT CTCTTTTCCA GGGTGTGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afv:AFLA_051480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	46.79	4.00e-83	299.00
IUUC-Aml-001964	Ailuropoda melanoleuca	50.84	5.00e-87	312.00
IUUC-Atr-002650	Amborella trichopoda	47.90	3.00e-83	300.00
IUUC-Apl-003733	Anas platyrhynchos	49.16	6.00e-83	298.00
IUUC-Aca-005212	Anolis carolinensis	51.84	1.00e-86	311.00
IUUC-Aly-005830	Arabidopsis lyrata	47.70	7.00e-78	281.00
IUUC-Ath-006663	Arabidopsis thaliana	47.67	3.00e-81	293.00
IUUC-Ago-007871	Ashbya gossypii	41.34	2.00e-64	238.00
IUUC-Acl-008239	Aspergillus clavatus	85.50	0.00e+00	875.00
IUUC-Afu-008816	Aspergillus fumigatus	85.50	0.00e+00	890.00
IUUC-Ani-009137	Aspergillus nidulans	70.01	0.00e+00	850.00
IUUC-Ang-009703	Aspergillus niger	72.63	0.00e+00	900.00
IUUC-Aor-009901	Aspergillus oryzae	96.88	0.00e+00	1168.00
IUUC-Ate-010431	Aspergillus terreus	76.04	0.00e+00	943.00
IUUC-Ame-011015	Astyanax mexicanus	51.84	3.00e-87	313.00
IUUC-Bgr-012071	Blumeria graminis	56.67	8.00e-159	551.00
IUUC-Bta-012981	Bos taurus	51.51	3.00e-87	313.00
IUUC-Bci-013837	Botrytis cinerea	56.25	1.00e-173	601.00
IUUC-Bdi-014008	Brachypodium distachyon	46.43	7.00e-82	295.00
IUUC-Bol-015409	Brassica oleracea	48.51	3.00e-81	294.00
IUUC-Bra-016956	Brassica rapa	48.51	5.00e-82	296.00
IUUC-Cel-018379	Caenorhabditis elegans	42.01	3.00e-74	270.00
IUUC-Cja-018831	Callithrix jacchus	51.17	2.00e-87	314.00
IUUC-Cfa-020534	Canis familiaris	50.50	1.00e-86	311.00
IUUC-Cpo-021703	Cavia porcellus	50.84	4.00e-87	312.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	47.04	1.00e-65	241.00
IUUC-Csa-023841	Chlorocebus sabaeus	47.83	7.00e-81	291.00
IUUC-Cho-024902	Choloepus hoffmanni	40.13	4.00e-59	219.00
IUUC-Cin-025659	Ciona intestinalis	39.33	5.00e-71	259.00
IUUC-Csv-025828	Ciona savignyi	38.69	4.00e-71	259.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	56.46	3.00e-173	599.00
IUUC-Cne-026900	Cryptococcus neoformans	39.33	2.00e-67	248.00
IUUC-Cme-027339	Cyanidioschyzon merolae	32.86	3.00e-37	147.00
IUUC-Dre-027845	Danio rerio	51.84	9.00e-88	315.00
IUUC-Dno-029460	Dasypus novemcinctus	50.50	3.00e-86	310.00
IUUC-Dor-030972	Dipodomys ordii	52.11	1.00e-76	278.00
IUUC-Dse-031470	Dothistroma septosporum	52.48	1.00e-174	604.00
IUUC-Dme-032038	Drosophila melanogaster	56.57	6.00e-68	249.00
IUUC-Ete-032659	Echinops telfairi	54.24	1.00e-54	204.00
IUUC-Eca-033439	Equus caballus	50.84	4.00e-87	312.00
IUUC-Eeu-034916	Erinaceus europaeus	51.45	3.00e-66	243.00
IUUC-Fca-035524	Felis catus	50.84	1.00e-86	311.00
IUUC-Fal-036833	Ficedula albicollis	51.51	2.00e-86	310.00
IUUC-Fox-037682	Fusarium oxysporum	60.00	3.00e-166	577.00
IUUC-Fso-038299	Fusarium solani	58.10	3.00e-158	550.00
IUUC-Gmo-038763	Gadus morhua	51.84	9.00e-87	311.00
IUUC-Ggr-039806	Gaeumannomyces graminis	58.13	7.00e-175	605.00
IUUC-Gga-041151	Gallus gallus	50.17	8.00e-86	308.00
IUUC-Gac-041967	Gasterosteus aculeatus	51.17	5.00e-86	309.00
IUUC-Gma-043101	Glycine max	48.22	4.00e-85	306.00
IUUC-Ggo-044659	Gorilla gorilla	49.16	1.00e-80	291.00
IUUC-Hsa-045700	Homo sapiens	51.17	2.00e-87	314.00
IUUC-Hvu-047692	Hordeum vulgare	47.25	5.00e-81	292.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	50.84	3.00e-87	313.00
IUUC-Kpa-049250	Komagataella pastoris	50.16	1.00e-93	335.00
IUUC-Lch-050435	Latimeria chalumnae	51.17	7.00e-86	308.00
IUUC-Lpe-051368	Leersia perrieri	45.45	1.00e-79	288.00
IUUC-Loc-051968	Lepisosteus oculatus	50.84	2.00e-85	307.00
IUUC-Lma-053300	Leptosphaeria maculans	58.97	0.00e+00	642.00
IUUC-Laf-053887	Loxodonta africana	50.84	4.00e-87	312.00
IUUC-Mcc-055701	Macaca mulatta	51.17	2.00e-87	314.00
IUUC-Mor-057072	Magnaporthe oryzae	61.72	7.00e-173	598.00
IUUC-Mpo-057424	Magnaporthe poae	57.76	1.00e-173	601.00
IUUC-Mtr-057715	Medicago truncatula	48.25	1.00e-83	300.00
IUUC-Mla-059142	Melampsora laricipopulina	54.85	4.00e-101	361.00
IUUC-Mga-059195	Meleagris gallopavo	50.17	1.00e-85	308.00
IUUC-Mvi-060357	Microbotryum violaceum	55.56	1.00e-85	309.00
IUUC-Mmr-060751	Microcebus murinus	50.84	4.00e-87	312.00
IUUC-Mdo-062735	Monodelphis domestica	50.84	5.00e-87	312.00
IUUC-Mmu-063263	Mus musculus	50.50	7.00e-86	308.00
IUUC-Mac-065323	Musa acuminata	47.73	2.00e-78	283.00
IUUC-Mpu-066038	Mustela putorius furo	49.16	6.00e-81	292.00
IUUC-Mlu-068128	Myotis lucifugus	50.84	4.00e-87	312.00
IUUC-Nfi-068611	Neosartorya fischeri	75.61	0.00e+00	907.00
IUUC-Ncr-068699	Neurospora crassa	60.58	1.00e-174	605.00
IUUC-Nle-069767	Nomascus leucogenys	51.17	1.00e-87	314.00
IUUC-Opr-070980	Ochotona princeps	49.16	1.00e-80	291.00
IUUC-Ont-072658	Oreochromis niloticus	51.17	5.00e-86	309.00
IUUC-Oan-073372	Ornithorhynchus anatinus	50.84	1.00e-85	308.00
IUUC-Ocu-074322	Oryctolagus cuniculus	51.17	6.00e-87	312.00
IUUC-Oba-075220	Oryza barthii	45.34	5.00e-80	289.00
IUUC-Obr-076208	Oryza brachyantha	47.08	1.00e-75	274.00
IUUC-Ogl-077216	Oryza glaberrima	45.34	5.00e-80	289.00
IUUC-Ogu-078836	Oryza glumaepatula	45.34	5.00e-80	289.00
IUUC-Oin-079522	Oryza indica	45.34	5.00e-80	289.00
IUUC-Olo-080882	Oryza longistaminata	45.34	5.00e-80	289.00
IUUC-Ome-081549	Oryza meridionalis	45.34	5.00e-80	289.00
IUUC-Oni-082982	Oryza nivara	45.34	5.00e-80	289.00
IUUC-Opu-083532	Oryza punctata	46.30	3.00e-80	290.00
IUUC-Oru-084568	Oryza rufipogon	45.34	5.00e-80	289.00
IUUC-Osa-085299	Oryza sativa	45.34	5.00e-80	289.00
IUUC-Ola-087418	Oryzias latipes	51.17	3.00e-86	310.00
IUUC-Olu-087809	Ostreococcus lucimarinus	43.48	3.00e-64	236.00
IUUC-Oga-088298	Otolemur garnettii	50.84	8.00e-87	311.00
IUUC-Oar-090269	Ovis aries	51.51	1.00e-86	311.00
IUUC-Ptr-090467	Pan troglodytes	51.17	2.00e-87	314.00
IUUC-Pan-092437	Papio anubis	51.00	3.00e-86	310.00
IUUC-Psi-092993	Pelodiscus sinensis	50.50	9.00e-87	311.00
IUUC-Pma-094388	Petromyzon marinus	49.83	7.00e-84	301.00
IUUC-Pno-095044	Phaeosphaeria nodorum	59.00	1.00e-177	615.00
IUUC-Ppa-095275	Physcomitrella patens	49.17	1.00e-85	307.00
IUUC-Pfo-097052	Poecilia formosa	51.17	4.00e-86	309.00
IUUC-Pab-097797	Pongo abelii	51.17	2.00e-87	314.00
IUUC-Pop-099016	Populus trichocarpa	50.00	1.00e-85	308.00
IUUC-Pca-100835	Procavia capensis	53.53	6.00e-71	258.00
IUUC-Ppe-101474	Prunus persica	48.25	3.00e-84	303.00
IUUC-Pva-102878	Pteropus vampyrus	51.53	5.00e-87	312.00
IUUC-Pgr-103306	Puccinia graminis	55.37	3.00e-104	371.00
IUUC-Ptt-103887	Puccinia triticina	31.88	2.00e-28	118.00
IUUC-Pte-104356	Pyrenophora teres	57.08	0.00e+00	642.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	54.39	1.00e-163	567.00
IUUC-Rno-106060	Rattus norvegicus	50.84	2.00e-86	310.00
IUUC-Sce-106367	Saccharomyces cerevisiae	41.94	2.00e-73	268.00
IUUC-Sha-107087	Sarcophilus harrisii	50.84	4.00e-87	312.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	42.07	3.00e-96	343.00
IUUC-Spo-108095	Schizosaccharomyces pombe	43.10	5.00e-108	383.00
IUUC-Smo-108674	Selaginella moellendorffii	51.17	3.00e-87	313.00
IUUC-Sit-110819	Setaria italica	46.25	1.00e-81	294.00
IUUC-Sly-111210	Solanum lycopersicum	48.87	7.00e-84	301.00
IUUC-Stu-112398	Solanum tuberosum	48.16	4.00e-80	289.00
IUUC-Sar-113216	Sorex araneus	50.50	2.00e-85	306.00
IUUC-Sbi-114724	Sorghum bicolor	47.73	2.00e-84	303.00
IUUC-Sre-115197	Sporisorium reilianum	56.79	8.00e-93	333.00
IUUC-Ssc-116321	Sus scrofa	51.17	3.00e-87	313.00
IUUC-Tgu-117482	Taeniopygia guttata	50.84	4.00e-85	306.00
IUUC-Tru-118613	Takifugu rubripes	51.17	3.00e-86	309.00
IUUC-Tsy-119520	Tarsius syrichta	54.68	5.00e-61	225.00
IUUC-Tni-120293	Tetraodon nigroviridis	51.17	3.00e-86	309.00
IUUC-Tca-121329	Theobroma cacao	49.00	1.00e-83	301.00
IUUC-Tre-122226	Trichoderma reesei	52.44	1.00e-164	571.00
IUUC-Tvi-122330	Trichoderma virens	52.62	9.00e-162	561.00
IUUC-Tae-124807	Triticum aestivum	47.25	3.00e-84	303.00
IUUC-Tur-126563	Triticum urartu	47.25	2.00e-84	303.00
IUUC-Tme-126890	Tuber melanosporum	66.67	2.00e-136	477.00
IUUC-Tbe-127783	Tupaia belangeri	50.84	4.00e-87	312.00
IUUC-Ttr-129083	Tursiops truncatus	51.17	1.00e-87	314.00
IUUC-Uma-129409	Ustilago maydis	55.09	9.00e-93	333.00
IUUC-Vda-129736	Verticillium dahliae	44.91	8.00e-148	515.00
IUUC-Vpa-130391	Vicugna pacos	47.51	2.00e-77	280.00
IUUC-Vvi-131371	Vitis vinifera	49.19	2.00e-86	310.00
IUUC-Xtr-132464	Xenopus tropicalis	50.67	7.00e-85	305.00
IUUC-Xma-133475	Xiphophorus maculatus	51.17	4.00e-86	309.00
IUUC-Yli-134632	Yarrowia lipolytica	59.78	7.00e-126	442.00
IUUC-Zma-134951	Zea mays	46.75	3.00e-82	296.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence