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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032111
UUCD1 version UUC-DrM-00641
Ensembl Protein ID FBpp0087735
UniProt Accession A1Z7K9; A1Z7K9_DROME
Genbank Protein ID AAF59018.2; ABX00764.1
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID AE013599; BT031142
Gene Name PAN2; CG8232; Dmel_CG8232
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0033352 FBtr0088654 FBpp0087735
FBgn0033352 FBtr0339303 FBpp0308411
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.70e-13 50.5 514 965
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 10   CYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefs...........gyeqqDaqEf 95
            Y+N++LQ L+++  lr  lle   +++ +      + +l+++l  lf+ l  ++ ++  + +++l++++++ e               +     q  
   Q: 514  SYCNAMLQILYFTDALRVKLLE---HSCIK------EFCLSCELGFLFNMLDkSTASSPCQASNFLRSFRTVPEASAlgliltdrssnVNLISLIQNW 602
           6*********************...77765......57**********9998788889999999*****99998866778876554444444457999 PP
   S: 96   laflldqleeelkk............eknkpkeeeeeedkselsde.........................aeekkkkknkslisdlFqgqlksqikc 156
            +f+l+q++ e+              +++++              e                          +e+ k   ++ is++F+ +     +c
   Q: 603  NRFILHQMHYEIFDssknastysgsvQTSTNA-------------EnagssetsgssdlydsisdenskedDRERSKINAETDISKIFGTKQICINRC 687
           9**********944333344444332222222.............12345555666677999999887765444555555699********999999* PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke..slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf.....sfseeqksre 247
            +c++++ +e+  l  +l+ p++ + + +  ++  +L+   + e+     + +ce+ckk + +++++k+++lP++L+++         +f ++q +r 
   Q: 688  IKCQEEKIKESILLACNLSYPNHIKDSDQyfNFGTILKRSLSSEKSI---QAFCERCKKFSPTNQSVKVTSLPQILSINCGLNnekdiTFLKRQLNRC 782
           *******99999988888888776655444499999*7776666654...38**************************98655223336666666665 PP
   S: 248  kinkkvefpleLdlspfcts............................................................................pe 269
             ++ v+   +L+ s+ c                                                                              p 
   Q: 783  SEKTTVDAAASLSTSKPCRYgancsrsdchfmhpdrkspshtsqpnavnnspngrqkswfpltftmgindqgevqvqtqsdassgkseqeeetekpP- 879
           6666666666666666555588899999999999999998888888888888888888888888888887777777777777766665555555554. PP
   S: 270  ekqke.....kkkYeLiavvvHsGslssGHYvayvkn...............ekgkWllfdDskVtevkeeevleetg..staYvlfYkr 337
               +     ++ Y L+avv+      +   v++++                 + +W+ f+D ++++v+ +e + +t   + + +lfY++
   Q: 880  ----TkgldnNRMYALHAVVCQVDDGTQKNLVSLINVqrpyhtmklaesaddPQSQWYIFNDFSISPVSPQESVWFTLdwKVPCILFYRH 965
           ....055555*************977777899999998888888888877776888*************999888887889999999987 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MDYVYCGTDP IGASEDILSV YDAGSAPGNG HFSPSFNGFN IGTTDPEYVE LVPVLADGGE 60
HFGVSSVAFD DYEELLWMGN QGGHVTSYYT NSMQKYTSFQ VHATDIVRDI STLDSGVLAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032111|DUB,USP|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGAGTAT TTTTACATCA GCCCTGCCAG GGTCACTCTA ATCGGTGCAA CGCAAAAACG 60
GCTGGCAGTT TTGAGCGAAA TTTGTTAAAA AATAAACAAT AAAAAGTCGC GTGGGCATCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032111|DUB,USP|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 41.43 0.00e+00 880.00
IUUC-Apl-003500 Anas platyrhynchos 43.68 4.00e-135 475.00
IUUC-Aca-004930 Anolis carolinensis 43.00 0.00e+00 905.00
IUUC-Acl-008214 Aspergillus clavatus 28.70 2.00e-76 280.00
IUUC-Afu-009112 Aspergillus fumigatus 28.24 1.00e-69 258.00
IUUC-Ang-009531 Aspergillus niger 29.55 1.00e-75 277.00
IUUC-Ame-011259 Astyanax mexicanus 44.89 1.00e-138 486.00
IUUC-Bta-012371 Bos taurus 39.98 0.00e+00 878.00
IUUC-Bci-013684 Botrytis cinerea 39.17 1.00e-63 237.00
IUUC-Cja-019297 Callithrix jacchus 40.50 0.00e+00 857.00
IUUC-Cfa-020489 Canis familiaris 41.25 0.00e+00 872.00
IUUC-Cpo-022392 Cavia porcellus 41.63 0.00e+00 889.00
IUUC-Csa-023220 Chlorocebus sabaeus 41.09 0.00e+00 882.00
IUUC-Csv-025841 Ciona savignyi 39.87 0.00e+00 744.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 28.19 1.00e-76 281.00
IUUC-Cne-026932 Cryptococcus neoformans 39.94 2.00e-69 256.00
IUUC-Dre-028482 Danio rerio 40.71 0.00e+00 854.00
IUUC-Dno-029398 Dasypus novemcinctus 41.56 0.00e+00 880.00
IUUC-Dor-030307 Dipodomys ordii 62.22 6.00e-80 291.00
IUUC-Eca-033985 Equus caballus 41.28 0.00e+00 878.00
IUUC-Eeu-034928 Erinaceus europaeus 41.51 4.00e-79 289.00
IUUC-Fca-035587 Felis catus 41.48 0.00e+00 885.00
IUUC-Fal-037587 Ficedula albicollis 45.33 4.00e-140 492.00
IUUC-Fso-038133 Fusarium solani 39.56 4.00e-68 252.00
IUUC-Gmo-039076 Gadus morhua 44.23 2.00e-134 473.00
IUUC-Ggr-039957 Gaeumannomyces graminis 27.18 3.00e-69 256.00
IUUC-Gga-040948 Gallus gallus 42.13 0.00e+00 879.00
IUUC-Gac-042396 Gasterosteus aculeatus 42.62 6.00e-136 478.00
IUUC-Ggo-045412 Gorilla gorilla 41.30 0.00e+00 879.00
IUUC-Hsa-046076 Homo sapiens 41.17 0.00e+00 882.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 38.89 0.00e+00 788.00
IUUC-Kpa-049178 Komagataella pastoris 36.44 1.00e-59 224.00
IUUC-Lch-050279 Latimeria chalumnae 42.11 3.00e-117 416.00
IUUC-Loc-052872 Lepisosteus oculatus 40.59 0.00e+00 860.00
IUUC-Lma-052986 Leptosphaeria maculans 28.13 7.00e-78 285.00
IUUC-Laf-054181 Loxodonta africana 40.94 0.00e+00 847.00
IUUC-Mcc-054812 Macaca mulatta 41.26 0.00e+00 880.00
IUUC-Meu-056325 Macropus eugenii 42.32 0.00e+00 884.00
IUUC-Mor-057246 Magnaporthe oryzae 26.56 1.00e-58 221.00
IUUC-Mpo-057464 Magnaporthe poae 27.54 2.00e-68 253.00
IUUC-Mla-058911 Melampsora laricipopulina 37.02 1.00e-63 238.00
IUUC-Mga-059335 Meleagris gallopavo 42.39 0.00e+00 849.00
IUUC-Mvi-060461 Microbotryum violaceum 29.65 2.00e-130 459.00
IUUC-Mmr-060636 Microcebus murinus 41.20 0.00e+00 876.00
IUUC-Mmu-063503 Mus musculus 41.86 0.00e+00 884.00
IUUC-Mpu-066670 Mustela putorius furo 41.55 0.00e+00 881.00
IUUC-Mlu-068119 Myotis lucifugus 40.90 0.00e+00 884.00
IUUC-Nfi-068398 Neosartorya fischeri 29.65 2.00e-78 287.00
IUUC-Ncr-068927 Neurospora crassa 28.20 2.00e-114 406.00
IUUC-Nle-069651 Nomascus leucogenys 40.17 0.00e+00 840.00
IUUC-Opr-070614 Ochotona princeps 41.57 0.00e+00 882.00
IUUC-Ont-072433 Oreochromis niloticus 43.56 6.00e-140 491.00
IUUC-Oan-073283 Ornithorhynchus anatinus 39.09 0.00e+00 664.00
IUUC-Ocu-074401 Oryctolagus cuniculus 41.20 0.00e+00 882.00
IUUC-Ola-087522 Oryzias latipes 40.60 0.00e+00 866.00
IUUC-Oga-088226 Otolemur garnettii 41.05 0.00e+00 878.00
IUUC-Oar-089241 Ovis aries 40.88 0.00e+00 880.00
IUUC-Pan-092297 Papio anubis 41.08 0.00e+00 817.00
IUUC-Psi-094043 Pelodiscus sinensis 45.20 4.00e-137 481.00
IUUC-Pma-094394 Petromyzon marinus 39.85 0.00e+00 824.00
IUUC-Pno-095053 Phaeosphaeria nodorum 28.26 4.00e-66 245.00
IUUC-Ppa-095188 Physcomitrella patens 41.85 4.00e-67 249.00
IUUC-Pfo-097517 Poecilia formosa 43.51 2.00e-138 486.00
IUUC-Pca-100471 Procavia capensis 40.79 0.00e+00 858.00
IUUC-Pva-102805 Pteropus vampyrus 39.38 0.00e+00 704.00
IUUC-Pte-104021 Pyrenophora teres 28.65 2.00e-80 293.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 28.11 2.00e-78 287.00
IUUC-Rno-105471 Rattus norvegicus 41.80 0.00e+00 887.00
IUUC-Sce-106235 Saccharomyces cerevisiae 37.29 2.00e-58 220.00
IUUC-Sha-106883 Sarcophilus harrisii 41.98 0.00e+00 857.00
IUUC-Spo-108169 Schizosaccharomyces pombe 39.83 1.00e-71 264.00
IUUC-Sar-113323 Sorex araneus 41.20 0.00e+00 676.00
IUUC-Sre-115075 Sporisorium reilianum 45.75 4.00e-54 206.00
IUUC-Ssc-116363 Sus scrofa 41.45 0.00e+00 884.00
IUUC-Tru-118427 Takifugu rubripes 40.31 0.00e+00 872.00
IUUC-Tni-120218 Tetraodon nigroviridis 40.57 0.00e+00 876.00
IUUC-Tre-122177 Trichoderma reesei 27.11 2.00e-67 250.00
IUUC-Tme-127176 Tuber melanosporum 37.50 9.00e-64 238.00
IUUC-Tbe-127641 Tupaia belangeri 37.76 2.00e-68 253.00
IUUC-Ttr-128888 Tursiops truncatus 41.58 6.00e-164 571.00
IUUC-Uma-129361 Ustilago maydis 45.53 3.00e-56 213.00
IUUC-Xtr-132811 Xenopus tropicalis 43.69 5.00e-134 471.00
Created Date 25-Jun-2017

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