iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000010234.7	ENSRNOT00000089666.1	ENSRNOP00000073042.1
ENSRNOG00000010234.7	ENSRNOT00000014289.6	ENSRNOP00000014289.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-22	77.8	715	743
UBD/Beta-Prp	3.10e-52	178.0	683	918

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWD 29
           gH d v+ +++ + ++l s+s+D t+kvW+
   Q: 715  GHDDAVSKICWhN-DRLYSASWDSTVKVWS 743
           8**********55.899************7 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls.......tgkcvhtlkghed 95
              p+++ ++++s+d+ +  +++  g    +l gh+++v+ +++++d   l ++s D t+kvw   + +       +++ +  l+ h+ 
   Q: 683  L-LPGDTTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSASWDSTVKVWsgvPAEmpgtkrhQFDLLAELE-HDV 767
           3.48999****************************************..7*************8773336666666888888888.*** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           sv ++++++ +  lvsG++   +++wdl t + l+   s h+g+v+ ++++pd++ + s + D+++++ d++tg l+  + +  +++ +
   Q: 768  SVNTINLNAVSTLLVSGTKEGLVNIWDLTTATLLH-QISCHSGTVCDAAFSPDSRHVLSTGVDGCLNVIDVQTGMLISSMAS--EEPQR 853
           ***********************************.99******************************************65..9999* PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           +  +d n  +++sgs+ g + +wdl   ++ ++ +ght  v+++ + ++   +++g++D+++ +W l
   Q: 854  CFVWDGN--SVLSGSRTGELLVWDLLGAKVSERIQGHTGAVTCIWMNEQCSSIITGGEDRQVMFWKL 918
           ******6..6*******************************************************76 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAFTRKRQRE QQLQLYSKER FSLLLLNLEE YYFEQHTAFH VQHQGSPEER KIRGSLKICS 60
KSVIFEPDAI SQPILKIPLR DCLKIGKHGE NGANKHFAKA KSLGISLIFS QVYFIKEHNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACGGCGTC GCCGGAGTCC CCACGCGAGG ATGCTGCGGT GAGCGAGGTC CGGACGCCGC 60
GGGCCCTGGG GCGCAGCGTG GGGCTCTCGG CCGCCCGCCC AGCGCCGCCG CTCGGGACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR000409--BEACH_dom
IPR004182--GRAM
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF02893--GRAM
PF00400--WD40

SMART

SM01026--Beach
SM00568--GRAM
SM00320--WD40

Gene Ontology

GO:0016230--F:sphingomyelin phosphodiesterase activator activity
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001408	Ailuropoda melanoleuca	90.61	0.00e+00	1718.00
IUUC-Apl-004000	Anas platyrhynchos	78.74	0.00e+00	1504.00
IUUC-Aca-005253	Anolis carolinensis	76.83	0.00e+00	1459.00
IUUC-Ame-011654	Astyanax mexicanus	70.75	0.00e+00	1291.00
IUUC-Bta-013201	Bos taurus	86.42	0.00e+00	1647.00
IUUC-Cja-019039	Callithrix jacchus	91.67	0.00e+00	1722.00
IUUC-Cfa-020722	Canis familiaris	91.03	0.00e+00	1719.00
IUUC-Cpo-022247	Cavia porcellus	89.38	0.00e+00	1681.00
IUUC-Csa-023753	Chlorocebus sabaeus	92.38	0.00e+00	1744.00
IUUC-Cho-024757	Choloepus hoffmanni	89.65	0.00e+00	1376.00
IUUC-Dre-027693	Danio rerio	70.03	0.00e+00	1270.00
IUUC-Dno-028878	Dasypus novemcinctus	91.14	0.00e+00	1696.00
IUUC-Dor-030632	Dipodomys ordii	80.54	0.00e+00	1479.00
IUUC-Ete-032305	Echinops telfairi	82.31	0.00e+00	972.00
IUUC-Eca-034177	Equus caballus	92.79	0.00e+00	1753.00
IUUC-Eeu-034512	Erinaceus europaeus	72.93	0.00e+00	1172.00
IUUC-Fca-036028	Felis catus	89.28	0.00e+00	1694.00
IUUC-Fal-036685	Ficedula albicollis	78.07	0.00e+00	1441.00
IUUC-Gmo-038959	Gadus morhua	69.69	0.00e+00	1159.00
IUUC-Gga-040819	Gallus gallus	76.96	0.00e+00	1468.00
IUUC-Gac-041843	Gasterosteus aculeatus	68.61	0.00e+00	1293.00
IUUC-Ggo-045488	Gorilla gorilla	84.94	0.00e+00	1597.00
IUUC-Hsa-046714	Homo sapiens	92.44	0.00e+00	1742.00
IUUC-Itr-048950	Ictidomys tridecemlineatus	93.88	0.00e+00	1437.00
IUUC-Lch-050024	Latimeria chalumnae	63.07	0.00e+00	1117.00
IUUC-Loc-052831	Lepisosteus oculatus	73.83	0.00e+00	1400.00
IUUC-Laf-053693	Loxodonta africana	90.01	0.00e+00	1677.00
IUUC-Mcc-054769	Macaca mulatta	90.81	0.00e+00	1709.00
IUUC-Mga-059891	Meleagris gallopavo	77.14	0.00e+00	1427.00
IUUC-Mmr-060948	Microcebus murinus	91.96	0.00e+00	1753.00
IUUC-Mdo-062721	Monodelphis domestica	84.69	0.00e+00	1588.00
IUUC-Mmu-064167	Mus musculus	96.96	0.00e+00	1867.00
IUUC-Mpu-066243	Mustela putorius furo	90.76	0.00e+00	1751.00
IUUC-Mlu-068009	Myotis lucifugus	89.39	0.00e+00	1663.00
IUUC-Nle-069459	Nomascus leucogenys	91.89	0.00e+00	1728.00
IUUC-Opr-071145	Ochotona princeps	80.45	0.00e+00	1338.00
IUUC-Ont-071781	Oreochromis niloticus	68.30	0.00e+00	1311.00
IUUC-Oan-073456	Ornithorhynchus anatinus	83.12	0.00e+00	1558.00
IUUC-Ocu-073989	Oryctolagus cuniculus	91.96	0.00e+00	1775.00
IUUC-Ola-087535	Oryzias latipes	66.31	0.00e+00	1264.00
IUUC-Oga-089183	Otolemur garnettii	87.78	0.00e+00	1608.00
IUUC-Oar-090420	Ovis aries	87.15	0.00e+00	1637.00
IUUC-Ptr-091559	Pan troglodytes	92.28	0.00e+00	1779.00
IUUC-Pan-092213	Papio anubis	92.25	0.00e+00	1750.00
IUUC-Psi-093142	Pelodiscus sinensis	81.09	0.00e+00	1501.00
IUUC-Ppa-095631	Physcomitrella patens	40.20	5.00e-122	432.00
IUUC-Pfo-096451	Poecilia formosa	67.75	0.00e+00	1288.00
IUUC-Pab-098016	Pongo abelii	90.43	0.00e+00	1733.00
IUUC-Pca-100416	Procavia capensis	80.11	0.00e+00	1486.00
IUUC-Pva-102630	Pteropus vampyrus	88.11	0.00e+00	1651.00
IUUC-Sha-107116	Sarcophilus harrisii	84.91	0.00e+00	1605.00
IUUC-Smo-108747	Selaginella moellendorffii	40.00	3.00e-112	399.00
IUUC-Sar-113361	Sorex araneus	76.22	0.00e+00	1355.00
IUUC-Ssc-115516	Sus scrofa	87.92	0.00e+00	1661.00
IUUC-Tgu-117386	Taeniopygia guttata	76.30	0.00e+00	1451.00
IUUC-Tru-117680	Takifugu rubripes	67.53	0.00e+00	1252.00
IUUC-Tsy-119137	Tarsius syrichta	88.89	0.00e+00	1664.00
IUUC-Tni-120537	Tetraodon nigroviridis	66.13	0.00e+00	1284.00
IUUC-Tbe-127862	Tupaia belangeri	79.22	0.00e+00	1424.00
IUUC-Ttr-128350	Tursiops truncatus	84.19	0.00e+00	1558.00
IUUC-Xtr-131946	Xenopus tropicalis	70.98	0.00e+00	1310.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence