iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046492

Ensembl Protein ID

ENSP00000349785.3

UniProt Accession

Q9BXW4; A0PJY8; A2RUP0; MLP3C_HUMAN

Genbank Protein ID

AAK35152.1; AAI27723.1; AAI32987.1; AAI32989.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3C; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; MAP1A/MAP1B light chain 3 C; Microtubule-associated protein 1 light chain 3 gamma

Genbank Nucleotide ID

AF276659; BX571673; BC132986; BC132988

Gene Name

MAP1LC3C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197769.5	ENST00000357246.3	ENSP00000349785.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG8	ATG8	23721406

Classification

Family	E-value	Score	Start	End
ULD/UBL/ATG8	1.40e-48	165.0	22	126

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 2    rkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeekdedg 91
           r+eev+ ir+kfp+kiPv+ve++++e++ p ldk+k+lvP++lt++q+++iir+r++lra++a++llvnn slvs+sat+aeiy+++kdedg
   Q: 22   RQEEVAGIRAKFPNKIPVVVERYPRETFlPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNkSLVSMSATMAEIYRDYKDEDG 113
           89*************************99*****************************************9********************* PP
   S: 92   flyvayaseetfG 104
           f+y++yas+etfG
   Q: 114  FVYMTYASQETFG 126
           ************9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium.

Protein Sequence
(Fasta)

MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL PPLDKTKFLV 60
PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT MAEIYRDYKD EDGFVYMTYA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAGGTTCC CGGTTGCGGG ACAGTTTTTT TTTCTTTTTT AAAACAGACA CAGCTACTGA 60
GTGCAATGCC GCCTCCACAG AAAATCCCAA GCGTCAGACC CTTCAAGCAG AGGAAAAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR027731--MAP1A/MAP1B_LC3C
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005874--C:microtubule
GO:0031090--C:organelle membrane
GO:0000932--C:P-body
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0016236--P:macroautophagy

KEGG

hsa:440738

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001289	Ailuropoda melanoleuca	84.00	7.00e-59	219.00
IUUC-Apl-004191	Anas platyrhynchos	81.65	2.00e-50	190.00
IUUC-Aca-005135	Anolis carolinensis	75.40	1.00e-52	198.00
IUUC-Ame-011476	Astyanax mexicanus	65.67	4.00e-51	192.00
IUUC-Bta-012610	Bos taurus	85.14	2.00e-69	253.00
IUUC-Cja-019805	Callithrix jacchus	93.20	4.00e-77	279.00
IUUC-Cfa-020204	Canis familiaris	86.92	2.00e-62	231.00
IUUC-Csa-023481	Chlorocebus sabaeus	97.28	1.00e-80	291.00
IUUC-Csv-026146	Ciona savignyi	57.94	3.00e-39	153.00
IUUC-Dre-028789	Danio rerio	72.22	1.00e-52	198.00
IUUC-Eeu-034935	Erinaceus europaeus	78.23	5.00e-65	239.00
IUUC-Fal-036962	Ficedula albicollis	76.92	1.00e-54	205.00
IUUC-Gmo-038883	Gadus morhua	68.50	8.00e-49	185.00
IUUC-Gga-040716	Gallus gallus	80.99	6.00e-56	209.00
IUUC-Gac-042077	Gasterosteus aculeatus	66.41	9.00e-48	181.00
IUUC-Ggo-045016	Gorilla gorilla	99.32	2.00e-82	297.00
IUUC-Itr-047874	Ictidomys tridecemlineatus	87.41	1.00e-66	244.00
IUUC-Lch-050056	Latimeria chalumnae	58.59	4.00e-41	159.00
IUUC-Loc-052364	Lepisosteus oculatus	72.93	1.00e-53	201.00
IUUC-Laf-054399	Loxodonta africana	88.33	5.00e-60	222.00
IUUC-Mcc-055190	Macaca mulatta	93.20	6.00e-77	279.00
IUUC-Meu-056679	Macropus eugenii	85.04	4.00e-61	226.00
IUUC-Mga-059810	Meleagris gallopavo	82.86	9.00e-50	188.00
IUUC-Mmr-060763	Microcebus murinus	90.48	4.00e-75	273.00
IUUC-Mdo-062341	Monodelphis domestica	88.14	1.00e-58	218.00
IUUC-Mpu-066764	Mustela putorius furo	82.44	6.00e-61	226.00
IUUC-Nle-069372	Nomascus leucogenys	99.32	2.00e-82	297.00
IUUC-Opr-071191	Ochotona princeps	84.51	4.00e-67	246.00
IUUC-Ont-071635	Oreochromis niloticus	69.75	2.00e-49	187.00
IUUC-Ocu-074647	Oryctolagus cuniculus	90.43	4.00e-44	169.00
IUUC-Ola-086326	Oryzias latipes	69.29	4.00e-50	189.00
IUUC-Oga-088081	Otolemur garnettii	89.47	2.00e-66	244.00
IUUC-Oar-089786	Ovis aries	85.81	4.00e-70	256.00
IUUC-Ptr-090903	Pan troglodytes	98.64	2.00e-82	297.00
IUUC-Pan-092167	Papio anubis	96.34	2.00e-43	166.00
IUUC-Psi-093864	Pelodiscus sinensis	74.24	4.00e-54	202.00
IUUC-Pfo-097172	Poecilia formosa	69.23	1.00e-47	181.00
IUUC-Pab-098144	Pongo abelii	94.56	3.00e-78	283.00
IUUC-Pca-100534	Procavia capensis	79.59	8.00e-65	238.00
IUUC-Pva-102650	Pteropus vampyrus	68.25	4.00e-44	169.00
IUUC-Sha-106953	Sarcophilus harrisii	83.46	3.00e-59	220.00
IUUC-Ssc-115242	Sus scrofa	85.16	6.00e-60	222.00
IUUC-Tgu-116714	Taeniopygia guttata	73.55	4.00e-49	186.00
IUUC-Tru-118015	Takifugu rubripes	70.94	5.00e-50	189.00
IUUC-Tsy-118976	Tarsius syrichta	86.99	2.00e-71	261.00
IUUC-Tni-120132	Tetraodon nigroviridis	71.43	5.00e-50	189.00
IUUC-Tbe-127489	Tupaia belangeri	85.03	7.00e-69	252.00
IUUC-Xtr-132388	Xenopus tropicalis	76.72	2.00e-50	190.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence