iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001636

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01035376

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000009403.1	ENSAMET00000010323.1	ENSAMEP00000009892.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-122	407.9	1044	1376

Active Site

Position(s)	Description	Evidence
1344	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1044 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1129
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1130 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1212
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1213 MVKWRVERGVVQQTEALVRGFCEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1299
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1300 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1376
           ************************999***********************************************985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MLVLLVSHFP SSFFLQIFKS IGSDETVQGQ GSRRLISFSL SDFQAMGLKK GMFFNPDPYL 60
KISIQPGKHS IFPALPHHGQ ERRSKIIGNT VNPIWQAEQF SFVSLPTDVL EIEVKDKFAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTTGTTT TGCTTGTCTC CCATTTTCCT TCTTCTTTTT TTTTTATGTT TTTTTATTAT 60
ATTATGTTAG TCACCATACA GTACATCCCT GGTTTCTGAT GTAAAGCTCG ATGATTCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003299	Anas platyrhynchos	78.12	0.00e+00	2072.00
IUUC-Aca-005024	Anolis carolinensis	83.84	0.00e+00	1702.00
IUUC-Bta-012604	Bos taurus	85.90	0.00e+00	2243.00
IUUC-Cja-019880	Callithrix jacchus	82.37	0.00e+00	2183.00
IUUC-Cfa-021216	Canis familiaris	92.14	0.00e+00	1815.00
IUUC-Cpo-021466	Cavia porcellus	96.55	0.00e+00	1716.00
IUUC-Csa-023080	Chlorocebus sabaeus	87.31	0.00e+00	2273.00
IUUC-Cho-024740	Choloepus hoffmanni	92.43	0.00e+00	1134.00
IUUC-Dre-028750	Danio rerio	73.57	0.00e+00	1540.00
IUUC-Dno-030019	Dasypus novemcinctus	85.14	0.00e+00	2234.00
IUUC-Dor-031030	Dipodomys ordii	72.78	0.00e+00	1125.00
IUUC-Ete-032352	Echinops telfairi	93.85	0.00e+00	1257.00
IUUC-Eca-033948	Equus caballus	87.77	0.00e+00	2216.00
IUUC-Eeu-034474	Erinaceus europaeus	70.35	0.00e+00	832.00
IUUC-Fca-036148	Felis catus	95.71	0.00e+00	1899.00
IUUC-Fal-036957	Ficedula albicollis	77.50	0.00e+00	2026.00
IUUC-Gmo-038714	Gadus morhua	75.15	0.00e+00	950.00
IUUC-Gga-041194	Gallus gallus	77.77	0.00e+00	2070.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.90	0.00e+00	1355.00
IUUC-Ggo-045442	Gorilla gorilla	77.20	0.00e+00	1976.00
IUUC-Hsa-045730	Homo sapiens	87.25	0.00e+00	2273.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	87.31	0.00e+00	2300.00
IUUC-Lch-050185	Latimeria chalumnae	66.76	0.00e+00	1655.00
IUUC-Loc-052744	Lepisosteus oculatus	72.73	0.00e+00	1851.00
IUUC-Laf-054368	Loxodonta africana	97.69	0.00e+00	1497.00
IUUC-Mcc-055487	Macaca mulatta	87.25	0.00e+00	2279.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	726.00
IUUC-Mga-059545	Meleagris gallopavo	78.64	0.00e+00	2065.00
IUUC-Mmr-061078	Microcebus murinus	90.35	0.00e+00	1797.00
IUUC-Mdo-062176	Monodelphis domestica	84.37	0.00e+00	1691.00
IUUC-Mmu-063513	Mus musculus	83.22	0.00e+00	2149.00
IUUC-Mpu-065786	Mustela putorius furo	91.50	0.00e+00	2353.00
IUUC-Mlu-067780	Myotis lucifugus	80.66	0.00e+00	2051.00
IUUC-Nle-069213	Nomascus leucogenys	86.62	0.00e+00	2271.00
IUUC-Opr-070208	Ochotona princeps	96.31	0.00e+00	1487.00
IUUC-Ont-072132	Oreochromis niloticus	80.57	0.00e+00	1353.00
IUUC-Oan-072807	Ornithorhynchus anatinus	86.70	0.00e+00	1769.00
IUUC-Ocu-074745	Oryctolagus cuniculus	86.26	0.00e+00	2177.00
IUUC-Ola-086981	Oryzias latipes	67.99	0.00e+00	1734.00
IUUC-Oga-087965	Otolemur garnettii	92.43	0.00e+00	1818.00
IUUC-Oar-089749	Ovis aries	91.00	0.00e+00	1863.00
IUUC-Ptr-091243	Pan troglodytes	87.18	0.00e+00	2272.00
IUUC-Pan-092201	Papio anubis	88.32	0.00e+00	2283.00
IUUC-Psi-093511	Pelodiscus sinensis	77.29	0.00e+00	2023.00
IUUC-Pfo-097001	Poecilia formosa	64.76	0.00e+00	1561.00
IUUC-Pab-098728	Pongo abelii	84.55	0.00e+00	2154.00
IUUC-Pca-100129	Procavia capensis	81.60	0.00e+00	1249.00
IUUC-Pva-102250	Pteropus vampyrus	77.46	0.00e+00	1923.00
IUUC-Rno-105031	Rattus norvegicus	83.35	0.00e+00	2170.00
IUUC-Tgu-117515	Taeniopygia guttata	78.52	0.00e+00	2073.00
IUUC-Tru-117914	Takifugu rubripes	75.13	0.00e+00	1358.00
IUUC-Tsy-119379	Tarsius syrichta	79.17	0.00e+00	789.00
IUUC-Tni-120178	Tetraodon nigroviridis	75.34	0.00e+00	1373.00
IUUC-Tbe-127762	Tupaia belangeri	86.21	0.00e+00	1717.00
IUUC-Ttr-128806	Tursiops truncatus	92.72	0.00e+00	1738.00
IUUC-Xtr-132903	Xenopus tropicalis	75.24	0.00e+00	1851.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence