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Tag Content
UUCD2 ID IUUC-Xtr-132729
UUCD1 version UUC-XeT-01069
Ensembl Protein ID ENSXETP00000061641.1
UniProt Accession F6Z5C0; B2GUK6; F6ZNA0; UBP15_XENTR
Genbank Protein ID AAI66318.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15
Genbank Nucleotide ID AAMC01103598
Gene Name usp15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000021472.4 ENSXETT00000066127.1 ENSXETP00000061641.1
ENSXETG00000021472.4 ENSXETT00000046428.3 ENSXETP00000046428.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.50e-101 338.6 288 929
ULD/UDP/UBQ/UBQ_Other 2.90e-06 27.2 147 216
Active Site
Position(s) Description Evidence
297 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
891 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS++Q+ +  + l++ + +    ++n ++p  +k + ++ l+  f++++  +     +p+ +++ ++++a++fsgy+
   Q: 288  CGLSNLGNTCFMNSAIQVRMISKYLKNTMYN---IHFNYKSP-YSKLSWYCRLHLRFASILwRYIFAFLNPKVFTTEVGRFAPQFSGYQ 372
           7*****************************9...55555543.5677888888877777644*************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ ++kp+ +++++d   ++d+     a+e++ k+n+s+i+d+F+g +ks+++c+ec ++s++++pf++l
   Q: 373  QQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKvvaeeAWENHIKRNDSIIVDIFHGLFKSTLVCPECSKISVTFDPFCYL 459
           ******************************9999..5555555777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+e+++e                                                                            
   Q: 460  TLPLPMKKERALEvylvrmdplakpmqykvivpkignimdlctalsslsgiapekmvvtdiynhrfhrifamdenlssimerddiyvfe 548
           *********9999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 549  tsinrtedteqviipvylrekfrhtsyshhhgstlfgqpflitvprnitedklynllllrmcryvkatndteendgslhcnkehtvngn 637
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 638  gpngiheegspsemetdepddessqdqelpsenensqsedsvggdndsenglctedtckgqsvtgqkkrlftfqfsnlgssdityikdd 726
           ***************************************************************************************** PP
   S: 186  ........................................................slqdcLesftkeeelegenkyycekckkkqeae 218
                                                                   +l+dc+e ft++e+l  e+ +yc++ck++q+a+
   Q: 727  tkyirfderqlrldersylaldwdpklkkkffdenaaedfekhesvdftpqkkafmKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQAT 815
           ***************************************************************************************** PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk. 305
           kkl+l++lP+vL++hLkRfs+s+  ++r k+++ v+fp++ Ld+s f+++p+ +   ++ Y+Liav +H+G++++GHY+a++kn++++ 
   Q: 816  KKLDLWSLPPVLVVHLKRFSYSR--YMRDKLDTLVDFPISdLDMSTFLINPNAG---PCCYNLIAVSNHYGGMGGGHYTAFAKNKDDGk 899
           *******************9977..6999*********************9988...8**************************65555 PP
   S: 306  WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           W++fdDs+V++ +ee++++   + aYvlfY+r+
   Q: 900  WYYFDDSSVSTASEEQIVS---KAAYVLFYQRQ 929
           *******************...*********96 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekks 74
           + t++++++dt+  + +++++ ++ip + + rL++k      ++L ++  t++d gl++g+ +++++k+ 
   Q: 147  VVTRRFSKADTIDMIEKEMRTIFSIPdEKETRLWNKymsntFEPLnKPESTIQDAGLYQGQMLVIEQKNQ 216
           77899*********************999*****998875544569******************999986 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of tgfbr1, leading to an enhanced TGF-beta signal. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B.
 Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of tgfbr1, leading to an enhanced TGF-beta signal. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B.
Protein Sequence
(Fasta)
MAEGGVVDLE TQRSEVSALL KTPLRRGDTW YLIDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LKDTDTQSLK EHLIDELDYI LLPTEGWNKL VSWYSVVESQ QPIARKVVEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132729|DUB,USP;ULD,UBQ_Other|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGAGG GCGGAGTGGT GGATCTGGAG ACTCAGAGAT CCGAAGTGTC AGCCCTGCTG 60
AAAACCCCTC TCAGAAGAGG AGACACCTGG TAAGCATGAG CGAGCACAGC GGGGAGATGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132729|DUB,USP;ULD,UBQ_Other|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2
SMART

SM00695--DUSP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030509--P:BMP signaling pathway
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG xtr:100158604
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001852 Ailuropoda melanoleuca 83.54 0.00e+00 1611.00
IUUC-Apl-003249 Anas platyrhynchos 84.16 0.00e+00 1514.00
IUUC-Aca-004261 Anolis carolinensis 83.61 0.00e+00 1535.00
IUUC-Ame-010757 Astyanax mexicanus 74.07 0.00e+00 1174.00
IUUC-Bta-013128 Bos taurus 80.96 0.00e+00 1589.00
IUUC-Cja-019222 Callithrix jacchus 84.03 0.00e+00 1617.00
IUUC-Cfa-020035 Canis familiaris 83.54 0.00e+00 1610.00
IUUC-Cpo-022071 Cavia porcellus 83.62 0.00e+00 1544.00
IUUC-Csa-023882 Chlorocebus sabaeus 84.13 0.00e+00 1620.00
IUUC-Csv-026109 Ciona savignyi 40.29 7.00e-179 620.00
IUUC-Dno-029025 Dasypus novemcinctus 79.12 0.00e+00 1518.00
IUUC-Dor-030956 Dipodomys ordii 88.78 0.00e+00 1070.00
IUUC-Eca-034340 Equus caballus 84.26 0.00e+00 1571.00
IUUC-Eeu-034488 Erinaceus europaeus 73.33 0.00e+00 1037.00
IUUC-Fca-035552 Felis catus 81.06 0.00e+00 1583.00
IUUC-Fal-036618 Ficedula albicollis 84.05 0.00e+00 1508.00
IUUC-Gga-041146 Gallus gallus 83.32 0.00e+00 1551.00
IUUC-Gac-041679 Gasterosteus aculeatus 71.79 0.00e+00 1364.00
IUUC-Ggo-045002 Gorilla gorilla 84.59 0.00e+00 1569.00
IUUC-Hsa-046052 Homo sapiens 84.23 0.00e+00 1622.00
IUUC-Itr-048306 Ictidomys tridecemlineatus 81.50 0.00e+00 1595.00
IUUC-Lch-050107 Latimeria chalumnae 79.86 0.00e+00 1632.00
IUUC-Loc-052105 Lepisosteus oculatus 75.91 0.00e+00 1399.00
IUUC-Laf-053645 Loxodonta africana 83.13 0.00e+00 1607.00
IUUC-Mcc-055586 Macaca mulatta 84.23 0.00e+00 1622.00
IUUC-Meu-056764 Macropus eugenii 81.83 0.00e+00 936.00
IUUC-Mga-060162 Meleagris gallopavo 83.52 0.00e+00 1555.00
IUUC-Mmr-061105 Microcebus murinus 84.03 0.00e+00 1618.00
IUUC-Mdo-062107 Monodelphis domestica 83.32 0.00e+00 1605.00
IUUC-Mmu-063662 Mus musculus 83.21 0.00e+00 1610.00
IUUC-Mpu-065868 Mustela putorius furo 81.95 0.00e+00 1603.00
IUUC-Mlu-068000 Myotis lucifugus 79.04 0.00e+00 1439.00
IUUC-Nle-069874 Nomascus leucogenys 84.42 0.00e+00 1605.00
IUUC-Opr-071212 Ochotona princeps 78.62 0.00e+00 1506.00
IUUC-Ont-071834 Oreochromis niloticus 73.58 0.00e+00 1359.00
IUUC-Ocu-074573 Oryctolagus cuniculus 84.13 0.00e+00 1622.00
IUUC-Oga-089022 Otolemur garnettii 81.26 0.00e+00 1593.00
IUUC-Oar-089767 Ovis aries 83.42 0.00e+00 1611.00
IUUC-Ptr-091319 Pan troglodytes 81.77 0.00e+00 1601.00
IUUC-Pan-091968 Papio anubis 84.13 0.00e+00 1620.00
IUUC-Psi-093849 Pelodiscus sinensis 82.64 0.00e+00 1514.00
IUUC-Pfo-097110 Poecilia formosa 73.24 0.00e+00 1373.00
IUUC-Pab-098664 Pongo abelii 84.13 0.00e+00 1620.00
IUUC-Pca-100359 Procavia capensis 71.54 0.00e+00 1184.00
IUUC-Pva-102394 Pteropus vampyrus 83.21 0.00e+00 1594.00
IUUC-Rno-105383 Rattus norvegicus 81.26 0.00e+00 1596.00
IUUC-Sha-107393 Sarcophilus harrisii 83.42 0.00e+00 1608.00
IUUC-Sar-113498 Sorex araneus 83.62 0.00e+00 1610.00
IUUC-Ssc-115285 Sus scrofa 83.64 0.00e+00 1610.00
IUUC-Tgu-116529 Taeniopygia guttata 83.83 0.00e+00 1568.00
IUUC-Tru-118298 Takifugu rubripes 73.06 0.00e+00 1382.00
IUUC-Tsy-119117 Tarsius syrichta 74.96 0.00e+00 956.00
IUUC-Tni-120093 Tetraodon nigroviridis 70.28 0.00e+00 1302.00
IUUC-Tur-126149 Triticum urartu 38.80 6.00e-104 372.00
IUUC-Tbe-127672 Tupaia belangeri 75.46 0.00e+00 1035.00
IUUC-Vpa-130469 Vicugna pacos 83.74 0.00e+00 1551.00
Created Date 25-Jun-2017

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