iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037275.14	ENSMUST00000035604.12	ENSMUSP00000036603.6
ENSMUSG00000037275.14	ENSMUST00000102711.8	ENSMUSP00000099772.2
ENSMUSG00000037275.14	ENSMUST00000134953.1	ENSMUSP00000116600.1
ENSMUSG00000037275.14	ENSMUST00000172035.7	ENSMUSP00000131842.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-41	138.2	62	99
UBD/Beta-Prp	2.60e-64	218.4	57	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd..tllvsGsdDgtikvWDlrtg 33
           gHt++v+++ f   ++  +l +++sdDgt+kvWD+ t 
   Q: 62   GHTERVSGFTFshhPGqyNLCATSSDDGTVKVWDVETK 99
           8************9666799**************9875 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcl 129
           + +l gh++ v+  +fs++     + +t+s+D+t+kvwd++t + v   + h++++ +l++sp+  d +vsG++  ++ ++ l+ +   
   Q: 57   VGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWSPTVkDLIVSGDEKGVVFCYWLNRNDSQ 145
           67899*************965677***************************************655**************977777777 PP
   S: 130  eetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl.ktgkllrtltgghtdsvyslsfdsng........................ 192
           + +++ + +++ c++ +p   nl++ G +D++v + d+ k g+++++l+g h+d ++s+++ + +                        
   Q: 146  H-LFT-EPRTIFCLTCSPHHeNLVAIGYKDGIVVIIDIsKKGEVIHRLRG-HDDEIHSIAWCPLSgedclsisqeenseepdipngkli 231
           6.555.555566666666555*****************999********9.*********666666667777777789999******** PP
   S: 193  ........kelvsgsldgtvklwdlqtgecvr 216
                    +l++gs+d+t+++w++++g+ v+
   Q: 232  aetpitkgCYLATGSKDQTIRIWSCSRGRGVM 263
           ******99******************997665 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MKPEPRTLPP SPNWYCSRCS DAAPGGIFGF AARTSVFLVR VGPGAGASPG APPFRVVGEL 60
VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKVWDVETKT VVTEHTLHQH TISALHWSPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATCGATCC CGCCCCCTCC CGCTCCACGC CGCGGTTGCG AACCACCGTC CCAGAGCTCC 60
TCTGCTGAGC TTGGGCGGCC GCGGAGATGA AGCCGGAGCC GCGGACGCTG CCGCCGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0022625--C:cytosolic large ribosomal subunit
GO:0016020--C:membrane
GO:0016604--C:nuclear body
GO:0032797--C:SMN complex
GO:0034718--C:SMN-Gemin2 complex
GO:0034719--C:SMN-Sm protein complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0043022--F:ribosome binding
GO:0000340--F:RNA 7-methylguanosine cap binding
GO:0030619--F:U1 snRNA binding
GO:0030621--F:U4 snRNA binding
GO:0030622--F:U4atac snRNA binding
GO:0006417--P:regulation of translation
GO:0000387--P:spliceosomal snRNP assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001199	Ailuropoda melanoleuca	81.65	0.00e+00	2430.00
IUUC-Apl-003586	Anas platyrhynchos	61.42	0.00e+00	1628.00
IUUC-Aca-004956	Anolis carolinensis	62.36	0.00e+00	1885.00
IUUC-Ame-010753	Astyanax mexicanus	62.50	0.00e+00	1002.00
IUUC-Bta-012315	Bos taurus	80.47	0.00e+00	2419.00
IUUC-Cja-019334	Callithrix jacchus	81.19	0.00e+00	2460.00
IUUC-Cfa-021254	Canis familiaris	81.43	0.00e+00	2482.00
IUUC-Cpo-021984	Cavia porcellus	78.74	0.00e+00	2240.00
IUUC-Csa-023650	Chlorocebus sabaeus	81.82	0.00e+00	2438.00
IUUC-Cho-024860	Choloepus hoffmanni	76.44	0.00e+00	2236.00
IUUC-Cin-025778	Ciona intestinalis	37.38	0.00e+00	668.00
IUUC-Csv-026313	Ciona savignyi	40.82	1.00e-163	570.00
IUUC-Dre-028096	Danio rerio	63.03	0.00e+00	1004.00
IUUC-Dno-029799	Dasypus novemcinctus	84.39	0.00e+00	2143.00
IUUC-Dor-030885	Dipodomys ordii	71.52	0.00e+00	1071.00
IUUC-Ete-032918	Echinops telfairi	75.94	0.00e+00	2256.00
IUUC-Eca-034144	Equus caballus	80.67	0.00e+00	2360.00
IUUC-Eeu-034843	Erinaceus europaeus	73.83	0.00e+00	1692.00
IUUC-Fca-035948	Felis catus	81.48	0.00e+00	2425.00
IUUC-Fal-037303	Ficedula albicollis	61.62	0.00e+00	1798.00
IUUC-Gmo-039591	Gadus morhua	47.58	0.00e+00	1059.00
IUUC-Gga-040570	Gallus gallus	61.82	0.00e+00	1624.00
IUUC-Gac-042646	Gasterosteus aculeatus	48.93	0.00e+00	1363.00
IUUC-Ggo-045605	Gorilla gorilla	76.69	0.00e+00	1768.00
IUUC-Hsa-046122	Homo sapiens	82.08	0.00e+00	2445.00
IUUC-Itr-048094	Ictidomys tridecemlineatus	87.02	0.00e+00	2206.00
IUUC-Lch-050489	Latimeria chalumnae	50.62	0.00e+00	877.00
IUUC-Loc-052259	Lepisosteus oculatus	50.73	0.00e+00	1407.00
IUUC-Laf-053338	Loxodonta africana	80.65	0.00e+00	2417.00
IUUC-Mcc-055442	Macaca mulatta	81.95	0.00e+00	2438.00
IUUC-Meu-056245	Macropus eugenii	81.52	0.00e+00	861.00
IUUC-Mga-060202	Meleagris gallopavo	62.85	0.00e+00	1717.00
IUUC-Mmr-061730	Microcebus murinus	82.13	0.00e+00	2436.00
IUUC-Mdo-062880	Monodelphis domestica	71.17	0.00e+00	2126.00
IUUC-Mpu-066605	Mustela putorius furo	80.74	0.00e+00	2428.00
IUUC-Mlu-067765	Myotis lucifugus	82.00	0.00e+00	2481.00
IUUC-Nle-069183	Nomascus leucogenys	82.01	0.00e+00	2402.00
IUUC-Opr-070659	Ochotona princeps	70.88	0.00e+00	1082.00
IUUC-Ont-072356	Oreochromis niloticus	61.90	0.00e+00	1010.00
IUUC-Oan-073056	Ornithorhynchus anatinus	68.06	0.00e+00	1942.00
IUUC-Ocu-073881	Oryctolagus cuniculus	81.90	0.00e+00	2497.00
IUUC-Ola-087120	Oryzias latipes	57.97	3.00e-68	251.00
IUUC-Olu-087648	Ostreococcus lucimarinus	24.43	2.00e-30	128.00
IUUC-Oga-088343	Otolemur garnettii	82.23	0.00e+00	2464.00
IUUC-Oar-089257	Ovis aries	80.25	0.00e+00	2440.00
IUUC-Ptr-090497	Pan troglodytes	82.08	0.00e+00	2416.00
IUUC-Pan-092638	Papio anubis	81.90	0.00e+00	2434.00
IUUC-Psi-093096	Pelodiscus sinensis	63.12	0.00e+00	1619.00
IUUC-Pma-094571	Petromyzon marinus	42.74	2.00e-83	302.00
IUUC-Pfo-096348	Poecilia formosa	62.29	0.00e+00	980.00
IUUC-Pab-098153	Pongo abelii	81.68	0.00e+00	2466.00
IUUC-Pca-100957	Procavia capensis	75.35	0.00e+00	2246.00
IUUC-Pva-102439	Pteropus vampyrus	81.70	0.00e+00	2460.00
IUUC-Rno-105891	Rattus norvegicus	95.68	0.00e+00	2716.00
IUUC-Sha-107181	Sarcophilus harrisii	71.09	0.00e+00	2019.00
IUUC-Ssc-115413	Sus scrofa	80.34	0.00e+00	2463.00
IUUC-Tgu-117082	Taeniopygia guttata	62.46	0.00e+00	1768.00
IUUC-Tru-118491	Takifugu rubripes	59.72	0.00e+00	951.00
IUUC-Tsy-119629	Tarsius syrichta	91.35	2.00e-162	567.00
IUUC-Tni-120240	Tetraodon nigroviridis	59.45	0.00e+00	949.00
IUUC-Tbe-127673	Tupaia belangeri	72.03	0.00e+00	2005.00
IUUC-Ttr-128562	Tursiops truncatus	78.06	0.00e+00	2347.00
IUUC-Vpa-130596	Vicugna pacos	79.57	0.00e+00	1764.00
IUUC-Xtr-132469	Xenopus tropicalis	57.73	0.00e+00	1674.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence