iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044632

UUCD1 version

UUC-GoG-00787

Ensembl Protein ID

ENSGGOP00000020790.1

UniProt Accession

G3RYA3; G3RYA3_GORGO

Protein Name

Uncharacterized protein

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000015364.2	ENSGGOT00000023459.1	ENSGGOP00000020790.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-33	113.5	233	264
UBD/Beta-Prp	2.20e-56	191.6	56	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H ++++++++ +d t+l+s+s+D+t k+WD++
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDVS 264
           99*********999****************85 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++g
   Q: 56   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITG 144
           455666678*************************998777742334567***********99999999887777777789********* PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgg 178
           h++ + s+++ +s+ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d k+g+ +  l  +++
   Q: 145  HNKVINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKNGEKVCALggSKA 232
           ************999*****************9999998.99********************************************888 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvk.svrfspnderlvsgssDgsiriWdlrs.gdllktlqlhns 265
           h++ +y +s+++++++l+s+s d+t k+wd++ +++v t+   ++    ++  + ++++l+s+s  g i+  d  + +++l+++++h +
   Q: 233  HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDqQLGCLWQKDHLLSVSLSGYINYLDRNNpSKPLRVIKGHSK 321
           ****************************************97665554145555799999***********875443567777777777 PP
   S: 266  svisvavls 274
           s+ + +v++
   Q: 322  SIQCLTVHK 330
           777777654 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCAGCCGC CGAGCCGAGC GCTTGACTAT ATATGGTCAA AGCTGGGGGC GAGCCGCGCG 60
CGGGACCGCG CTTCCGGGTT CGGGGCGTCC GCAACGGCAG CGCGCAGGGC AGGCGCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	34.86	3.00e-78	285.00
IUUC-Aml-002368	Ailuropoda melanoleuca	94.52	0.00e+00	1150.00
IUUC-Atr-003160	Amborella trichopoda	36.59	4.00e-111	395.00
IUUC-Apl-004012	Anas platyrhynchos	85.67	0.00e+00	1048.00
IUUC-Aca-004707	Anolis carolinensis	81.38	0.00e+00	1025.00
IUUC-Aly-006465	Arabidopsis lyrata	36.20	4.00e-105	375.00
IUUC-Ath-006740	Arabidopsis thaliana	35.71	2.00e-104	372.00
IUUC-Ago-007920	Ashbya gossypii	27.36	5.00e-70	258.00
IUUC-Acl-008262	Aspergillus clavatus	35.55	1.00e-100	360.00
IUUC-Afl-008471	Aspergillus flavus	29.54	3.00e-66	246.00
IUUC-Afu-008989	Aspergillus fumigatus	37.16	1.00e-91	330.00
IUUC-Ani-009167	Aspergillus nidulans	37.48	2.00e-111	396.00
IUUC-Ang-009595	Aspergillus niger	36.64	3.00e-99	355.00
IUUC-Aor-009908	Aspergillus oryzae	36.41	2.00e-99	356.00
IUUC-Ate-010580	Aspergillus terreus	37.13	3.00e-104	374.00
IUUC-Ame-011269	Astyanax mexicanus	58.10	1.00e-125	443.00
IUUC-Bgr-011996	Blumeria graminis	33.82	4.00e-103	368.00
IUUC-Bta-013278	Bos taurus	93.74	0.00e+00	1180.00
IUUC-Bci-013925	Botrytis cinerea	35.28	3.00e-103	369.00
IUUC-Bdi-014659	Brachypodium distachyon	35.56	3.00e-100	358.00
IUUC-Bol-016043	Brassica oleracea	35.06	1.00e-103	370.00
IUUC-Bra-017139	Brassica rapa	35.45	1.00e-103	370.00
IUUC-Cel-018417	Caenorhabditis elegans	41.12	2.00e-120	426.00
IUUC-Cja-019952	Callithrix jacchus	95.88	0.00e+00	1144.00
IUUC-Cfa-020225	Canis familiaris	94.40	0.00e+00	1162.00
IUUC-Cpo-021900	Cavia porcellus	93.02	0.00e+00	1145.00
IUUC-Csa-023028	Chlorocebus sabaeus	97.20	0.00e+00	1156.00
IUUC-Cho-025030	Choloepus hoffmanni	68.55	0.00e+00	759.00
IUUC-Cin-025152	Ciona intestinalis	55.64	9.00e-81	293.00
IUUC-Csv-025986	Ciona savignyi	37.34	3.00e-89	322.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	37.56	4.00e-107	381.00
IUUC-Cne-026814	Cryptococcus neoformans	34.09	5.00e-95	341.00
IUUC-Dre-027498	Danio rerio	80.51	9.00e-96	342.00
IUUC-Dno-029383	Dasypus novemcinctus	93.41	0.00e+00	1120.00
IUUC-Dor-030633	Dipodomys ordii	94.47	0.00e+00	1101.00
IUUC-Dse-031526	Dothistroma septosporum	37.52	4.00e-112	398.00
IUUC-Dme-031597	Drosophila melanogaster	47.37	3.00e-163	568.00
IUUC-Ete-032780	Echinops telfairi	85.01	0.00e+00	1057.00
IUUC-Eca-034306	Equus caballus	95.01	0.00e+00	1161.00
IUUC-Eeu-034531	Erinaceus europaeus	76.71	4.00e-141	494.00
IUUC-Fca-036301	Felis catus	95.18	0.00e+00	1181.00
IUUC-Fal-037361	Ficedula albicollis	85.62	0.00e+00	1099.00
IUUC-Fox-037924	Fusarium oxysporum	34.80	5.00e-96	345.00
IUUC-Fso-038199	Fusarium solani	33.93	6.00e-93	334.00
IUUC-Gmo-039238	Gadus morhua	70.56	0.00e+00	868.00
IUUC-Ggr-039830	Gaeumannomyces graminis	34.79	2.00e-91	329.00
IUUC-Gga-040235	Gallus gallus	86.82	0.00e+00	1077.00
IUUC-Gac-042363	Gasterosteus aculeatus	70.07	0.00e+00	894.00
IUUC-Gma-044189	Glycine max	36.44	4.00e-110	392.00
IUUC-Hsa-045792	Homo sapiens	97.20	0.00e+00	1186.00
IUUC-Hvu-047517	Hordeum vulgare	34.85	2.00e-103	370.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	94.35	0.00e+00	1150.00
IUUC-Kpa-049183	Komagataella pastoris	32.18	4.00e-82	298.00
IUUC-Lch-050428	Latimeria chalumnae	74.39	0.00e+00	975.00
IUUC-Lpe-051306	Leersia perrieri	34.91	3.00e-104	372.00
IUUC-Loc-052096	Lepisosteus oculatus	69.85	0.00e+00	874.00
IUUC-Lma-053313	Leptosphaeria maculans	38.73	9.00e-113	403.00
IUUC-Laf-054060	Loxodonta africana	91.19	0.00e+00	1126.00
IUUC-Mcc-055619	Macaca mulatta	97.87	0.00e+00	1170.00
IUUC-Meu-056689	Macropus eugenii	78.70	0.00e+00	643.00
IUUC-Mor-056940	Magnaporthe oryzae	34.30	2.00e-92	333.00
IUUC-Mpo-057557	Magnaporthe poae	28.00	6.00e-53	201.00
IUUC-Mtr-057922	Medicago truncatula	35.77	2.00e-107	383.00
IUUC-Mla-059103	Melampsora laricipopulina	32.75	6.00e-73	268.00
IUUC-Mga-060150	Meleagris gallopavo	86.45	0.00e+00	1065.00
IUUC-Mvi-060448	Microbotryum violaceum	30.21	1.00e-72	267.00
IUUC-Mmr-061226	Microcebus murinus	94.23	0.00e+00	1157.00
IUUC-Mdo-062674	Monodelphis domestica	90.28	0.00e+00	1121.00
IUUC-Mmu-064170	Mus musculus	93.25	0.00e+00	1152.00
IUUC-Mac-065124	Musa acuminata	36.60	4.00e-109	388.00
IUUC-Mpu-066001	Mustela putorius furo	91.75	0.00e+00	1149.00
IUUC-Mlu-067253	Myotis lucifugus	92.36	0.00e+00	1146.00
IUUC-Nfi-068550	Neosartorya fischeri	37.16	2.00e-106	379.00
IUUC-Ncr-068948	Neurospora crassa	36.60	1.00e-111	397.00
IUUC-Nle-070115	Nomascus leucogenys	97.89	0.00e+00	1126.00
IUUC-Opr-070254	Ochotona princeps	94.18	0.00e+00	1123.00
IUUC-Ont-071666	Oreochromis niloticus	73.64	0.00e+00	928.00
IUUC-Oan-073594	Ornithorhynchus anatinus	89.22	4.00e-160	556.00
IUUC-Ocu-074824	Oryctolagus cuniculus	92.09	0.00e+00	1105.00
IUUC-Oba-075010	Oryza barthii	35.29	2.00e-105	376.00
IUUC-Obr-076364	Oryza brachyantha	35.77	4.00e-106	378.00
IUUC-Ogl-077019	Oryza glaberrima	35.29	2.00e-105	376.00
IUUC-Ogu-078496	Oryza glumaepatula	35.29	2.00e-105	376.00
IUUC-Oin-080116	Oryza indica	35.46	6.00e-106	378.00
IUUC-Olo-080290	Oryza longistaminata	35.29	4.00e-105	375.00
IUUC-Ome-081969	Oryza meridionalis	35.29	2.00e-105	376.00
IUUC-Oni-082075	Oryza nivara	35.29	2.00e-105	376.00
IUUC-Opu-083959	Oryza punctata	35.34	2.00e-105	375.00
IUUC-Oru-084711	Oryza rufipogon	35.29	2.00e-105	376.00
IUUC-Osa-085958	Oryza sativa	35.46	6.00e-106	378.00
IUUC-Ola-086968	Oryzias latipes	74.79	0.00e+00	944.00
IUUC-Oga-089108	Otolemur garnettii	94.45	0.00e+00	1199.00
IUUC-Oar-089986	Ovis aries	87.73	0.00e+00	1083.00
IUUC-Ptr-091281	Pan troglodytes	97.50	0.00e+00	1175.00
IUUC-Pan-092585	Papio anubis	97.36	0.00e+00	1159.00
IUUC-Psi-093811	Pelodiscus sinensis	84.25	0.00e+00	1082.00
IUUC-Pma-094396	Petromyzon marinus	69.11	0.00e+00	892.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.24	8.00e-106	377.00
IUUC-Ppa-095876	Physcomitrella patens	35.62	9.00e-107	380.00
IUUC-Pfo-096973	Poecilia formosa	72.98	0.00e+00	960.00
IUUC-Pab-098391	Pongo abelii	97.03	0.00e+00	1161.00
IUUC-Pop-098850	Populus trichocarpa	35.82	1.00e-108	387.00
IUUC-Pca-100257	Procavia capensis	63.64	6.00e-100	358.00
IUUC-Ppe-101578	Prunus persica	37.18	4.00e-112	398.00
IUUC-Pva-102872	Pteropus vampyrus	90.28	0.00e+00	1140.00
IUUC-Pgr-103593	Puccinia graminis	32.95	3.00e-76	279.00
IUUC-Pte-104365	Pyrenophora teres	38.93	8.00e-110	390.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.61	2.00e-112	399.00
IUUC-Rno-105737	Rattus norvegicus	93.90	0.00e+00	1188.00
IUUC-Sce-106383	Saccharomyces cerevisiae	28.48	1.00e-63	237.00
IUUC-Sha-107084	Sarcophilus harrisii	88.41	0.00e+00	985.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	34.26	1.00e-105	377.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.22	8.00e-92	331.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	34.96	8.00e-103	367.00
IUUC-Smo-109255	Selaginella moellendorffii	33.72	9.00e-96	344.00
IUUC-Sit-109962	Setaria italica	36.48	8.00e-108	384.00
IUUC-Sly-110897	Solanum lycopersicum	37.66	1.00e-113	403.00
IUUC-Stu-111971	Solanum tuberosum	37.66	3.00e-113	402.00
IUUC-Sar-113415	Sorex araneus	72.69	3.00e-109	389.00
IUUC-Sbi-114857	Sorghum bicolor	36.42	6.00e-106	377.00
IUUC-Sre-114900	Sporisorium reilianum	32.63	8.00e-88	317.00
IUUC-Tgu-117256	Taeniopygia guttata	85.41	0.00e+00	1090.00
IUUC-Tru-117871	Takifugu rubripes	68.32	0.00e+00	862.00
IUUC-Tsy-119172	Tarsius syrichta	97.08	2.00e-139	489.00
IUUC-Tni-120339	Tetraodon nigroviridis	68.53	0.00e+00	899.00
IUUC-Tca-121609	Theobroma cacao	36.46	2.00e-110	393.00
IUUC-Tre-122076	Trichoderma reesei	35.12	4.00e-91	328.00
IUUC-Tvi-122528	Trichoderma virens	33.93	1.00e-92	333.00
IUUC-Tae-123530	Triticum aestivum	35.23	7.00e-105	374.00
IUUC-Tur-126845	Triticum urartu	33.95	3.00e-76	279.00
IUUC-Tme-127217	Tuber melanosporum	35.10	1.00e-101	363.00
IUUC-Tbe-127526	Tupaia belangeri	95.05	0.00e+00	1184.00
IUUC-Ttr-128898	Tursiops truncatus	88.80	0.00e+00	1118.00
IUUC-Uma-129631	Ustilago maydis	31.49	7.00e-91	328.00
IUUC-Vda-129732	Verticillium dahliae	34.65	1.00e-88	320.00
IUUC-Vvi-131217	Vitis vinifera	37.64	8.00e-111	394.00
IUUC-Xtr-132860	Xenopus tropicalis	73.58	0.00e+00	933.00
IUUC-Xma-133830	Xiphophorus maculatus	73.31	0.00e+00	963.00
IUUC-Yli-134335	Yarrowia lipolytica	31.92	2.00e-73	270.00
IUUC-Zma-135907	Zea mays	36.42	1.00e-106	380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence