iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028496

Ensembl Protein ID

ENSDARP00000096817.3

UniProt Accession

E7F3M3; E7F3M3_DANRE

Genbank Protein ID

ENSDARP00000096817

Protein Name

Rho guanine nucleotide exchange factor (GEF) 37

Genbank Nucleotide ID

CU074314

Gene Name

arhgef37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000002463.9	ENSDART00000106039.4	ENSDARP00000096817.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.60e-12	46.1	640	697

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v + yd++a +  eL+l++G+ v+v+   ++  +++W     e++g+rG +P+n+ + l
   Q: 640  QVYAGYDFTARSAHELSLRAGEPVRVVepHDKRGNKEWSLV--EARGQRGYVPSNYLTLL 697
           57788**********************8878889*****77..9************8765 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MANSLKANIT LTLDEEKEGA KEMENALEEL AEEEEDKEER KARVAAEEAA ARERAAQRQL 60
MAIEEMVHTE KNYLKHLQIC TVTINSNLQK LQPPPPNLEN MFQHIDEVME VSSRLLSLLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGATGTCT CTGTAATACA GATCAACGCT CGAGCAAACC TAAAGTACAG CACGCGTATA 60
TTTCTTGACA ACGGTTTGTC CTCTTATTTT TTCAATCCCT CGTGTGATTA ATCGATACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF00621--RhoGEF
PF14604--SH3_9

SMART

SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

dre:101883655

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	81.38	0.00e+00	1120.00
IUUC-Bta-012848	Bos taurus	38.52	3.00e-119	422.00
IUUC-Cfa-021281	Canis familiaris	40.28	1.00e-126	447.00
IUUC-Csa-023043	Chlorocebus sabaeus	39.66	3.00e-123	436.00
IUUC-Ggo-044900	Gorilla gorilla	39.29	1.00e-123	436.00
IUUC-Hsa-045684	Homo sapiens	39.14	7.00e-127	447.00
IUUC-Lch-050096	Latimeria chalumnae	44.99	1.00e-157	550.00
IUUC-Loc-051937	Lepisosteus oculatus	60.85	0.00e+00	777.00
IUUC-Mcc-054950	Macaca mulatta	40.19	2.00e-123	436.00
IUUC-Meu-056383	Macropus eugenii	40.67	5.00e-88	318.00
IUUC-Mdo-062021	Monodelphis domestica	41.14	6.00e-135	474.00
IUUC-Mmu-064186	Mus musculus	40.49	3.00e-122	432.00
IUUC-Ptr-090508	Pan troglodytes	39.45	3.00e-125	442.00
IUUC-Pan-092517	Papio anubis	39.54	6.00e-122	431.00
IUUC-Pfo-096703	Poecilia formosa	63.76	0.00e+00	827.00
IUUC-Pab-098542	Pongo abelii	39.45	3.00e-124	439.00
IUUC-Rno-105455	Rattus norvegicus	40.21	1.00e-128	453.00
IUUC-Sha-106562	Sarcophilus harrisii	41.24	8.00e-133	467.00
IUUC-Ttr-128242	Tursiops truncatus	38.62	3.00e-118	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence