iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036295

Ensembl Protein ID

ENSFCAP00000023704.1

UniProt Accession

M3XAQ0; M3XAQ0_FELCA

Genbank Protein ID

ENSFCAP00000023704

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02197162

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000023528.1	ENSFCAT00000022293.1	ENSFCAP00000023704.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-80	269.9	3541	3900

Active Site

Position(s)	Description	Evidence
3874	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3541 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3623
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei..............lgetk 152
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                + +
   Q: 3624 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspegpkpccrftylTMTGE 3708
           **************************************66666677799999999999999532..33469*********6555556 PP
   S: 153  eeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykgg 238
           e+eL+++G++ipV++eNk+ Y  ++ ++rl+e + +e+v+a+r+G+  vipl+ll+ +++ e+el +cG ++i++e lk++t+y+ g
   Q: 3709 EVELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNAECVTAVRAGLGAVIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQVG 3795
           667*****************************9****************************************************** PP
   S: 239  ytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPe 312
           ++e++++i++Fw +le f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP+
   Q: 3796 LMETDQHIEFFWGALEVFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLPQ 3882
           ********************************************99999999988888888889955555***************** PP
   S: 313  YsskeilkekLlyAieet 330
           Yss ei+ ekL++Ai+++
   Q: 3883 YSSLEIMLEKLRCAIHYR 3900
           ***************986 PP

Organism

Felis catus

Protein Sequence
(Fasta)

ANTSCGLPLK MLRKTPIYTC GTYLVMLVPP PGGAGSSATR SLFGGTSGLS SLKILASSLV 60
YNISDGQFTS RADLIDAAGS SLGRGALVPG LGACYDTVNN MLWTCSNDYI DQWCNPGNQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTTTCATC CCTTTCACCA GCAAATACTA GCTGTGGGCT GCCTCTGAAA ATGCTGCGGA 60
AGACGCCCAT CTATACGTGC GGCACGTACT TGGTGATGCT GGTCCCACCG CCAGGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.17	0.00e+00	7029.00
IUUC-Apl-004161	Anas platyrhynchos	92.59	0.00e+00	5168.00
IUUC-Aca-005341	Anolis carolinensis	88.46	0.00e+00	6410.00
IUUC-Ame-011574	Astyanax mexicanus	83.23	0.00e+00	4415.00
IUUC-Bta-012514	Bos taurus	97.33	0.00e+00	1916.00
IUUC-Cja-019148	Callithrix jacchus	96.29	0.00e+00	5276.00
IUUC-Cfa-020499	Canis familiaris	98.57	0.00e+00	7145.00
IUUC-Cpo-021894	Cavia porcellus	97.18	0.00e+00	2771.00
IUUC-Csa-023079	Chlorocebus sabaeus	97.62	0.00e+00	7112.00
IUUC-Cho-024415	Choloepus hoffmanni	93.10	0.00e+00	4855.00
IUUC-Dre-027452	Danio rerio	81.73	0.00e+00	4431.00
IUUC-Dno-029595	Dasypus novemcinctus	96.96	0.00e+00	7093.00
IUUC-Dor-030849	Dipodomys ordii	97.59	0.00e+00	1806.00
IUUC-Ete-032563	Echinops telfairi	89.95	0.00e+00	1624.00
IUUC-Eca-034202	Equus caballus	96.79	0.00e+00	6948.00
IUUC-Eeu-035175	Erinaceus europaeus	97.11	0.00e+00	1076.00
IUUC-Fal-037003	Ficedula albicollis	93.00	0.00e+00	6079.00
IUUC-Gmo-038579	Gadus morhua	85.03	0.00e+00	2887.00
IUUC-Gga-040961	Gallus gallus	93.07	0.00e+00	6860.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.70	0.00e+00	2915.00
IUUC-Ggo-045099	Gorilla gorilla	97.32	0.00e+00	6398.00
IUUC-Hsa-046331	Homo sapiens	97.40	0.00e+00	7154.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.38	0.00e+00	2178.00
IUUC-Lch-049923	Latimeria chalumnae	83.50	0.00e+00	2518.00
IUUC-Loc-052630	Lepisosteus oculatus	83.99	0.00e+00	4056.00
IUUC-Laf-053394	Loxodonta africana	97.29	0.00e+00	7166.00
IUUC-Mcc-055763	Macaca mulatta	97.70	0.00e+00	7115.00
IUUC-Meu-056039	Macropus eugenii	88.94	0.00e+00	5068.00
IUUC-Mga-059500	Meleagris gallopavo	91.31	0.00e+00	6726.00
IUUC-Mmr-060868	Microcebus murinus	93.89	0.00e+00	6840.00
IUUC-Mdo-062772	Monodelphis domestica	94.07	0.00e+00	6922.00
IUUC-Mmu-063606	Mus musculus	96.54	0.00e+00	7093.00
IUUC-Mpu-065860	Mustela putorius furo	96.96	0.00e+00	6910.00
IUUC-Mlu-067376	Myotis lucifugus	95.68	0.00e+00	5112.00
IUUC-Nle-069693	Nomascus leucogenys	94.96	0.00e+00	6923.00
IUUC-Opr-071065	Ochotona princeps	94.79	0.00e+00	1204.00
IUUC-Ont-072470	Oreochromis niloticus	82.86	0.00e+00	4465.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.05	0.00e+00	5204.00
IUUC-Ocu-074032	Oryctolagus cuniculus	95.77	0.00e+00	7043.00
IUUC-Ola-087433	Oryzias latipes	83.28	0.00e+00	1598.00
IUUC-Oga-088546	Otolemur garnettii	97.59	0.00e+00	6964.00
IUUC-Oar-089643	Ovis aries	91.40	0.00e+00	757.00
IUUC-Ptr-090504	Pan troglodytes	96.40	0.00e+00	7064.00
IUUC-Pan-092543	Papio anubis	97.54	0.00e+00	7101.00
IUUC-Psi-093952	Pelodiscus sinensis	89.04	0.00e+00	6610.00
IUUC-Pfo-096356	Poecilia formosa	84.32	0.00e+00	4517.00
IUUC-Pab-098240	Pongo abelii	97.60	0.00e+00	7103.00
IUUC-Pca-100994	Procavia capensis	97.36	0.00e+00	3002.00
IUUC-Pva-102263	Pteropus vampyrus	95.78	0.00e+00	6925.00
IUUC-Rno-104888	Rattus norvegicus	96.49	0.00e+00	7076.00
IUUC-Sha-106944	Sarcophilus harrisii	92.15	0.00e+00	6843.00
IUUC-Sar-113556	Sorex araneus	83.25	0.00e+00	968.00
IUUC-Ssc-116187	Sus scrofa	97.91	0.00e+00	5166.00
IUUC-Tgu-116655	Taeniopygia guttata	92.29	0.00e+00	5143.00
IUUC-Tru-118093	Takifugu rubripes	83.87	0.00e+00	3019.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.38	0.00e+00	1611.00
IUUC-Tbe-127962	Tupaia belangeri	91.63	0.00e+00	1205.00
IUUC-Ttr-128819	Tursiops truncatus	92.65	0.00e+00	2844.00
IUUC-Vpa-130482	Vicugna pacos	94.16	0.00e+00	4229.00
IUUC-Xtr-132222	Xenopus tropicalis	85.97	0.00e+00	6493.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence