iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062772

UUCD1 version

UUC-MoD-00079

Ensembl Protein ID

ENSMODP00000003668.3

UniProt Accession

F6Q2M1; F6Q2M1_MONDO

Protein Name

Uncharacterized protein

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000003022.3	ENSMODT00000003755.3	ENSMODP00000003672.3
ENSMODG00000003022.3	ENSMODT00000003751.3	ENSMODP00000003668.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-78	265.0	4054	4414

Active Site

Position(s)	Description	Evidence
4388	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +f+G+llg+a++
   Q: 4054 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFFGQLLGIAIR 4136
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+   dl+e d  +y+++++ ++ + e+++e+l+++++++  +  ++                 + 
   Q: 4137 ADVPLPLDLLPSFWKTLVGEPLDPdVDLQEADILTYNYVQKFENINdETELEALCAEIASQhlA--TEspdspnkpcckftylTMTG 4221
           ************************99************88777554277888888888888532..334689999****99655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV +eNk+ Y  ++ ++rl+e + + +v a+r+G+ ++ipl+ll+ +t+ e+el +cG ++i++e lk++t+y+ 
   Q: 4222 EEVELCSRGRHIPVGWENKDVYAMAIRNLRLRElQNHDCVMAVRAGLGSIIPLQLLTTLTPLEMELRTCGLPYINLEFLKAHTMYQV 4308
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 4309 GLMETDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 4395
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 4396 QYSSLEIMLEKLRCAIHYR 4414
           ****************986 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGSSAAAAAA AAAAAAADSA QWLSVKEETI FLHDGLIRVT DLAELPSEIL GAAEAADTDL 60
EILTFETKSP TELADRLRSV CGNQSNAYAR LLEYRLNALR GLWNAQRQLA LEEQHERENS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTATTCGCC TCTGGATCCC CCTGGTTTAG TGCAGAGCCA GTCACACTAA AGGTGGTTAA 60
TGAATGCTGA TTGACTGAAT GATCGAACAC AGTGCCTAGC CCAAGCAGAC ACTTCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	93.33	0.00e+00	6977.00
IUUC-Apl-004161	Anas platyrhynchos	93.39	0.00e+00	5180.00
IUUC-Aca-005341	Anolis carolinensis	88.77	0.00e+00	6603.00
IUUC-Ame-011574	Astyanax mexicanus	81.29	0.00e+00	5027.00
IUUC-Bta-012514	Bos taurus	92.25	0.00e+00	1832.00
IUUC-Cja-019148	Callithrix jacchus	93.38	0.00e+00	5065.00
IUUC-Cfa-020499	Canis familiaris	94.41	0.00e+00	7519.00
IUUC-Cpo-021894	Cavia porcellus	94.64	0.00e+00	2677.00
IUUC-Csa-023079	Chlorocebus sabaeus	94.61	0.00e+00	7677.00
IUUC-Cho-024415	Choloepus hoffmanni	90.35	0.00e+00	4922.00
IUUC-Dre-027452	Danio rerio	78.97	0.00e+00	5036.00
IUUC-Dno-029595	Dasypus novemcinctus	94.09	0.00e+00	7661.00
IUUC-Dor-030849	Dipodomys ordii	95.61	0.00e+00	1775.00
IUUC-Ete-032563	Echinops telfairi	85.83	0.00e+00	1543.00
IUUC-Eca-034202	Equus caballus	93.32	0.00e+00	6917.00
IUUC-Eeu-035175	Erinaceus europaeus	93.85	0.00e+00	1026.00
IUUC-Fca-036295	Felis catus	94.07	0.00e+00	6859.00
IUUC-Fal-037003	Ficedula albicollis	93.20	0.00e+00	6709.00
IUUC-Gmo-038579	Gadus morhua	83.68	0.00e+00	2822.00
IUUC-Gga-040961	Gallus gallus	93.46	0.00e+00	7745.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.26	0.00e+00	2858.00
IUUC-Ggo-045099	Gorilla gorilla	94.14	0.00e+00	6141.00
IUUC-Hsa-046331	Homo sapiens	94.33	0.00e+00	7545.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	91.54	0.00e+00	2024.00
IUUC-Lch-049923	Latimeria chalumnae	83.93	0.00e+00	2647.00
IUUC-Loc-052630	Lepisosteus oculatus	84.08	0.00e+00	4021.00
IUUC-Laf-053394	Loxodonta africana	94.12	0.00e+00	7341.00
IUUC-Mcc-055763	Macaca mulatta	94.16	0.00e+00	7691.00
IUUC-Meu-056039	Macropus eugenii	93.20	0.00e+00	5261.00
IUUC-Mga-059500	Meleagris gallopavo	91.96	0.00e+00	6962.00
IUUC-Mmr-060868	Microcebus murinus	91.26	0.00e+00	7481.00
IUUC-Mmu-063606	Mus musculus	93.60	0.00e+00	7738.00
IUUC-Mpu-065860	Mustela putorius furo	91.51	0.00e+00	6838.00
IUUC-Mlu-067376	Myotis lucifugus	93.50	0.00e+00	5196.00
IUUC-Nle-069693	Nomascus leucogenys	92.24	0.00e+00	7318.00
IUUC-Opr-071065	Ochotona princeps	92.80	0.00e+00	1186.00
IUUC-Ont-072470	Oreochromis niloticus	82.07	0.00e+00	4594.00
IUUC-Oan-073693	Ornithorhynchus anatinus	93.59	0.00e+00	5212.00
IUUC-Ocu-074032	Oryctolagus cuniculus	93.21	0.00e+00	7730.00
IUUC-Ola-087433	Oryzias latipes	82.49	0.00e+00	1588.00
IUUC-Oga-088546	Otolemur garnettii	94.35	0.00e+00	6701.00
IUUC-Oar-089643	Ovis aries	88.70	0.00e+00	723.00
IUUC-Ptr-090504	Pan troglodytes	93.36	0.00e+00	7013.00
IUUC-Pan-092543	Papio anubis	94.50	0.00e+00	7654.00
IUUC-Psi-093952	Pelodiscus sinensis	90.47	0.00e+00	6861.00
IUUC-Pfo-096356	Poecilia formosa	82.75	0.00e+00	5120.00
IUUC-Pab-098240	Pongo abelii	94.55	0.00e+00	7745.00
IUUC-Pca-100994	Procavia capensis	95.54	0.00e+00	2961.00
IUUC-Pva-102263	Pteropus vampyrus	92.60	0.00e+00	6917.00
IUUC-Rno-104888	Rattus norvegicus	93.32	0.00e+00	7219.00
IUUC-Sha-106944	Sarcophilus harrisii	96.46	0.00e+00	7342.00
IUUC-Sar-113556	Sorex araneus	83.73	0.00e+00	915.00
IUUC-Ssc-116187	Sus scrofa	94.24	0.00e+00	4970.00
IUUC-Tgu-116655	Taeniopygia guttata	92.82	0.00e+00	5115.00
IUUC-Tru-118093	Takifugu rubripes	83.40	0.00e+00	2969.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.32	0.00e+00	1602.00
IUUC-Tbe-127962	Tupaia belangeri	86.99	0.00e+00	1138.00
IUUC-Ttr-128819	Tursiops truncatus	89.03	0.00e+00	2734.00
IUUC-Vpa-130482	Vicugna pacos	91.96	0.00e+00	4336.00
IUUC-Xtr-132222	Xenopus tropicalis	86.45	0.00e+00	6545.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence