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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064349
UUCD1 version UUC-MuM-00742
Ensembl Protein ID ENSMUSP00000048780.7
UniProt Accession Q8CHG5; Q6P9Q1; Q80YC4; Q8C5W5; AREL1_MOUSE
Genbank Protein ID BAC41414.1; BAC36566.1; AAH49900.1; AAH60658.1
Protein Name Apoptosis-resistant E3 ubiquitin protein ligase 1; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1
Genbank Nucleotide ID AB093230; AK077015; BC049900; BC060658
Gene Name Arel1; Kiaa0317
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042350.13 ENSMUST00000163231.7 ENSMUSP00000129213.1
ENSMUSG00000042350.13 ENSMUST00000043169.13 ENSMUSP00000048780.7
ENSMUSG00000042350.13 ENSMUST00000163372.7 ENSMUSP00000130259.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.70e-100 337.8 485 822
Active Site
Position(s) Description Evidence
790 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++++++++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFaRFTDSNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslgga 571
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k +eL++gG+++pVtn+Nk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKIVELMTGGAQTPVTNANKI 657
           99***********************************99****99...9****999**99999999999******************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 658  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVSDFKAHAvVVGGSWHFREKVMRWFWAVVSSLTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
Protein Sequence
(Fasta)
MFYVIGGIIV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVD IPVTQEVLQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064349|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGCTCTTTC CGGCAAAGGC CAACCCGGAG GCGGAAGCTA CTTTGGGAAA CGTAAAAGCT 60
CCGAGCCGGC TCCTAACGCT GGCGGAGATC GACACTGGAG ATTTTTTTGG GGGGCGGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064349|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT
Pfam

PF00630--Filamin
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:68497
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001308 Ailuropoda melanoleuca 96.72 0.00e+00 1632.00
IUUC-Apl-004071 Anas platyrhynchos 90.77 0.00e+00 1475.00
IUUC-Aca-005218 Anolis carolinensis 90.53 0.00e+00 1494.00
IUUC-Ame-011871 Astyanax mexicanus 79.59 0.00e+00 1389.00
IUUC-Bta-012978 Bos taurus 96.48 0.00e+00 1631.00
IUUC-Cja-019081 Callithrix jacchus 97.21 0.00e+00 1639.00
IUUC-Cfa-020736 Canis familiaris 94.39 0.00e+00 1540.00
IUUC-Cpo-021581 Cavia porcellus 96.23 0.00e+00 1625.00
IUUC-Csa-024189 Chlorocebus sabaeus 95.82 0.00e+00 923.00
IUUC-Cho-024751 Choloepus hoffmanni 95.50 0.00e+00 1545.00
IUUC-Cin-025773 Ciona intestinalis 42.19 2.00e-148 519.00
IUUC-Csv-026090 Ciona savignyi 39.19 3.00e-173 602.00
IUUC-Dre-027788 Danio rerio 79.95 0.00e+00 1390.00
IUUC-Dno-030022 Dasypus novemcinctus 96.35 0.00e+00 1625.00
IUUC-Dme-031577 Drosophila melanogaster 47.68 0.00e+00 733.00
IUUC-Ete-032402 Echinops telfairi 94.02 0.00e+00 1543.00
IUUC-Eca-033908 Equus caballus 97.57 0.00e+00 1644.00
IUUC-Eeu-034869 Erinaceus europaeus 96.98 0.00e+00 917.00
IUUC-Fca-036023 Felis catus 97.08 0.00e+00 1636.00
IUUC-Fal-037477 Ficedula albicollis 91.13 0.00e+00 1528.00
IUUC-Gmo-039197 Gadus morhua 80.32 0.00e+00 1372.00
IUUC-Gga-040704 Gallus gallus 91.25 0.00e+00 1524.00
IUUC-Gac-041511 Gasterosteus aculeatus 79.22 0.00e+00 1378.00
IUUC-Ggo-044527 Gorilla gorilla 93.81 0.00e+00 1564.00
IUUC-Hsa-046082 Homo sapiens 97.21 0.00e+00 1642.00
IUUC-Itr-048168 Ictidomys tridecemlineatus 96.96 0.00e+00 1635.00
IUUC-Lch-049772 Latimeria chalumnae 77.16 0.00e+00 1251.00
IUUC-Loc-052541 Lepisosteus oculatus 81.70 0.00e+00 1401.00
IUUC-Laf-053852 Loxodonta africana 96.23 0.00e+00 1621.00
IUUC-Mcc-054759 Macaca mulatta 96.30 0.00e+00 836.00
IUUC-Meu-056247 Macropus eugenii 77.52 0.00e+00 836.00
IUUC-Mga-060161 Meleagris gallopavo 90.41 0.00e+00 1504.00
IUUC-Mmr-061447 Microcebus murinus 97.33 0.00e+00 1641.00
IUUC-Mdo-062110 Monodelphis domestica 93.80 0.00e+00 1533.00
IUUC-Mpu-065824 Mustela putorius furo 96.60 0.00e+00 1622.00
IUUC-Mlu-067729 Myotis lucifugus 96.84 0.00e+00 1603.00
IUUC-Nle-069721 Nomascus leucogenys 96.72 0.00e+00 1620.00
IUUC-Opr-070189 Ochotona princeps 96.94 0.00e+00 1624.00
IUUC-Ont-072122 Oreochromis niloticus 80.92 0.00e+00 1375.00
IUUC-Oan-072700 Ornithorhynchus anatinus 83.62 0.00e+00 1219.00
IUUC-Ocu-074057 Oryctolagus cuniculus 96.84 0.00e+00 1635.00
IUUC-Ola-087492 Oryzias latipes 78.98 0.00e+00 1377.00
IUUC-Oga-088084 Otolemur garnettii 97.33 0.00e+00 1634.00
IUUC-Oar-090354 Ovis aries 96.56 0.00e+00 1609.00
IUUC-Ptr-091456 Pan troglodytes 96.96 0.00e+00 1636.00
IUUC-Pan-092596 Papio anubis 95.75 0.00e+00 1608.00
IUUC-Psi-092942 Pelodiscus sinensis 91.62 0.00e+00 1523.00
IUUC-Pma-094662 Petromyzon marinus 60.72 0.00e+00 753.00
IUUC-Pfo-096838 Poecilia formosa 80.32 0.00e+00 1353.00
IUUC-Pab-097849 Pongo abelii 96.72 0.00e+00 1635.00
IUUC-Pca-100498 Procavia capensis 95.39 0.00e+00 941.00
IUUC-Pva-102599 Pteropus vampyrus 96.84 0.00e+00 1612.00
IUUC-Rno-105776 Rattus norvegicus 97.81 0.00e+00 1638.00
IUUC-Sha-106699 Sarcophilus harrisii 93.92 0.00e+00 1538.00
IUUC-Sar-113621 Sorex araneus 95.57 0.00e+00 1585.00
IUUC-Ssc-115742 Sus scrofa 96.96 0.00e+00 1637.00
IUUC-Tgu-116490 Taeniopygia guttata 90.89 0.00e+00 1528.00
IUUC-Tru-117679 Takifugu rubripes 79.83 0.00e+00 1363.00
IUUC-Tsy-119607 Tarsius syrichta 92.90 0.00e+00 1133.00
IUUC-Tni-120376 Tetraodon nigroviridis 76.54 0.00e+00 1286.00
IUUC-Tbe-127348 Tupaia belangeri 66.06 0.00e+00 637.00
IUUC-Ttr-128786 Tursiops truncatus 93.32 0.00e+00 1565.00
IUUC-Vpa-130180 Vicugna pacos 96.24 0.00e+00 1300.00
IUUC-Xtr-132631 Xenopus tropicalis 67.88 0.00e+00 1142.00
Created Date 25-Jun-2017

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