iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072700

UUCD1 version

UUC-OrA-00131

Ensembl Protein ID

ENSOANP00000004179.1

UniProt Accession

F6SL98; F6SL98_ORNAN

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000002627.2	ENSOANT00000004180.2	ENSOANP00000004179.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.90e-102	342.0	407	744

Active Site

Position(s)	Description	Evidence
712	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 407  SDWSKNFEVIFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPSH--LRLKVYEFAGRLVGKCLYESslgga 493
           7999**************************************888999***********964..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k+ eL+ gG+++pVtneNk 
   Q: 494  ykQLVRARFTRSFLAQMIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEIELVFAEEKYNRSGQLDKVIELMAGGAQTPVTNENKI 579
           99***********************************99****99...9****9*****999*************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne+ip++ll++F+e+elell+cG+ +i+v+d+k ++    g ++ ++++++wFw v+++f++e
   Q: 580  FYLNLLAQYRLASQVKEEVEHFLKGLNELIPENLLAIFDENELELLMCGTGDISVSDFKTHAvVVGGSWHFREKVMRWFWTVVSSFTQE 668
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 669  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 744
           ************************99555555.**************************************9***97 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

RRQLFYKNGQ PFPAQRHVGL RVHISHVELA VDIPVTQEVL QEPNSNVIKV AFTVRKAGRY 60
EISVKLGGLN VAYSPYHKVF QPGMVVPSKT KIVCHFSTLV LTIGQQHTLQ IVPRDEYDNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTGCGC CCGTCAGGGG AGCACCCGTC CTCCGGACGA GTCCTGACGA GCGCCTCTCC 60
TTTTCTTCCC CTCCCGCCGG CAGTTGTTCT ATAAGAACGG GCAGCCCTTC CCCGCTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	84.56	0.00e+00	1249.00
IUUC-Apl-004071	Anas platyrhynchos	82.55	0.00e+00	1192.00
IUUC-Aca-005218	Anolis carolinensis	83.78	0.00e+00	1209.00
IUUC-Ame-011871	Astyanax mexicanus	73.69	0.00e+00	1123.00
IUUC-Bta-012978	Bos taurus	83.76	0.00e+00	1238.00
IUUC-Cja-019081	Callithrix jacchus	84.30	0.00e+00	1250.00
IUUC-Cfa-020736	Canis familiaris	82.04	0.00e+00	1198.00
IUUC-Cpo-021581	Cavia porcellus	84.16	0.00e+00	1246.00
IUUC-Csa-024189	Chlorocebus sabaeus	73.07	1.00e-153	535.00
IUUC-Cho-024751	Choloepus hoffmanni	82.95	0.00e+00	1187.00
IUUC-Cin-025773	Ciona intestinalis	39.52	7.00e-133	467.00
IUUC-Csv-026090	Ciona savignyi	38.18	1.00e-142	499.00
IUUC-Dre-027788	Danio rerio	73.32	0.00e+00	1120.00
IUUC-Dno-030022	Dasypus novemcinctus	84.03	0.00e+00	1241.00
IUUC-Dme-031577	Drosophila melanogaster	44.39	6.00e-176	610.00
IUUC-Ete-032402	Echinops telfairi	81.90	0.00e+00	1171.00
IUUC-Eca-033908	Equus caballus	84.83	0.00e+00	1251.00
IUUC-Eeu-034869	Erinaceus europaeus	91.79	0.00e+00	868.00
IUUC-Fca-036023	Felis catus	84.56	0.00e+00	1248.00
IUUC-Fal-037477	Ficedula albicollis	83.09	0.00e+00	1217.00
IUUC-Gmo-039197	Gadus morhua	73.15	0.00e+00	1102.00
IUUC-Gga-040704	Gallus gallus	83.36	0.00e+00	1211.00
IUUC-Gac-041511	Gasterosteus aculeatus	72.10	0.00e+00	1107.00
IUUC-Ggo-044527	Gorilla gorilla	80.83	0.00e+00	1179.00
IUUC-Hsa-046082	Homo sapiens	84.43	0.00e+00	1253.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	84.30	0.00e+00	1246.00
IUUC-Lch-049772	Latimeria chalumnae	68.86	0.00e+00	984.00
IUUC-Loc-052541	Lepisosteus oculatus	75.53	0.00e+00	1142.00
IUUC-Laf-053852	Loxodonta africana	84.03	0.00e+00	1238.00
IUUC-Mcc-054759	Macaca mulatta	71.83	7.00e-131	459.00
IUUC-Meu-056247	Macropus eugenii	68.73	6.00e-176	610.00
IUUC-Mga-060161	Meleagris gallopavo	83.22	0.00e+00	1199.00
IUUC-Mmr-061447	Microcebus murinus	84.56	0.00e+00	1249.00
IUUC-Mdo-062110	Monodelphis domestica	84.83	0.00e+00	1233.00
IUUC-Mmu-064349	Mus musculus	83.62	0.00e+00	1239.00
IUUC-Mpu-065824	Mustela putorius furo	84.56	0.00e+00	1246.00
IUUC-Mlu-067729	Myotis lucifugus	84.30	0.00e+00	1224.00
IUUC-Nle-069721	Nomascus leucogenys	84.30	0.00e+00	1244.00
IUUC-Opr-070189	Ochotona princeps	84.16	0.00e+00	1244.00
IUUC-Ont-072122	Oreochromis niloticus	73.02	0.00e+00	1095.00
IUUC-Ocu-074057	Oryctolagus cuniculus	84.30	0.00e+00	1244.00
IUUC-Ola-087492	Oryzias latipes	72.08	0.00e+00	1111.00
IUUC-Oga-088084	Otolemur garnettii	84.43	0.00e+00	1241.00
IUUC-Oar-090354	Ovis aries	83.83	0.00e+00	1217.00
IUUC-Ptr-091456	Pan troglodytes	84.30	0.00e+00	1249.00
IUUC-Pan-092596	Papio anubis	82.84	0.00e+00	1219.00
IUUC-Psi-092942	Pelodiscus sinensis	83.76	0.00e+00	1219.00
IUUC-Pma-094662	Petromyzon marinus	60.36	0.00e+00	687.00
IUUC-Pfo-096838	Poecilia formosa	73.03	0.00e+00	1085.00
IUUC-Pab-097849	Pongo abelii	84.30	0.00e+00	1252.00
IUUC-Pca-100498	Procavia capensis	73.87	3.00e-159	555.00
IUUC-Pva-102599	Pteropus vampyrus	84.30	0.00e+00	1234.00
IUUC-Rno-105776	Rattus norvegicus	84.16	0.00e+00	1240.00
IUUC-Sha-106699	Sarcophilus harrisii	84.97	0.00e+00	1238.00
IUUC-Sar-113621	Sorex araneus	83.49	0.00e+00	1224.00
IUUC-Ssc-115742	Sus scrofa	84.30	0.00e+00	1244.00
IUUC-Tgu-116490	Taeniopygia guttata	82.82	0.00e+00	1217.00
IUUC-Tru-117679	Takifugu rubripes	72.75	0.00e+00	1092.00
IUUC-Tsy-119607	Tarsius syrichta	87.00	0.00e+00	941.00
IUUC-Tni-120376	Tetraodon nigroviridis	69.69	0.00e+00	1015.00
IUUC-Tbe-127348	Tupaia belangeri	65.14	9.00e-177	612.00
IUUC-Ttr-128786	Tursiops truncatus	83.09	0.00e+00	1214.00
IUUC-Vpa-130180	Vicugna pacos	80.78	0.00e+00	930.00
IUUC-Xtr-132631	Xenopus tropicalis	62.66	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence