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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063394
UUCD1 version UUC-MuM-00526
Ensembl Protein ID ENSMUSP00000040229.7
UniProt Accession Q6PDK8; Q6IS30; Q8BID3; DTX4_MOUSE
Genbank Protein ID AAH58647.1; AAH69975.1; BAC39704.1
Protein Name E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING-type E3 ubiquitin transferase DTX4
Genbank Nucleotide ID BC058647; BC069975; AK086624
Gene Name Dtx4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039982.7 ENSMUST00000045521.7 ENSMUSP00000040229.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.40e-07 31.2 406 465
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..........kdgpl........vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                       + +CgH++h  Cl ++ + + ++ ++ +CP+C+
   Q: 406  CTICMERLtapsgykgpqP---TvkpdlvgkLSRCGHIYHIYCLVAM-YNNGNKDGSLQCPTCK 465
           9*******55555444320...222333333577**********555.56677**********6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
 Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
Protein Sequence
(Fasta)
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 60
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQYAYEKQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063394|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGAGAGAG AGAGAGAGAG AGAGAGAGAG AGAGAGAGAG AGAGAGAGAA TGCGTATGCA 60
TGCACGAGCT GTAGGGAGAT GCGAGCCTCT GAGCTCACGC CGCGGACACG GCCGGTGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063394|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50918--WWE
PS50089--ZF_RING_2
Pfam

PF02825--WWE
PF00097--zf-C3HC4
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
KEGG mmu:207521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001420 Ailuropoda melanoleuca 88.91 0.00e+00 919.00
IUUC-Apl-004196 Anas platyrhynchos 65.40 0.00e+00 666.00
IUUC-Aca-004282 Anolis carolinensis 82.31 0.00e+00 971.00
IUUC-Aly-006456 Arabidopsis lyrata 35.38 1.00e-06 47.40
IUUC-Bta-013541 Bos taurus 89.88 1.00e-167 583.00
IUUC-Cja-019164 Callithrix jacchus 93.05 0.00e+00 1005.00
IUUC-Cfa-020475 Canis familiaris 90.14 0.00e+00 946.00
IUUC-Cpo-021358 Cavia porcellus 91.09 0.00e+00 1041.00
IUUC-Csa-023895 Chlorocebus sabaeus 94.35 0.00e+00 1085.00
IUUC-Cho-024781 Choloepus hoffmanni 98.05 1.00e-170 592.00
IUUC-Cin-025512 Ciona intestinalis 52.73 4.00e-65 242.00
IUUC-Csv-026089 Ciona savignyi 52.04 3.00e-63 236.00
IUUC-Dre-028695 Danio rerio 82.07 3.00e-164 572.00
IUUC-Dno-029115 Dasypus novemcinctus 92.41 0.00e+00 1048.00
IUUC-Dor-030701 Dipodomys ordii 87.70 0.00e+00 769.00
IUUC-Dme-031724 Drosophila melanogaster 41.63 8.00e-49 188.00
IUUC-Eca-033784 Equus caballus 96.04 0.00e+00 681.00
IUUC-Eeu-035106 Erinaceus europaeus 74.88 0.00e+00 753.00
IUUC-Fca-035528 Felis catus 92.02 0.00e+00 1038.00
IUUC-Fal-037476 Ficedula albicollis 90.88 4.00e-174 604.00
IUUC-Gmo-039590 Gadus morhua 82.86 2.00e-145 509.00
IUUC-Gga-040618 Gallus gallus 80.94 0.00e+00 931.00
IUUC-Gac-041759 Gasterosteus aculeatus 67.90 0.00e+00 802.00
IUUC-Ggo-044787 Gorilla gorilla 94.18 0.00e+00 1083.00
IUUC-Hsa-045998 Homo sapiens 93.86 0.00e+00 1088.00
IUUC-Itr-048056 Ictidomys tridecemlineatus 94.27 0.00e+00 1049.00
IUUC-Lch-049663 Latimeria chalumnae 61.40 0.00e+00 677.00
IUUC-Laf-054482 Loxodonta africana 91.76 0.00e+00 1061.00
IUUC-Mcc-055090 Macaca mulatta 93.36 0.00e+00 957.00
IUUC-Meu-056882 Macropus eugenii 83.91 5.00e-168 584.00
IUUC-Mga-060182 Meleagris gallopavo 71.32 0.00e+00 691.00
IUUC-Mdo-062755 Monodelphis domestica 84.67 0.00e+00 800.00
IUUC-Mac-064552 Musa acuminata 30.65 3.00e-04 40.00
IUUC-Mpu-066276 Mustela putorius furo 93.70 0.00e+00 1063.00
IUUC-Mlu-067664 Myotis lucifugus 87.90 0.00e+00 647.00
IUUC-Nle-069360 Nomascus leucogenys 94.18 0.00e+00 1064.00
IUUC-Opr-070345 Ochotona princeps 84.24 0.00e+00 737.00
IUUC-Ont-072400 Oreochromis niloticus 62.18 0.00e+00 772.00
IUUC-Oan-073373 Ornithorhynchus anatinus 92.57 7.00e-169 586.00
IUUC-Ocu-074185 Oryctolagus cuniculus 92.40 0.00e+00 834.00
IUUC-Ola-086644 Oryzias latipes 80.90 2.00e-154 539.00
IUUC-Oga-088147 Otolemur garnettii 94.66 0.00e+00 1034.00
IUUC-Oar-090311 Ovis aries 95.55 0.00e+00 639.00
IUUC-Ptr-091535 Pan troglodytes 93.86 0.00e+00 1086.00
IUUC-Pan-092233 Papio anubis 94.02 0.00e+00 1084.00
IUUC-Psi-093689 Pelodiscus sinensis 81.21 0.00e+00 852.00
IUUC-Pfo-096557 Poecilia formosa 66.40 0.00e+00 773.00
IUUC-Pab-098027 Pongo abelii 94.67 0.00e+00 1090.00
IUUC-Pca-100457 Procavia capensis 99.13 8.00e-125 440.00
IUUC-Pva-102381 Pteropus vampyrus 81.09 0.00e+00 691.00
IUUC-Rno-105599 Rattus norvegicus 96.88 0.00e+00 904.00
IUUC-Ssc-116338 Sus scrofa 92.10 0.00e+00 1060.00
IUUC-Tgu-116484 Taeniopygia guttata 90.55 3.00e-162 564.00
IUUC-Tru-118590 Takifugu rubripes 82.87 2.00e-156 545.00
IUUC-Tsy-119110 Tarsius syrichta 92.59 0.00e+00 780.00
IUUC-Tni-120695 Tetraodon nigroviridis 68.25 0.00e+00 783.00
IUUC-Tbe-127393 Tupaia belangeri 85.22 0.00e+00 839.00
IUUC-Ttr-128524 Tursiops truncatus 78.88 0.00e+00 699.00
IUUC-Vpa-130723 Vicugna pacos 97.20 2.00e-60 226.00
Created Date 25-Jun-2017

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