iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027456

Ensembl Protein ID

ENSDARP00000056829.4

UniProt Accession

Q4V920; PACN1_DANRE

Genbank Protein ID

AAH97107.1

Protein Name

Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1

Genbank Nucleotide ID

CU694224

Gene Name

pacsin1b; pacsin1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000042128.7	ENSDART00000056830.5	ENSDARP00000056829.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-16	60.3	390	445

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lydye+q++deLt+k+Gd ++ + ++e ++gW+kg + ++g+ Gl P+n+ve +
   Q: 390  RVRALYDYEGQEQDELTFKAGDELTKL-EDEDEQGWCKG-RLDSGQLGLYPANYVEPV 445
           699************************.9**********.59*************976 PP

Organism

Danio rerio

Functional Description
(View)

Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain and heart development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior.

Protein Sequence
(Fasta)

MSGAYDESAM SDETTDSFWE VGNYKRTVKR IEDGHRLCND MMSCIQERAK IEKAYSQQLT 60
DWSKRWRQLV ERGPQYGTLE RAWLAVMTEA EKVSELHQEV KNNLLNEDLE KVKNWQKDAY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCAGGATC GTCATATCAC AGAGAAGCTG GATTCACGTT CATCTCTGTT TGGTATGTGT 60
TAACGCTTGA TTTTGCTCTT ATTCTGCTGT TGAAATGTAA TGTCCTGTCG ATAAACAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome

Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028518--PACSIN1
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0043005--C:neuron projection
GO:0032587--C:ruffle membrane
GO:0045202--C:synapse
GO:0008289--F:lipid binding
GO:0007015--P:actin filament organization
GO:0060088--P:auditory receptor cell stereocilium organization
GO:0006897--P:endocytosis
GO:0048812--P:neuron projection morphogenesis
GO:0097320--P:plasma membrane tubulation
GO:0030100--P:regulation of endocytosis

KEGG

dre:619246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001861	Ailuropoda melanoleuca	68.02	2.00e-167	582.00
IUUC-Apl-003667	Anas platyrhynchos	74.94	2.00e-179	622.00
IUUC-Ame-011410	Astyanax mexicanus	85.01	0.00e+00	719.00
IUUC-Bta-013509	Bos taurus	74.72	2.00e-171	595.00
IUUC-Cel-018168	Caenorhabditis elegans	29.63	8.00e-59	221.00
IUUC-Cja-019659	Callithrix jacchus	75.62	0.00e+00	639.00
IUUC-Cfa-020396	Canis familiaris	74.94	1.00e-176	612.00
IUUC-Cpo-022376	Cavia porcellus	75.39	4.00e-178	617.00
IUUC-Csa-023701	Chlorocebus sabaeus	75.62	5.00e-178	617.00
IUUC-Cin-025707	Ciona intestinalis	44.82	4.00e-102	364.00
IUUC-Csv-026244	Ciona savignyi	46.15	1.00e-51	196.00
IUUC-Dor-030122	Dipodomys ordii	60.28	2.00e-155	542.00
IUUC-Eca-033679	Equus caballus	69.78	2.00e-156	545.00
IUUC-Fca-036314	Felis catus	74.94	6.00e-177	613.00
IUUC-Fal-037300	Ficedula albicollis	74.83	0.00e+00	647.00
IUUC-Gga-040626	Gallus gallus	75.06	9.00e-176	609.00
IUUC-Gac-041445	Gasterosteus aculeatus	78.89	0.00e+00	654.00
IUUC-Ggo-045557	Gorilla gorilla	75.62	1.00e-177	615.00
IUUC-Hsa-045778	Homo sapiens	75.62	1.00e-177	615.00
IUUC-Itr-048856	Ictidomys tridecemlineatus	75.17	3.00e-177	614.00
IUUC-Lch-050070	Latimeria chalumnae	67.81	0.00e+00	634.00
IUUC-Loc-051764	Lepisosteus oculatus	80.85	0.00e+00	701.00
IUUC-Laf-054465	Loxodonta africana	74.11	1.00e-178	619.00
IUUC-Mcc-055324	Macaca mulatta	75.62	3.00e-178	617.00
IUUC-Meu-056348	Macropus eugenii	76.06	5.00e-180	623.00
IUUC-Mga-059285	Meleagris gallopavo	75.52	9.00e-173	599.00
IUUC-Mmr-061367	Microcebus murinus	74.22	3.00e-171	594.00
IUUC-Mmu-064347	Mus musculus	74.22	0.00e+00	640.00
IUUC-Mpu-066864	Mustela putorius furo	75.17	4.00e-177	614.00
IUUC-Nle-070027	Nomascus leucogenys	75.88	8.00e-169	586.00
IUUC-Ont-072188	Oreochromis niloticus	78.62	0.00e+00	699.00
IUUC-Ocu-074297	Oryctolagus cuniculus	74.27	2.00e-171	595.00
IUUC-Ola-087188	Oryzias latipes	75.28	4.00e-171	594.00
IUUC-Oga-088856	Otolemur garnettii	74.94	1.00e-173	602.00
IUUC-Pan-092056	Papio anubis	75.62	5.00e-178	617.00
IUUC-Pfo-097281	Poecilia formosa	73.94	0.00e+00	654.00
IUUC-Pab-098202	Pongo abelii	75.39	3.00e-177	614.00
IUUC-Pca-100881	Procavia capensis	74.50	3.00e-175	608.00
IUUC-Pva-102181	Pteropus vampyrus	75.62	3.00e-178	618.00
IUUC-Rno-105295	Rattus norvegicus	72.20	2.00e-174	604.00
IUUC-Sar-113461	Sorex araneus	56.56	4.00e-140	491.00
IUUC-Ssc-115685	Sus scrofa	73.60	2.00e-173	602.00
IUUC-Tgu-116524	Taeniopygia guttata	69.93	1.00e-167	582.00
IUUC-Tsy-118901	Tarsius syrichta	54.49	3.00e-91	328.00
IUUC-Ttr-129069	Tursiops truncatus	74.41	4.00e-166	577.00
IUUC-Xtr-132759	Xenopus tropicalis	70.53	0.00e+00	632.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence