iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000014517.11	ENSDART00000148666.2	ENSDARP00000124239.1
ENSDARG00000014517.11	ENSDART00000029121.7	ENSDARP00000036699.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-58	198.9	324	850
UBD/Alpha-Helix/UBA	5.70e-19	68.5	721	758

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
813	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.......wkskkk................ 66
           tG+kNlgN+CY+NSv+Q+L+ ip+++  + + +  k+ +e+p++p++++ ++++kl   l                             
   Q: 324  TGMKNLGNSCYLNSVMQVLFTIPDFQTKYVS-NIDKIFDEAPSDPTQDFKTQVAKLGYGLlsgeyskP----Apdpadepntsaeprgd 407
           7*****************************9.888888999*******************44444440....15555555555666666 PP
   S: 67   ..avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq 153
              ++pr++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++    s+ F++ ++++
   Q: 408  qvGIAPRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGMNPSEAFRFLVEEK 467
           66*****************************************.............................456667899******** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkq 215
           i+c++ ++ + ++   + ++lpvp+++ t++                             +  cL++ +++e+l++   ++++  ++k+
   Q: 468  IVCQQSQKAKYTQRVDYIVQLPVPMDQATNMDelqeaerrreeaessgapppvapraqiPFAACLAALSEPETLTD---FWSSAVQAKT 553
           ***************************998879******************************************7...********** PP
   S: 216  eaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts..................................... 267
           +a+k++++ ++P+ L++++k+f+f  + ++++k++ ++++p++Ldl+   +                                      
   Q: 554  TATKTTRFASFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPETLDLNALRAMgqqpgeellpevappplmtpdvevkgilgshgneedd 641
           ************************997.*******************866665566666666666666666666666666666666666 PP
   S: 268  ....................................................peekqke.............................. 274
                                                               +     +                              
   Q: 642  slyspllspvlddstvsqlcemgfpleacrkavyytgntgidaamnwvmghmD-----Dpdfaaplvlpgsssapgttpteslpeehla 725
           66666666666555555555555555555555555555555555555555550.....0555555555555555555555566666666 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kYeL+a ++H+G s+ +GHY
   Q: 726  tivsmgfsrdqatralratnnvleravdwifshlddlesmdvseggrseggseasrepppgprvrdgTGKYELFAFISHMGsSTMCGHY 814
           6666666666677777777777777777777777777777788888888888888999999999999********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +++W+ f+D+kV ++  e+  +   + +Y++fY+r
   Q: 815  VCHIKK-DQQWVIFNDQKVCAS--EKPPK---DLGYLYFYRR 850
           ******.999*********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ l+ +v+MGF+r++a +aLra+nn le+Av++++++
   Q: 721  EEHLATIVSMGFSRDQATRALRATNNVLERAVDWIFSH 758
           67899*******************************97 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MTEVSEILMS VLSAIRVPRP GDRVHKDECA FSFSSPESEG GLYVCMNSFL GFGSKYVDRH 60
HAKTGQRAYL HITRTRKTQK EDDPNSGSGD PPKKKPTRLA IGIEGGFDVE QEQYEEEVKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCCCCTG GCCTCGAATG AACACACTGG ATCATCAGCA GCAGCTTTTC ATTGAGGGGA 60
ATCGCAGAAA CAAGGGGGCT GTCAGAGACT TCAGGAGCGG GGGCCAAAGA AAACCCAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	68.00	0.00e+00	1148.00
IUUC-Apl-003774	Anas platyrhynchos	67.88	0.00e+00	1123.00
IUUC-Aca-005368	Anolis carolinensis	65.77	0.00e+00	1147.00
IUUC-Ath-006974	Arabidopsis thaliana	44.76	0.00e+00	667.00
IUUC-Acl-008057	Aspergillus clavatus	34.04	2.00e-118	419.00
IUUC-Afl-008547	Aspergillus flavus	35.62	2.00e-107	383.00
IUUC-Afu-008805	Aspergillus fumigatus	32.39	2.00e-103	370.00
IUUC-Ang-009720	Aspergillus niger	32.75	8.00e-107	381.00
IUUC-Aor-010111	Aspergillus oryzae	33.68	5.00e-114	405.00
IUUC-Ate-010531	Aspergillus terreus	31.55	2.00e-96	347.00
IUUC-Ame-011893	Astyanax mexicanus	89.62	0.00e+00	1298.00
IUUC-Bgr-012183	Blumeria graminis	31.97	1.00e-108	387.00
IUUC-Bta-013179	Bos taurus	68.39	0.00e+00	1158.00
IUUC-Bci-013858	Botrytis cinerea	34.11	1.00e-118	420.00
IUUC-Cel-018625	Caenorhabditis elegans	32.57	2.00e-118	419.00
IUUC-Cja-019063	Callithrix jacchus	67.10	0.00e+00	1137.00
IUUC-Cfa-020976	Canis familiaris	67.53	0.00e+00	1134.00
IUUC-Cpo-022265	Cavia porcellus	67.30	0.00e+00	1137.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.91	1.00e-108	387.00
IUUC-Csa-024177	Chlorocebus sabaeus	64.59	0.00e+00	1021.00
IUUC-Cho-024702	Choloepus hoffmanni	63.59	0.00e+00	686.00
IUUC-Cin-025411	Ciona intestinalis	48.10	0.00e+00	773.00
IUUC-Csv-026347	Ciona savignyi	45.71	0.00e+00	752.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.75	1.00e-99	357.00
IUUC-Dno-029034	Dasypus novemcinctus	68.74	0.00e+00	1164.00
IUUC-Dse-031467	Dothistroma septosporum	33.88	1.00e-115	410.00
IUUC-Dme-032075	Drosophila melanogaster	47.23	0.00e+00	745.00
IUUC-Ete-032865	Echinops telfairi	61.55	0.00e+00	1016.00
IUUC-Eca-034059	Equus caballus	68.11	0.00e+00	1155.00
IUUC-Eeu-035304	Erinaceus europaeus	64.63	0.00e+00	1051.00
IUUC-Fca-035515	Felis catus	68.39	0.00e+00	1156.00
IUUC-Fal-037271	Ficedula albicollis	66.46	0.00e+00	1072.00
IUUC-Fox-037745	Fusarium oxysporum	33.57	4.00e-116	412.00
IUUC-Fso-038158	Fusarium solani	34.16	8.00e-117	414.00
IUUC-Gmo-039071	Gadus morhua	85.35	0.00e+00	1354.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.67	2.00e-111	396.00
IUUC-Gga-040635	Gallus gallus	68.21	0.00e+00	1190.00
IUUC-Gac-042528	Gasterosteus aculeatus	85.25	0.00e+00	1354.00
IUUC-Gma-043614	Glycine max	43.19	0.00e+00	651.00
IUUC-Ggo-044602	Gorilla gorilla	68.39	0.00e+00	1158.00
IUUC-Hsa-045959	Homo sapiens	68.39	0.00e+00	1158.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	68.11	0.00e+00	1154.00
IUUC-Lch-049648	Latimeria chalumnae	68.24	0.00e+00	1131.00
IUUC-Lpe-051523	Leersia perrieri	43.04	0.00e+00	637.00
IUUC-Loc-052520	Lepisosteus oculatus	71.12	0.00e+00	1133.00
IUUC-Lma-053216	Leptosphaeria maculans	34.28	2.00e-103	371.00
IUUC-Laf-054327	Loxodonta africana	68.27	0.00e+00	1149.00
IUUC-Mcc-055443	Macaca mulatta	68.51	0.00e+00	1161.00
IUUC-Meu-056298	Macropus eugenii	68.63	0.00e+00	796.00
IUUC-Mor-057106	Magnaporthe oryzae	34.92	2.00e-120	427.00
IUUC-Mpo-057589	Magnaporthe poae	33.72	3.00e-116	412.00
IUUC-Mtr-058680	Medicago truncatula	45.40	0.00e+00	684.00
IUUC-Mla-058903	Melampsora laricipopulina	33.11	4.00e-111	395.00
IUUC-Mga-059669	Meleagris gallopavo	67.59	0.00e+00	1119.00
IUUC-Mvi-060476	Microbotryum violaceum	34.89	3.00e-113	403.00
IUUC-Mmr-060575	Microcebus murinus	68.16	0.00e+00	1155.00
IUUC-Mdo-062183	Monodelphis domestica	67.73	0.00e+00	1121.00
IUUC-Mmu-063592	Mus musculus	68.31	0.00e+00	1158.00
IUUC-Mpu-066082	Mustela putorius furo	67.06	0.00e+00	1129.00
IUUC-Mlu-067345	Myotis lucifugus	67.21	0.00e+00	1142.00
IUUC-Nfi-068558	Neosartorya fischeri	34.16	4.00e-115	409.00
IUUC-Ncr-068960	Neurospora crassa	33.14	1.00e-106	381.00
IUUC-Nle-070173	Nomascus leucogenys	67.41	0.00e+00	1135.00
IUUC-Opr-070556	Ochotona princeps	69.13	0.00e+00	1175.00
IUUC-Ont-071502	Oreochromis niloticus	87.81	0.00e+00	1373.00
IUUC-Ocu-074861	Oryctolagus cuniculus	67.53	0.00e+00	1138.00
IUUC-Ola-086951	Oryzias latipes	88.10	0.00e+00	1349.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.63	2.00e-165	576.00
IUUC-Oga-088625	Otolemur garnettii	67.37	0.00e+00	1145.00
IUUC-Oar-089995	Ovis aries	67.92	0.00e+00	1139.00
IUUC-Ptr-090640	Pan troglodytes	67.33	0.00e+00	1154.00
IUUC-Pan-091974	Papio anubis	67.80	0.00e+00	1151.00
IUUC-Psi-093957	Pelodiscus sinensis	67.79	0.00e+00	1180.00
IUUC-Pma-094242	Petromyzon marinus	69.29	3.00e-153	534.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.29	4.00e-97	349.00
IUUC-Ppa-095901	Physcomitrella patens	46.24	0.00e+00	714.00
IUUC-Pfo-097148	Poecilia formosa	86.87	0.00e+00	1357.00
IUUC-Pab-098068	Pongo abelii	63.50	0.00e+00	1017.00
IUUC-Pop-098943	Populus trichocarpa	45.62	0.00e+00	678.00
IUUC-Pca-100738	Procavia capensis	69.37	0.00e+00	816.00
IUUC-Ppe-101315	Prunus persica	45.17	0.00e+00	660.00
IUUC-Pva-102154	Pteropus vampyrus	68.16	0.00e+00	1148.00
IUUC-Pgr-103343	Puccinia graminis	34.17	3.00e-100	359.00
IUUC-Ptt-103928	Puccinia triticina	30.50	6.00e-98	352.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.26	6.00e-100	358.00
IUUC-Rno-105801	Rattus norvegicus	68.31	0.00e+00	1157.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.32	2.00e-60	228.00
IUUC-Sha-107635	Sarcophilus harrisii	67.38	0.00e+00	1126.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	30.47	3.00e-92	333.00
IUUC-Smo-108848	Selaginella moellendorffii	46.04	0.00e+00	665.00
IUUC-Sit-110728	Setaria italica	44.81	0.00e+00	699.00
IUUC-Sbi-114419	Sorghum bicolor	44.22	0.00e+00	683.00
IUUC-Sre-115225	Sporisorium reilianum	32.93	2.00e-106	380.00
IUUC-Ssc-115686	Sus scrofa	67.37	0.00e+00	1148.00
IUUC-Tgu-117346	Taeniopygia guttata	67.67	0.00e+00	1168.00
IUUC-Tru-118350	Takifugu rubripes	83.64	0.00e+00	1375.00
IUUC-Tni-120658	Tetraodon nigroviridis	85.78	0.00e+00	1365.00
IUUC-Tca-121585	Theobroma cacao	44.56	0.00e+00	659.00
IUUC-Tre-122043	Trichoderma reesei	32.41	2.00e-103	370.00
IUUC-Tvi-122303	Trichoderma virens	32.48	1.00e-105	377.00
IUUC-Tme-126909	Tuber melanosporum	33.84	1.00e-105	377.00
IUUC-Tbe-127261	Tupaia belangeri	63.25	0.00e+00	722.00
IUUC-Uma-129599	Ustilago maydis	33.92	7.00e-114	405.00
IUUC-Vda-129688	Verticillium dahliae	33.22	2.00e-108	386.00
IUUC-Vvi-131116	Vitis vinifera	44.10	0.00e+00	653.00
IUUC-Xtr-131953	Xenopus tropicalis	67.21	0.00e+00	1098.00
IUUC-Xma-133837	Xiphophorus maculatus	86.87	0.00e+00	1357.00
IUUC-Yli-134510	Yarrowia lipolytica	34.67	6.00e-114	405.00
IUUC-Zma-135786	Zea mays	43.41	0.00e+00	652.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence