iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000023126.2	ENSPANT00000008668.2	ENSPANP00000018770.1
ENSPANG00000023126.2	ENSPANT00000019076.1	ENSPANP00000018767.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-127	425.3	420	755

Active Site

Position(s)	Description	Evidence
724	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 681  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 755
           ******************************99999**************************************76 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

YGNLVFNANL SNFSLFLVLC AKNLAKKDFF RLPDPFAKIV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYVG KTDSITISVW NHKKIHKKQG AGFLGCVRLL SNAISRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACGCCGC GGGGGCGCGC ACGCACGCAG GCACGGGGGC GCGCAGGGCC GGGCCGGCAC 60
GGCGGCGGGC GCGCGCGCGG CTCGGGGAGG CGGCGGCGGC GGCGGAAGCG GCGAGGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	90.17	0.00e+00	1402.00
IUUC-Apl-004155	Anas platyrhynchos	94.14	0.00e+00	1448.00
IUUC-Aca-005238	Anolis carolinensis	92.59	0.00e+00	1413.00
IUUC-Ame-010901	Astyanax mexicanus	87.70	0.00e+00	1342.00
IUUC-Bta-013221	Bos taurus	88.64	0.00e+00	1347.00
IUUC-Cja-018985	Callithrix jacchus	99.59	0.00e+00	1536.00
IUUC-Cfa-020568	Canis familiaris	97.71	0.00e+00	1491.00
IUUC-Cpo-022531	Cavia porcellus	98.92	0.00e+00	1525.00
IUUC-Csa-024145	Chlorocebus sabaeus	96.08	0.00e+00	1462.00
IUUC-Cho-024963	Choloepus hoffmanni	80.52	0.00e+00	978.00
IUUC-Cin-025126	Ciona intestinalis	61.32	0.00e+00	909.00
IUUC-Csv-026339	Ciona savignyi	61.04	0.00e+00	923.00
IUUC-Dre-028341	Danio rerio	88.39	0.00e+00	1355.00
IUUC-Dno-029705	Dasypus novemcinctus	98.12	0.00e+00	1501.00
IUUC-Dme-031740	Drosophila melanogaster	71.11	2.00e-175	609.00
IUUC-Ete-032715	Echinops telfairi	67.62	0.00e+00	1036.00
IUUC-Eca-034125	Equus caballus	98.92	0.00e+00	1525.00
IUUC-Eeu-034945	Erinaceus europaeus	69.55	0.00e+00	1018.00
IUUC-Fca-035905	Felis catus	94.27	0.00e+00	1443.00
IUUC-Fal-037336	Ficedula albicollis	93.27	0.00e+00	1409.00
IUUC-Gmo-039486	Gadus morhua	76.71	0.00e+00	858.00
IUUC-Gga-040218	Gallus gallus	94.74	0.00e+00	1446.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.79	0.00e+00	1240.00
IUUC-Ggo-045408	Gorilla gorilla	93.65	0.00e+00	1458.00
IUUC-Hsa-045878	Homo sapiens	99.73	0.00e+00	1539.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	98.11	0.00e+00	1511.00
IUUC-Lch-050026	Latimeria chalumnae	70.73	0.00e+00	1107.00
IUUC-Loc-052628	Lepisosteus oculatus	82.66	0.00e+00	1327.00
IUUC-Laf-053644	Loxodonta africana	89.99	0.00e+00	1390.00
IUUC-Mcc-055479	Macaca mulatta	88.36	0.00e+00	1313.00
IUUC-Meu-056436	Macropus eugenii	56.30	0.00e+00	814.00
IUUC-Mga-059723	Meleagris gallopavo	89.79	0.00e+00	1386.00
IUUC-Mmr-060806	Microcebus murinus	71.80	0.00e+00	1118.00
IUUC-Mdo-063005	Monodelphis domestica	94.86	0.00e+00	1451.00
IUUC-Mmu-063634	Mus musculus	94.99	0.00e+00	1432.00
IUUC-Mpu-065898	Mustela putorius furo	95.14	0.00e+00	1446.00
IUUC-Mlu-067584	Myotis lucifugus	97.61	0.00e+00	1533.00
IUUC-Nle-069033	Nomascus leucogenys	99.73	0.00e+00	1536.00
IUUC-Opr-070591	Ochotona princeps	67.66	0.00e+00	1029.00
IUUC-Ont-072265	Oreochromis niloticus	84.66	0.00e+00	1293.00
IUUC-Oan-073621	Ornithorhynchus anatinus	89.58	0.00e+00	1419.00
IUUC-Ocu-073960	Oryctolagus cuniculus	97.57	0.00e+00	1493.00
IUUC-Ola-086597	Oryzias latipes	74.67	0.00e+00	1145.00
IUUC-Oga-088579	Otolemur garnettii	99.46	0.00e+00	1533.00
IUUC-Oar-090396	Ovis aries	94.83	0.00e+00	1414.00
IUUC-Ptr-091624	Pan troglodytes	99.73	0.00e+00	1539.00
IUUC-Psi-093298	Pelodiscus sinensis	71.87	0.00e+00	1118.00
IUUC-Pma-094354	Petromyzon marinus	64.38	0.00e+00	967.00
IUUC-Pfo-097203	Poecilia formosa	81.95	0.00e+00	1254.00
IUUC-Pab-097540	Pongo abelii	99.58	0.00e+00	1466.00
IUUC-Pca-100379	Procavia capensis	73.81	0.00e+00	651.00
IUUC-Pva-102754	Pteropus vampyrus	70.60	0.00e+00	1082.00
IUUC-Rno-105396	Rattus norvegicus	95.13	0.00e+00	1435.00
IUUC-Sha-107216	Sarcophilus harrisii	94.67	0.00e+00	1467.00
IUUC-Sar-113250	Sorex araneus	96.85	0.00e+00	832.00
IUUC-Ssc-116413	Sus scrofa	94.33	0.00e+00	1415.00
IUUC-Tgu-116723	Taeniopygia guttata	93.67	0.00e+00	1422.00
IUUC-Tru-117843	Takifugu rubripes	79.79	0.00e+00	1236.00
IUUC-Tsy-119455	Tarsius syrichta	98.87	0.00e+00	1436.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.58	0.00e+00	1209.00
IUUC-Tbe-127879	Tupaia belangeri	84.96	0.00e+00	1256.00
IUUC-Ttr-128423	Tursiops truncatus	97.15	0.00e+00	1440.00
IUUC-Vpa-130591	Vicugna pacos	65.97	0.00e+00	996.00
IUUC-Xtr-132237	Xenopus tropicalis	88.38	0.00e+00	1365.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence