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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046676
Ensembl Protein ID ENSP00000248142.6
UniProt Accession Q96S15; A2IDB8; D3DU59; Q96GC7; Q9H0B7; WDR24_HUMAN
Genbank Protein ID AAK61244.1; CAB66797.1; CAM26347.1; EAW85752.1; EAW85753.1; AAH08025.1; AAH09761.2
Protein Name WD repeat-containing protein 24
Genbank Nucleotide ID AE006464; AL136863; Z92544; CH471112; CH471112; BC008025; BC009761
Gene Name WDR24; C16orf21; JFP7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000127580.15 ENST00000293883.8 ENSP00000293883.4
ENSG00000127580.15 ENST00000248142.7 ENSP00000248142.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetTRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.80e-27 94.5 336 371
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           H+++v+c+++   d + l++G++D+ +kvWD++t++
   Q: 336  HNGPVFCCDWhpEDrGWLATGGRDKMVKVWDMTTHR 371
           ***********655899****************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
Protein Sequence
(Fasta)
MGKKRTTSGE GRERQRLPAR RFRTTSPAAL RADSVDGGSL LAPLLGLTDR AFSDCPDLAD 60
GAMEKMSRVT TALGGSVLTG RTMHCHLDAP ANAISVCRDA AQVVVAGRSI FKIYAIEEEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046676|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGTAAGA AGAGGACCAC TTCCGGCGAG GGACGGGAAA GACAGCGGCT TCCGGCGCGG 60
CGGTTCCGGA CAACCGTGCG CTTTTAGTAA AAGATTGGGG TTCGCGCGGG GGAGAAGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046676|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0061700--C:GATOR2 complex
GO:0006914--P:autophagy
GO:0034198--P:cellular response to amino acid starvation
GO:0032008--P:positive regulation of TOR signaling
GO:0010506--P:regulation of autophagy
KEGG hsa:84219
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001294 Ailuropoda melanoleuca 94.61 0.00e+00 1221.00
IUUC-Apl-004177 Anas platyrhynchos 79.38 0.00e+00 1073.00
IUUC-Ago-007803 Ashbya gossypii 21.84 4.00e-17 84.70
IUUC-Acl-008356 Aspergillus clavatus 25.17 1.00e-26 116.00
IUUC-Afu-009013 Aspergillus fumigatus 33.12 9.00e-21 96.70
IUUC-Ani-009185 Aspergillus nidulans 30.00 3.00e-20 95.10
IUUC-Ang-009533 Aspergillus niger 26.34 1.00e-31 132.00
IUUC-Aor-010148 Aspergillus oryzae 31.13 4.00e-23 104.00
IUUC-Ate-010528 Aspergillus terreus 30.81 3.00e-22 101.00
IUUC-Ame-011386 Astyanax mexicanus 56.66 0.00e+00 854.00
IUUC-Bgr-012040 Blumeria graminis 23.10 3.00e-12 68.20
IUUC-Bta-013092 Bos taurus 76.40 0.00e+00 1268.00
IUUC-Bci-013751 Botrytis cinerea 27.23 7.00e-17 83.60
IUUC-Cel-018274 Caenorhabditis elegans 26.64 2.00e-32 136.00
IUUC-Cja-019083 Callithrix jacchus 91.53 0.00e+00 1267.00
IUUC-Cfa-020652 Canis familiaris 94.92 0.00e+00 1166.00
IUUC-Cpo-021847 Cavia porcellus 95.88 0.00e+00 1240.00
IUUC-Csa-023407 Chlorocebus sabaeus 99.05 0.00e+00 1273.00
IUUC-Cin-025129 Ciona intestinalis 31.51 4.00e-100 359.00
IUUC-Csv-025991 Ciona savignyi 31.80 2.00e-79 290.00
IUUC-Cgl-026445 Colletotrichum gloeosporioides 24.51 5.00e-18 87.40
IUUC-Dre-028566 Danio rerio 55.12 0.00e+00 846.00
IUUC-Dno-029775 Dasypus novemcinctus 92.57 0.00e+00 681.00
IUUC-Dor-030655 Dipodomys ordii 79.19 4.00e-137 482.00
IUUC-Dse-031422 Dothistroma septosporum 27.01 5.00e-18 87.40
IUUC-Dme-032155 Drosophila melanogaster 35.57 6.00e-108 385.00
IUUC-Ete-032984 Echinops telfairi 69.41 0.00e+00 1147.00
IUUC-Eca-034065 Equus caballus 96.20 0.00e+00 1223.00
IUUC-Eeu-034460 Erinaceus europaeus 83.94 0.00e+00 1055.00
IUUC-Fca-035432 Felis catus 95.72 0.00e+00 1199.00
IUUC-Fal-037575 Ficedula albicollis 80.70 0.00e+00 1103.00
IUUC-Fox-037810 Fusarium oxysporum 24.44 5.00e-12 67.40
IUUC-Gmo-038937 Gadus morhua 70.00 0.00e+00 877.00
IUUC-Gga-040827 Gallus gallus 80.22 0.00e+00 1098.00
IUUC-Gac-042168 Gasterosteus aculeatus 70.87 0.00e+00 903.00
IUUC-Ggo-044772 Gorilla gorilla 98.80 0.00e+00 1840.00
IUUC-Itr-048506 Ictidomys tridecemlineatus 77.67 0.00e+00 1224.00
IUUC-Kpa-049109 Komagataella pastoris 33.33 3.00e-25 111.00
IUUC-Lch-050410 Latimeria chalumnae 74.19 0.00e+00 997.00
IUUC-Loc-051786 Lepisosteus oculatus 59.91 0.00e+00 986.00
IUUC-Lma-053068 Leptosphaeria maculans 26.00 2.00e-28 122.00
IUUC-Laf-054171 Loxodonta africana 75.35 0.00e+00 1236.00
IUUC-Mcc-055764 Macaca mulatta 90.98 0.00e+00 1641.00
IUUC-Meu-055941 Macropus eugenii 81.79 1.00e-176 613.00
IUUC-Mga-059495 Meleagris gallopavo 80.22 0.00e+00 1098.00
IUUC-Mvi-060314 Microbotryum violaceum 36.36 4.00e-09 58.20
IUUC-Mmr-061375 Microcebus murinus 95.91 0.00e+00 1201.00
IUUC-Mdo-062605 Monodelphis domestica 83.99 0.00e+00 1151.00
IUUC-Mmu-064313 Mus musculus 94.77 0.00e+00 1222.00
IUUC-Mpu-066860 Mustela putorius furo 94.61 0.00e+00 1211.00
IUUC-Mlu-067268 Myotis lucifugus 86.61 0.00e+00 1611.00
IUUC-Nfi-068523 Neosartorya fischeri 33.12 3.00e-21 98.60
IUUC-Opr-070270 Ochotona princeps 90.11 0.00e+00 1123.00
IUUC-Ont-071681 Oreochromis niloticus 57.52 0.00e+00 922.00
IUUC-Ola-086651 Oryzias latipes 69.25 0.00e+00 1229.00
IUUC-Oga-088730 Otolemur garnettii 87.28 0.00e+00 1592.00
IUUC-Oar-090328 Ovis aries 98.39 1.00e-68 252.00
IUUC-Ptr-091668 Pan troglodytes 99.37 0.00e+00 1298.00
IUUC-Pan-092619 Papio anubis 79.07 0.00e+00 1275.00
IUUC-Psi-093906 Pelodiscus sinensis 80.22 0.00e+00 1104.00
IUUC-Pno-094980 Phaeosphaeria nodorum 26.32 4.00e-30 127.00
IUUC-Pfo-096284 Poecilia formosa 58.20 0.00e+00 947.00
IUUC-Pab-097668 Pongo abelii 93.04 0.00e+00 1698.00
IUUC-Pca-100865 Procavia capensis 83.66 0.00e+00 1460.00
IUUC-Pva-102869 Pteropus vampyrus 88.25 0.00e+00 1645.00
IUUC-Pte-104040 Pyrenophora teres 26.48 7.00e-31 130.00
IUUC-Pyt-104648 Pyrenophora triticirepentis 28.63 3.00e-17 85.10
IUUC-Rno-105555 Rattus norvegicus 95.72 0.00e+00 1195.00
IUUC-Sha-106936 Sarcophilus harrisii 80.48 0.00e+00 1469.00
IUUC-Sja-107793 Schizosaccharomyces japonicus 21.62 3.00e-30 127.00
IUUC-Spo-108236 Schizosaccharomyces pombe 25.61 6.00e-25 109.00
IUUC-Ssl-108603 Sclerotinia sclerotiorum 27.23 2.00e-16 82.00
IUUC-Sar-113686 Sorex araneus 90.17 0.00e+00 653.00
IUUC-Ssc-116279 Sus scrofa 88.28 0.00e+00 1652.00
IUUC-Tgu-116557 Taeniopygia guttata 62.31 3.00e-178 618.00
IUUC-Tru-118545 Takifugu rubripes 67.98 0.00e+00 1198.00
IUUC-Tni-120098 Tetraodon nigroviridis 57.75 0.00e+00 946.00
IUUC-Tvi-122484 Trichoderma virens 23.47 2.00e-09 58.90
IUUC-Tme-127028 Tuber melanosporum 31.42 5.00e-42 166.00
IUUC-Ttr-128346 Tursiops truncatus 89.90 0.00e+00 1645.00
IUUC-Vda-129729 Verticillium dahliae 24.30 2.00e-11 65.50
IUUC-Xtr-131862 Xenopus tropicalis 76.20 0.00e+00 861.00
IUUC-Xma-133385 Xiphophorus maculatus 58.20 0.00e+00 948.00
IUUC-Yli-134444 Yarrowia lipolytica 25.39 1.00e-22 102.00
Created Date 25-Jun-2017

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