iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005086

Ensembl Protein ID

ENSACAP00000006937.3

UniProt Accession

H9GC98; H9GC98_ANOCA

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000007014.3	ENSACAT00000007088.3	ENSACAP00000006937.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-24	86.3	1364	1417

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1364 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1417
           58********************************.*****99999*******876 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MDLRNSLNHF QDEQFLGFGL DDAKRAESKG QSPAKSPTAK AGARKPRGRP RSTSDQNSVV 60
LPESLPAYPP LSKPEPTLME KAKKELKGVE KRRGRPPALS SVKFKLSDKE GLPEALKGGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCTCA GGAACAGTCT GAATCATTTC CAGGTAAGCT TTCCAGGCTC CCTCGCCGTG 60
CTACAGGGAC AACCTTCCTT CCAAGCCATG CCATTGGTCC CTTGGTCAGG CTTGGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.62	4.00e-12	66.60
IUUC-Aml-002274	Ailuropoda melanoleuca	66.47	0.00e+00	3644.00
IUUC-Apl-003478	Anas platyrhynchos	82.07	0.00e+00	1712.00
IUUC-Ame-011195	Astyanax mexicanus	42.05	0.00e+00	701.00
IUUC-Bta-012974	Bos taurus	65.90	0.00e+00	3625.00
IUUC-Bdi-014882	Brachypodium distachyon	33.17	2.00e-25	110.00
IUUC-Cja-019226	Callithrix jacchus	64.00	0.00e+00	3905.00
IUUC-Cfa-021049	Canis familiaris	65.64	0.00e+00	3967.00
IUUC-Cpo-021459	Cavia porcellus	65.42	0.00e+00	2830.00
IUUC-Csa-023434	Chlorocebus sabaeus	66.85	0.00e+00	2184.00
IUUC-Cho-024652	Choloepus hoffmanni	65.38	0.00e+00	1879.00
IUUC-Csv-026268	Ciona savignyi	37.66	4.00e-128	452.00
IUUC-Dre-028180	Danio rerio	67.71	0.00e+00	1108.00
IUUC-Dno-029068	Dasypus novemcinctus	62.94	0.00e+00	3372.00
IUUC-Dor-030550	Dipodomys ordii	62.58	0.00e+00	2639.00
IUUC-Ete-032834	Echinops telfairi	55.72	0.00e+00	1579.00
IUUC-Eca-033615	Equus caballus	65.39	0.00e+00	3526.00
IUUC-Eeu-035136	Erinaceus europaeus	71.41	0.00e+00	956.00
IUUC-Fca-036453	Felis catus	54.16	0.00e+00	1308.00
IUUC-Fal-037256	Ficedula albicollis	76.00	0.00e+00	2543.00
IUUC-Gmo-038641	Gadus morhua	65.09	0.00e+00	1058.00
IUUC-Gga-040828	Gallus gallus	67.70	0.00e+00	4031.00
IUUC-Gac-041452	Gasterosteus aculeatus	69.29	0.00e+00	1123.00
IUUC-Gma-043554	Glycine max	47.06	4.00e-37	150.00
IUUC-Ggo-045124	Gorilla gorilla	62.16	0.00e+00	2633.00
IUUC-Hsa-046143	Homo sapiens	65.22	0.00e+00	2857.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	65.48	0.00e+00	2823.00
IUUC-Lch-049704	Latimeria chalumnae	67.37	0.00e+00	1848.00
IUUC-Loc-052181	Lepisosteus oculatus	76.29	0.00e+00	1256.00
IUUC-Laf-053946	Loxodonta africana	65.35	0.00e+00	3489.00
IUUC-Mcc-055508	Macaca mulatta	66.80	0.00e+00	2184.00
IUUC-Meu-056485	Macropus eugenii	58.05	0.00e+00	1562.00
IUUC-Mga-059943	Meleagris gallopavo	66.15	0.00e+00	3762.00
IUUC-Mmr-061178	Microcebus murinus	65.28	0.00e+00	2855.00
IUUC-Mdo-063031	Monodelphis domestica	66.30	0.00e+00	2916.00
IUUC-Mmu-063650	Mus musculus	64.71	0.00e+00	2801.00
IUUC-Mpu-066495	Mustela putorius furo	67.83	0.00e+00	2657.00
IUUC-Mlu-068045	Myotis lucifugus	65.11	0.00e+00	3397.00
IUUC-Nle-069064	Nomascus leucogenys	65.09	0.00e+00	3902.00
IUUC-Opr-071043	Ochotona princeps	61.55	0.00e+00	2278.00
IUUC-Ont-072556	Oreochromis niloticus	63.95	0.00e+00	1093.00
IUUC-Oan-073324	Ornithorhynchus anatinus	69.01	0.00e+00	1850.00
IUUC-Ocu-074190	Oryctolagus cuniculus	64.18	0.00e+00	3790.00
IUUC-Oba-075647	Oryza barthii	48.08	3.00e-37	150.00
IUUC-Ome-081214	Oryza meridionalis	48.08	3.00e-37	150.00
IUUC-Oni-083000	Oryza nivara	48.08	3.00e-37	150.00
IUUC-Opu-083842	Oryza punctata	48.08	3.00e-37	150.00
IUUC-Oru-084361	Oryza rufipogon	48.08	3.00e-37	150.00
IUUC-Ola-087176	Oryzias latipes	62.66	0.00e+00	1093.00
IUUC-Oga-088208	Otolemur garnettii	64.98	0.00e+00	2832.00
IUUC-Oar-090152	Ovis aries	65.88	0.00e+00	3634.00
IUUC-Ptr-091127	Pan troglodytes	65.13	0.00e+00	2851.00
IUUC-Pan-092679	Papio anubis	67.00	0.00e+00	2186.00
IUUC-Psi-094059	Pelodiscus sinensis	74.78	0.00e+00	2524.00
IUUC-Pma-094258	Petromyzon marinus	57.87	0.00e+00	650.00
IUUC-Pfo-096536	Poecilia formosa	62.27	0.00e+00	1084.00
IUUC-Pab-098262	Pongo abelii	65.62	0.00e+00	3888.00
IUUC-Pca-100358	Procavia capensis	62.10	0.00e+00	2658.00
IUUC-Pva-102522	Pteropus vampyrus	60.76	0.00e+00	3031.00
IUUC-Rno-105200	Rattus norvegicus	59.73	0.00e+00	1419.00
IUUC-Sha-107174	Sarcophilus harrisii	66.65	0.00e+00	3612.00
IUUC-Smo-109164	Selaginella moellendorffii	50.65	1.00e-39	158.00
IUUC-Stu-112529	Solanum tuberosum	47.71	7.00e-38	152.00
IUUC-Sar-113503	Sorex araneus	59.54	0.00e+00	1373.00
IUUC-Sbi-114254	Sorghum bicolor	27.27	2.00e-10	60.80
IUUC-Tgu-117047	Taeniopygia guttata	68.48	0.00e+00	4142.00
IUUC-Tru-118328	Takifugu rubripes	63.35	0.00e+00	1116.00
IUUC-Tsy-118953	Tarsius syrichta	55.67	0.00e+00	1724.00
IUUC-Tni-120837	Tetraodon nigroviridis	64.07	0.00e+00	1112.00
IUUC-Tbe-127950	Tupaia belangeri	56.36	0.00e+00	1553.00
IUUC-Ttr-128643	Tursiops truncatus	64.58	0.00e+00	3440.00
IUUC-Vpa-130660	Vicugna pacos	77.70	0.00e+00	1289.00
IUUC-Xtr-132869	Xenopus tropicalis	63.53	0.00e+00	1885.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence