iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069064

Ensembl Protein ID

ENSNLEP00000008984.1

UniProt Accession

G1R712; G1R712_NOMLE

Genbank Protein ID

ENSNLEP00000008984

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01057011

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000007365.1	ENSNLET00000009408.1	ENSNLEP00000008984.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.00e-26	90.9	1336	1389

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1336 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1389
           58********************************.*****99999*******876 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

DEQFLGFGSD EEVRVRSPTR SPSVKTSPRK PRGRPRSGSD RNSAILSDPS VFSPLNKSET 60
KSGDKIKKKD SKSIEKKRGR PPTFPGVKIK ITHGKDISEL PKGNKEDSLK KIKRTPSATF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGAGCA ATTCTTAGGT TTTGGCTCAG ATGAAGAAGT CAGAGTGCGA AGTCCCACAA 60
GGTCTCCTTC AGGTACGGCC AATTAAGTGC ATGGTGCCTT TAAGTTTGTT TGTTAGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0044212--F:transcription regulatory region DNA binding
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0006461--P:protein complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	7.00e-13	69.30
IUUC-Aml-002274	Ailuropoda melanoleuca	94.91	0.00e+00	6084.00
IUUC-Atr-002455	Amborella trichopoda	48.10	7.00e-39	156.00
IUUC-Apl-003478	Anas platyrhynchos	79.31	0.00e+00	3992.00
IUUC-Aca-005086	Anolis carolinensis	65.18	0.00e+00	2930.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	3.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	4.00e-37	150.00
IUUC-Ame-011195	Astyanax mexicanus	43.66	0.00e+00	783.00
IUUC-Bta-012974	Bos taurus	94.49	0.00e+00	6055.00
IUUC-Bol-016540	Brassica oleracea	48.05	1.00e-37	151.00
IUUC-Cja-019226	Callithrix jacchus	96.16	0.00e+00	6209.00
IUUC-Cfa-021049	Canis familiaris	94.73	0.00e+00	6051.00
IUUC-Cpo-021459	Cavia porcellus	93.29	0.00e+00	4319.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	1.00e-38	156.00
IUUC-Csa-023434	Chlorocebus sabaeus	98.99	0.00e+00	5795.00
IUUC-Cho-024652	Choloepus hoffmanni	90.33	0.00e+00	3918.00
IUUC-Cin-025724	Ciona intestinalis	54.46	1.00e-96	348.00
IUUC-Csv-026268	Ciona savignyi	36.96	1.00e-133	471.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	3.00e-12	67.40
IUUC-Dre-028180	Danio rerio	68.35	0.00e+00	1162.00
IUUC-Dno-029068	Dasypus novemcinctus	91.55	0.00e+00	5745.00
IUUC-Dor-030550	Dipodomys ordii	87.20	0.00e+00	5089.00
IUUC-Ete-032834	Echinops telfairi	85.02	0.00e+00	2806.00
IUUC-Eca-033615	Equus caballus	95.56	0.00e+00	5928.00
IUUC-Eeu-035136	Erinaceus europaeus	82.78	0.00e+00	1178.00
IUUC-Fca-036453	Felis catus	91.71	0.00e+00	2693.00
IUUC-Fal-037256	Ficedula albicollis	78.64	0.00e+00	5006.00
IUUC-Gmo-038641	Gadus morhua	67.66	0.00e+00	1093.00
IUUC-Gga-040828	Gallus gallus	79.05	0.00e+00	4945.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.74	0.00e+00	1159.00
IUUC-Gma-043554	Glycine max	49.02	3.00e-38	154.00
IUUC-Ggo-045124	Gorilla gorilla	95.56	0.00e+00	5937.00
IUUC-Hsa-046143	Homo sapiens	99.19	0.00e+00	6215.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	92.88	0.00e+00	5321.00
IUUC-Lch-049704	Latimeria chalumnae	63.91	0.00e+00	3863.00
IUUC-Loc-052181	Lepisosteus oculatus	78.87	0.00e+00	1314.00
IUUC-Laf-053946	Loxodonta africana	94.83	0.00e+00	5837.00
IUUC-Mcc-055508	Macaca mulatta	99.19	0.00e+00	6207.00
IUUC-Meu-056485	Macropus eugenii	81.70	0.00e+00	3034.00
IUUC-Mtr-058327	Medicago truncatula	41.96	4.00e-39	157.00
IUUC-Mla-059141	Melampsora laricipopulina	35.00	1.50e-01	31.20
IUUC-Mga-059943	Meleagris gallopavo	76.43	0.00e+00	4569.00
IUUC-Mmr-061178	Microcebus murinus	94.20	0.00e+00	6044.00
IUUC-Mdo-063031	Monodelphis domestica	86.13	0.00e+00	4033.00
IUUC-Mmu-063650	Mus musculus	89.53	0.00e+00	4147.00
IUUC-Mpu-066495	Mustela putorius furo	95.51	0.00e+00	4165.00
IUUC-Mlu-068045	Myotis lucifugus	85.99	0.00e+00	5427.00
IUUC-Opr-071043	Ochotona princeps	88.03	0.00e+00	4404.00
IUUC-Ont-072556	Oreochromis niloticus	69.95	0.00e+00	1129.00
IUUC-Oan-073324	Ornithorhynchus anatinus	78.11	0.00e+00	2164.00
IUUC-Ocu-074190	Oryctolagus cuniculus	92.93	0.00e+00	5864.00
IUUC-Oba-075647	Oryza barthii	49.36	2.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.71	8.00e-36	145.00
IUUC-Ome-081214	Oryza meridionalis	49.36	2.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.36	2.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	49.36	2.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	49.36	2.00e-38	154.00
IUUC-Oga-088208	Otolemur garnettii	94.94	0.00e+00	5941.00
IUUC-Oar-090152	Ovis aries	94.46	0.00e+00	6079.00
IUUC-Ptr-091127	Pan troglodytes	99.27	0.00e+00	6180.00
IUUC-Pan-092679	Papio anubis	98.99	0.00e+00	5022.00
IUUC-Psi-094059	Pelodiscus sinensis	80.01	0.00e+00	5040.00
IUUC-Pma-094258	Petromyzon marinus	60.47	0.00e+00	684.00
IUUC-Pfo-096536	Poecilia formosa	68.73	0.00e+00	1117.00
IUUC-Pab-098262	Pongo abelii	99.29	0.00e+00	6281.00
IUUC-Pca-100358	Procavia capensis	89.64	0.00e+00	5530.00
IUUC-Pva-102522	Pteropus vampyrus	89.42	0.00e+00	4762.00
IUUC-Rno-105200	Rattus norvegicus	89.80	0.00e+00	4081.00
IUUC-Sha-107174	Sarcophilus harrisii	86.04	0.00e+00	5419.00
IUUC-Smo-109164	Selaginella moellendorffii	51.95	9.00e-41	162.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	5.00e-36	146.00
IUUC-Stu-112529	Solanum tuberosum	48.37	2.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	83.09	0.00e+00	3119.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	8.00e-11	62.40
IUUC-Tgu-117047	Taeniopygia guttata	79.05	0.00e+00	4953.00
IUUC-Tsy-118953	Tarsius syrichta	89.41	0.00e+00	3108.00
IUUC-Tni-120837	Tetraodon nigroviridis	65.99	0.00e+00	1137.00
IUUC-Tbe-127950	Tupaia belangeri	87.92	0.00e+00	2870.00
IUUC-Ttr-128643	Tursiops truncatus	93.24	0.00e+00	5852.00
IUUC-Vpa-130660	Vicugna pacos	90.80	0.00e+00	2015.00
IUUC-Vvi-131476	Vitis vinifera	46.75	3.00e-39	157.00
IUUC-Xtr-132869	Xenopus tropicalis	62.51	0.00e+00	2269.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence