iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	25562820

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-27	93.6	521	558
E3 adaptor/Cullin RING/APC_C/CDC20	1.20e-148	494.7	382	686

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H  +v++l++ +d  ll+sG++D+++ vW+lr++ +++
   Q: 521  HRQEVCGLKWsPDkQLLASGGNDNQLLVWNLRRNEPIQ 558
           999********999******************998887 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl...eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsar 98
           p+kvldapel+ddfylnL+dWss+n+l+v+L+++vylwsa+t++v+kl+dl   +e+d+vtsv+w+++g+llavGt++g+++i+Dv+++kk+r+ltghs+r
   Q: 382  PYKVLDAPELQDDFYLNLVDWSSQNQLSVGLAACVYLWSATTSQVIKLCDLgqtNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSR 482
           79************************************************998899********************************************* PP
   S: 99   vgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLasG 198
           vg+L+Wna++++sGsrd++i+hrd+r++++++ ++l++h+qevCGlkw+ d++lLasGGnDn++ vw+ +++eP++++++h+aavka+awsP++++lL+sG
   Q: 483  VGCLAWNADTICSGSRDRTIMHRDIRCDDNDMgRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSG 583
           ********************************9******************************************************************** PP
   S: 199  GGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlrfwklfdk 299
           GGtaDrc++fwntlt++ ++++dtgsqvc+++wsk+s+elvsthG++ n++++wkypsl+ v++l gh++Rvl+la+spdge+ivt+agDetlrfw++f+k
   Q: 584  GGTADRCLRFWNTLTAQPMQCVDTGSQVCNVAWSKHSSELVSTHGYSFNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWHVFNK 684
           ***************************************************************************************************98 PP
   S: 300  kk 301
            +
   Q: 685  GN 686
           65 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MDEQQPPANS PAIFHSPQAM PVRRTLGPHN SPVKSMSTNS SAHTSPRVTP TKGANPYGDR 60
FMPLRQSNIE WNARYHSINS DDDSGFKKPM GTSSCNRHLG GGQNSAFMSD SSTHPSSSSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTTGCGT GTTCTCCTCA ACTTTACCCT TTTGCACATA AAATGGATGA GCAGCAACCG 60
CCAGCCAACT CTCCGGCTAT TTTTCATTCG CCACAAGCGA TGCCGGTGAG ACGAACCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

cel:CELE_ZK1307.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000670	Aegilops tauschii	58.63	5.00e-105	373.00
IUUC-Aml-002003	Ailuropoda melanoleuca	64.99	5.00e-142	496.00
IUUC-Atr-002753	Amborella trichopoda	61.75	9.00e-116	409.00
IUUC-Apl-003212	Anas platyrhynchos	65.78	9.00e-145	505.00
IUUC-Aca-004920	Anolis carolinensis	45.57	5.00e-79	287.00
IUUC-Aly-005442	Arabidopsis lyrata	51.86	8.00e-123	432.00
IUUC-Ath-006938	Arabidopsis thaliana	61.77	1.00e-121	428.00
IUUC-Ago-007784	Ashbya gossypii	48.77	4.00e-95	340.00
IUUC-Acl-008269	Aspergillus clavatus	53.06	2.00e-119	421.00
IUUC-Afl-008432	Aspergillus flavus	54.35	6.00e-118	416.00
IUUC-Afu-008829	Aspergillus fumigatus	54.20	4.00e-119	420.00
IUUC-Ani-009471	Aspergillus nidulans	53.35	3.00e-118	417.00
IUUC-Ang-009711	Aspergillus niger	53.62	3.00e-118	417.00
IUUC-Aor-010118	Aspergillus oryzae	54.35	6.00e-118	416.00
IUUC-Ate-010534	Aspergillus terreus	53.12	5.00e-118	416.00
IUUC-Ame-010685	Astyanax mexicanus	68.93	1.00e-140	491.00
IUUC-Bgr-012013	Blumeria graminis	57.19	3.00e-115	407.00
IUUC-Bta-012586	Bos taurus	64.92	3.00e-144	503.00
IUUC-Bci-013807	Botrytis cinerea	58.59	4.00e-110	390.00
IUUC-Bdi-014981	Brachypodium distachyon	63.19	6.00e-117	413.00
IUUC-Bol-015548	Brassica oleracea	56.28	9.00e-118	416.00
IUUC-Bra-018065	Brassica rapa	55.76	3.00e-117	414.00
IUUC-Cja-019929	Callithrix jacchus	64.99	4.00e-143	499.00
IUUC-Cfa-020977	Canis familiaris	64.99	5.00e-143	499.00
IUUC-Cpo-021537	Cavia porcellus	65.51	5.00e-144	503.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	49.25	2.00e-90	325.00
IUUC-Csa-023389	Chlorocebus sabaeus	65.24	1.00e-143	501.00
IUUC-Cho-024920	Choloepus hoffmanni	50.42	4.00e-31	127.00
IUUC-Cin-025327	Ciona intestinalis	68.01	3.00e-143	500.00
IUUC-Csv-025921	Ciona savignyi	64.51	3.00e-146	510.00
IUUC-Cgl-026631	Colletotrichum gloeosporioides	53.37	1.00e-114	405.00
IUUC-Cne-026933	Cryptococcus neoformans	56.89	1.00e-116	412.00
IUUC-Cme-027143	Cyanidioschyzon merolae	60.00	2.00e-110	392.00
IUUC-Dre-027470	Danio rerio	69.85	9.00e-141	492.00
IUUC-Dno-029629	Dasypus novemcinctus	64.20	3.00e-127	447.00
IUUC-Dor-030187	Dipodomys ordii	62.44	2.00e-137	481.00
IUUC-Dse-031502	Dothistroma septosporum	56.63	1.00e-108	385.00
IUUC-Dme-031858	Drosophila melanogaster	64.17	1.00e-143	501.00
IUUC-Ete-032562	Echinops telfairi	70.64	3.00e-93	334.00
IUUC-Eca-034210	Equus caballus	65.51	6.00e-144	502.00
IUUC-Eeu-035059	Erinaceus europaeus	41.27	1.00e-66	246.00
IUUC-Fca-035839	Felis catus	65.51	8.00e-144	502.00
IUUC-Fal-036895	Ficedula albicollis	65.78	9.00e-145	505.00
IUUC-Fox-037814	Fusarium oxysporum	58.81	3.00e-111	393.00
IUUC-Fso-038420	Fusarium solani	56.32	1.00e-114	405.00
IUUC-Gmo-039544	Gadus morhua	60.33	4.00e-142	496.00
IUUC-Ggr-039774	Gaeumannomyces graminis	58.90	8.00e-115	406.00
IUUC-Gga-041025	Gallus gallus	65.78	2.00e-144	504.00
IUUC-Gac-041596	Gasterosteus aculeatus	64.58	2.00e-142	497.00
IUUC-Gma-043563	Glycine max	62.21	2.00e-114	404.00
IUUC-Ggo-045599	Gorilla gorilla	68.34	4.00e-139	486.00
IUUC-Hsa-046695	Homo sapiens	64.72	1.00e-142	498.00
IUUC-Hvu-047486	Hordeum vulgare	60.00	4.00e-98	349.00
IUUC-Itr-048192	Ictidomys tridecemlineatus	65.78	2.00e-144	504.00
IUUC-Kpa-049239	Komagataella pastoris	52.85	4.00e-113	400.00
IUUC-Lch-049827	Latimeria chalumnae	69.25	1.00e-140	491.00
IUUC-Lpe-051568	Leersia perrieri	60.27	1.00e-104	372.00
IUUC-Loc-052856	Lepisosteus oculatus	64.89	9.00e-141	492.00
IUUC-Lma-052998	Leptosphaeria maculans	42.26	4.00e-74	271.00
IUUC-Laf-053742	Loxodonta africana	48.42	7.00e-85	306.00
IUUC-Mcc-055601	Macaca mulatta	65.24	1.00e-143	501.00
IUUC-Meu-056276	Macropus eugenii	64.22	8.00e-126	442.00
IUUC-Mor-057113	Magnaporthe oryzae	56.20	1.00e-114	405.00
IUUC-Mpo-057599	Magnaporthe poae	58.90	5.00e-115	407.00
IUUC-Mtr-057689	Medicago truncatula	57.46	2.00e-116	410.00
IUUC-Mla-059048	Melampsora laricipopulina	53.22	1.00e-101	362.00
IUUC-Mga-060097	Meleagris gallopavo	61.64	8.00e-133	465.00
IUUC-Mvi-060465	Microbotryum violaceum	55.30	1.00e-113	402.00
IUUC-Mmr-061151	Microcebus murinus	57.26	5.00e-114	403.00
IUUC-Mdo-063062	Monodelphis domestica	65.78	9.00e-145	505.00
IUUC-Mmu-063731	Mus musculus	65.24	1.00e-143	501.00
IUUC-Mac-064942	Musa acuminata	57.92	9.00e-122	428.00
IUUC-Mpu-066173	Mustela putorius furo	65.51	3.00e-144	503.00
IUUC-Mlu-068030	Myotis lucifugus	64.99	7.00e-143	499.00
IUUC-Nfi-068536	Neosartorya fischeri	54.20	5.00e-119	420.00
IUUC-Ncr-068734	Neurospora crassa	58.90	1.00e-114	405.00
IUUC-Nle-070163	Nomascus leucogenys	65.24	1.00e-143	502.00
IUUC-Opr-070974	Ochotona princeps	67.69	6.00e-115	405.00
IUUC-Ont-072507	Oreochromis niloticus	65.24	1.00e-144	505.00
IUUC-Oan-073634	Ornithorhynchus anatinus	69.93	3.00e-125	439.00
IUUC-Ocu-073797	Oryctolagus cuniculus	48.42	2.00e-85	308.00
IUUC-Oba-075417	Oryza barthii	60.61	1.00e-104	372.00
IUUC-Obr-076033	Oryza brachyantha	62.63	2.00e-111	394.00
IUUC-Ogl-077441	Oryza glaberrima	62.63	3.00e-111	394.00
IUUC-Ogu-077996	Oryza glumaepatula	62.87	8.00e-115	405.00
IUUC-Oin-080172	Oryza indica	63.19	5.00e-116	409.00
IUUC-Olo-081068	Oryza longistaminata	63.19	4.00e-116	409.00
IUUC-Ome-081250	Oryza meridionalis	63.19	6.00e-116	409.00
IUUC-Oni-083048	Oryza nivara	63.19	6.00e-116	409.00
IUUC-Opu-083333	Oryza punctata	63.19	5.00e-116	409.00
IUUC-Oru-085001	Oryza rufipogon	63.19	6.00e-116	409.00
IUUC-Osa-085451	Oryza sativa	62.63	3.00e-111	394.00
IUUC-Ola-087094	Oryzias latipes	64.34	9.00e-142	495.00
IUUC-Olu-087647	Ostreococcus lucimarinus	47.31	3.00e-93	334.00
IUUC-Oga-088911	Otolemur garnettii	65.51	5.00e-144	503.00
IUUC-Oar-089508	Ovis aries	64.92	3.00e-144	503.00
IUUC-Ptr-090935	Pan troglodytes	48.57	3.00e-85	307.00
IUUC-Pan-092147	Papio anubis	64.72	1.00e-142	498.00
IUUC-Psi-093702	Pelodiscus sinensis	65.33	2.00e-144	504.00
IUUC-Pma-094581	Petromyzon marinus	61.66	3.00e-135	473.00
IUUC-Pno-095139	Phaeosphaeria nodorum	55.66	1.00e-107	382.00
IUUC-Ppa-095366	Physcomitrella patens	61.96	1.00e-122	432.00
IUUC-Pfo-096309	Poecilia formosa	64.84	2.00e-142	498.00
IUUC-Pab-098603	Pongo abelii	48.89	1.00e-85	308.00
IUUC-Pop-099953	Populus trichocarpa	63.00	1.00e-112	398.00
IUUC-Pca-100565	Procavia capensis	68.62	8.00e-141	492.00
IUUC-Ppe-101924	Prunus persica	56.23	2.00e-115	408.00
IUUC-Pva-102602	Pteropus vampyrus	62.92	3.00e-137	480.00
IUUC-Pgr-103466	Puccinia graminis	53.53	2.00e-105	374.00
IUUC-Ptt-103888	Puccinia triticina	53.07	2.00e-96	345.00
IUUC-Pte-104097	Pyrenophora teres	55.59	6.00e-117	413.00
IUUC-Pyt-104445	Pyrenophora triticirepentis	48.35	1.00e-100	358.00
IUUC-Rno-105028	Rattus norvegicus	65.24	1.00e-143	501.00
IUUC-Sce-106240	Saccharomyces cerevisiae	47.85	5.00e-93	333.00
IUUC-Sha-106538	Sarcophilus harrisii	56.65	1.00e-124	438.00
IUUC-Sja-107900	Schizosaccharomyces japonicus	55.21	7.00e-109	385.00
IUUC-Spo-108056	Schizosaccharomyces pombe	55.52	2.00e-108	384.00
IUUC-Ssl-108391	Sclerotinia sclerotiorum	54.03	3.00e-111	394.00
IUUC-Smo-108878	Selaginella moellendorffii	58.77	4.00e-124	437.00
IUUC-Sit-110550	Setaria italica	59.23	3.00e-117	413.00
IUUC-Sly-111446	Solanum lycopersicum	60.74	7.00e-116	409.00
IUUC-Stu-112491	Solanum tuberosum	61.04	3.00e-116	410.00
IUUC-Sar-113092	Sorex araneus	43.68	3.00e-77	281.00
IUUC-Sbi-114489	Sorghum bicolor	64.17	7.00e-113	399.00
IUUC-Sre-115222	Sporisorium reilianum	58.46	6.00e-113	400.00
IUUC-Ssc-116171	Sus scrofa	64.92	2.00e-144	504.00
IUUC-Tgu-116878	Taeniopygia guttata	55.58	4.00e-114	403.00
IUUC-Tru-118222	Takifugu rubripes	64.51	1.00e-141	495.00
IUUC-Tsy-118931	Tarsius syrichta	37.84	2.00e-54	205.00
IUUC-Tni-119863	Tetraodon nigroviridis	64.83	4.00e-143	499.00
IUUC-Tca-121599	Theobroma cacao	57.63	4.00e-114	403.00
IUUC-Tre-122249	Trichoderma reesei	54.30	2.00e-115	407.00
IUUC-Tvi-122675	Trichoderma virens	54.30	8.00e-116	409.00
IUUC-Tae-123028	Triticum aestivum	57.77	1.00e-117	415.00
IUUC-Tur-126545	Triticum urartu	54.40	3.00e-95	340.00
IUUC-Tme-127151	Tuber melanosporum	57.06	2.00e-124	437.00
IUUC-Tbe-128056	Tupaia belangeri	62.21	5.00e-110	389.00
IUUC-Ttr-129055	Tursiops truncatus	64.42	2.00e-143	501.00
IUUC-Uma-129555	Ustilago maydis	58.15	5.00e-113	400.00
IUUC-Vda-130027	Verticillium dahliae	56.32	2.00e-115	408.00
IUUC-Vpa-130775	Vicugna pacos	36.11	3.00e-53	201.00
IUUC-Vvi-131749	Vitis vinifera	57.63	4.00e-117	413.00
IUUC-Xtr-132808	Xenopus tropicalis	64.71	4.00e-144	503.00
IUUC-Xma-133183	Xiphophorus maculatus	64.84	2.00e-142	498.00
IUUC-Yli-134584	Yarrowia lipolytica	59.50	3.00e-122	431.00
IUUC-Zma-135640	Zea mays	61.66	1.00e-116	412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence