iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133987

Ensembl Protein ID

ENSXMAP00000019415.1

UniProt Accession

M4AY70; M4AY70_XIPMA

Genbank Protein ID

ENSXMAP00000019415

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01004191

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000019367.1	ENSXMAT00000019443.1	ENSXMAP00000019415.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-136	455.2	510	842

Active Site

Position(s)	Description	Evidence
811	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 510  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 597
           5899********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl +ik+n   +iee+gl++ fsv++eilge++++eLkp+G nipVt++NkeeY++lv+e
   Q: 598  GFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDN---NIEECGLEMFFSVDKEILGEVSTHELKPDGGNIPVTEDNKEEYIRLVAE 683
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d++++t y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 684  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLVDWQRNTIYRH-YARSSKQILWFWQFVKEMDNEKRMRLLQFV 771
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 772  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 842
           *********************************************************************96 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MKAQLQVTVL SAKLKENKKN WFGPSPYVEV AVDGQSKRTE KCNNTHSPKW KQALTVIVTP 60
VSKLIFRVWS HQTLKSDILL GMATLDIGTV LKANDLKLCE VVQTLQLSFD RDPQDIVGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAATTTA GCTAGTGTTA CTGAAGTCCC TGTTAATGGC TGATATGTAA CTGTCAACAA 60
TTCTGGGGTT GCTGAGACCG AAGCCCTTTT ACGATCCATT ACTCTCTGTG TTTCACAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010601	Astyanax mexicanus	93.16	0.00e+00	1167.00
IUUC-Bta-012782	Bos taurus	90.05	0.00e+00	1118.00
IUUC-Cja-018899	Callithrix jacchus	89.04	0.00e+00	1128.00
IUUC-Cho-024695	Choloepus hoffmanni	89.04	0.00e+00	1134.00
IUUC-Dre-028809	Danio rerio	93.46	0.00e+00	1159.00
IUUC-Dno-029884	Dasypus novemcinctus	73.43	0.00e+00	1314.00
IUUC-Eeu-034716	Erinaceus europaeus	84.72	0.00e+00	828.00
IUUC-Fal-037126	Ficedula albicollis	88.81	0.00e+00	1122.00
IUUC-Gmo-038596	Gadus morhua	85.18	0.00e+00	1054.00
IUUC-Gac-041520	Gasterosteus aculeatus	95.25	0.00e+00	1189.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	88.53	0.00e+00	1125.00
IUUC-Lch-050454	Latimeria chalumnae	88.72	0.00e+00	1124.00
IUUC-Loc-052647	Lepisosteus oculatus	78.30	0.00e+00	1381.00
IUUC-Mdo-062505	Monodelphis domestica	88.55	0.00e+00	1127.00
IUUC-Mmu-063375	Mus musculus	89.21	0.00e+00	1134.00
IUUC-Opr-070585	Ochotona princeps	88.53	0.00e+00	1121.00
IUUC-Ont-071798	Oreochromis niloticus	96.75	0.00e+00	1208.00
IUUC-Ocu-074298	Oryctolagus cuniculus	89.21	0.00e+00	1133.00
IUUC-Pfo-096937	Poecilia formosa	99.32	0.00e+00	1235.00
IUUC-Pab-097580	Pongo abelii	80.14	0.00e+00	996.00
IUUC-Rno-104924	Rattus norvegicus	85.76	0.00e+00	1132.00
IUUC-Sha-107175	Sarcophilus harrisii	88.38	0.00e+00	1127.00
IUUC-Sar-113761	Sorex araneus	89.70	0.00e+00	1112.00
IUUC-Sre-114929	Sporisorium reilianum	47.08	1.00e-153	537.00
IUUC-Tgu-116632	Taeniopygia guttata	83.48	0.00e+00	1032.00
IUUC-Tru-118442	Takifugu rubripes	92.39	0.00e+00	1147.00
IUUC-Tni-120168	Tetraodon nigroviridis	95.47	0.00e+00	1129.00
IUUC-Tbe-127756	Tupaia belangeri	74.10	0.00e+00	826.00
IUUC-Vpa-130103	Vicugna pacos	77.23	0.00e+00	949.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence