iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096533

Ensembl Protein ID

ENSPFOP00000016694.2

UniProt Accession

A0A087YF91; A0A087YF91_POEFO

Genbank Protein ID

ENSPFOP00000016694

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01000412

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000016531.2	ENSPFOT00000030245.1	ENSPFOP00000024784.1
ENSPFOG00000016531.2	ENSPFOT00000016716.2	ENSPFOP00000016694.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.20e-195	648.4	405	891

Active Site

Position(s)	Description	Evidence
586	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD Qi ++G+e q+kl ++k+++vGag++GcEllKn++l+G+     g itv+Dmd +e snlnrqFLfr +d+gk+K+evaa+a++e+
   Q: 405  YDAQIVVFGSEFQQKLLNQKYFMVGAGAIGCELLKNFALIGIgagekGRITVTDMDYIERSNLNRQFLFRSKDIGKPKSEVAAKAVAEM 493
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++++ah+++++++ e ++   Ff  +d+V++aldn+ear +++++c+++++p++e+gtlG +G++ v++++lte+y   + +  + 
   Q: 494  NPQIKITAHQNRLDPDSEGVYdysFFMGLDGVAAALDNVEARVYLDKRCVQHQKPMLEGGTLGSKGHTLVVVPHLTESYGPGKSSSGNA 582
           *******************99******************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeeg..k..dkvkselksedeenfeeaieiavk 243
           iP+ctlk++p  +eht++wa            + +n +l + ++ e +l   d+e+ e        + + e+ + +++++e+++ +a++
   Q: 583  IPLCTLKNFPHRIEHTLQWArdqfeglfkqtpENVNLFLRDPNFIERTLTHGDAEALEILggVciSLQEMEAGGHRPKSWEDCVGWARR 671
           *********************999999999999999999888888888887665555432112113334445559************** PP
   S: 244  afakttinsikqllksfecdivtkskspfwv........................................................sf 276
           +++++++n+i+qll++f+++++t+++ pfw+                                                        s 
   Q: 672  KWETQYNNEIRQLLHCFPPGELTSNGLPFWSgskrcphpltfdpnntthieyvvaaanlygqiygiegtrdcaaikntlervsvppfSP 760
           *************************************************************************9999999997776644 PP
   S: 277  csnaealqvpekvekdeevvkasap...lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlike 360
           +s ++ + +++ +e+d+++  ++ +   l+ l+ +l+++++  + +p  ++fekddds  ++d + aa+nlrae+++i++ +d+++ k+
   Q: 761  KSSVKIHLTDKEMEEDRKKEGDDTDkaqLEELKGKLSSLKSAAQMYP--IDFEKDDDSnfHMDYIVAASNLRAENYDIPA-ADRHQSKR 846
           44444444555555555544444445558888888888888888887..*******************************.******** PP
   S: 361  iagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfda 403
           iag+iipaiatt+a+v+Gl ++E++K+++g  k e +++ +l++a
   Q: 847  IAGRIIPAIATTTAAVAGLMCLELFKLIQGhkKIESYRTAYLNLA 891
           ******************************877888888888866 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MAETGAIDEG FYSRQLYVLG HEAMRRMATA EVLIAGMKGL GVEIAKNVIL SGVKSVTVQD 60
EGQADWSDLS SQFFLHESDL GQNRATSSIP QLTALNPHVF VSAHTGPLNE DLLLNYQVVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGCAA TCTTGATTTC TATTAAAAGT CCTGATCCGC CCCCTAGTGG CCAACATACG 60
AAGGCACACA ATTTATTTAT TTTTTTTAAA TGATCTTTTT GTGAAGTCAC TGAGGAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Dre-028625	Danio rerio	65.52	0.00e+00	1317.00
IUUC-Gmo-038576	Gadus morhua	66.70	0.00e+00	1321.00
IUUC-Gac-041448	Gasterosteus aculeatus	75.22	0.00e+00	1541.00
IUUC-Loc-052317	Lepisosteus oculatus	63.89	0.00e+00	1287.00
IUUC-Ont-072192	Oreochromis niloticus	78.60	0.00e+00	1638.00
IUUC-Ola-086982	Oryzias latipes	72.33	0.00e+00	1285.00
IUUC-Tru-118769	Takifugu rubripes	68.95	0.00e+00	1317.00
IUUC-Tni-119935	Tetraodon nigroviridis	67.65	0.00e+00	1204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence