iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059310

Ensembl Protein ID

ENSMGAP00000010110.1

UniProt Accession

G1NBR9; G1NBR9_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000009755.1	ENSMGAT00000010956.1	ENSMGAP00000010110.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-15	56.4	94	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L++kkG+  ++i  ++++++W+++ + ++gk G +P+n+v+ ++
   Q: 94   FVALYDYEARTTDDLSFKKGERFQII--NNTEGDWWEARSIATGKTGYIPSNYVAPAD 149
           789***********************..8999**********************9875 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV NFNSHSMTPF 60
GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY EARTTDDLSF KKGERFQIIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAAGCGAC CATGGGGTGC ATTAAAAGCA AAGAAGATAA AGGTCCAGCC ATGAAATACA 60
GGACTGATAA CACTCCAGAA CCTATTAGTT CCCACGTCAG CCATTACGGG TCAGACTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	92.25	0.00e+00	1021.00
IUUC-Apl-004032	Anas platyrhynchos	99.63	0.00e+00	1100.00
IUUC-Aca-004255	Anolis carolinensis	94.64	0.00e+00	1081.00
IUUC-Ame-010954	Astyanax mexicanus	88.12	0.00e+00	1006.00
IUUC-Bta-013503	Bos taurus	91.13	0.00e+00	991.00
IUUC-Cel-018682	Caenorhabditis elegans	58.17	2.00e-150	525.00
IUUC-Cja-019694	Callithrix jacchus	91.53	0.00e+00	1003.00
IUUC-Cfa-020402	Canis familiaris	92.05	0.00e+00	1019.00
IUUC-Cpo-022506	Cavia porcellus	92.42	0.00e+00	1021.00
IUUC-Csa-023713	Chlorocebus sabaeus	92.27	0.00e+00	1013.00
IUUC-Cin-025390	Ciona intestinalis	71.64	0.00e+00	667.00
IUUC-Csv-026029	Ciona savignyi	63.98	0.00e+00	645.00
IUUC-Dre-027978	Danio rerio	86.63	0.00e+00	972.00
IUUC-Dno-029897	Dasypus novemcinctus	90.76	0.00e+00	910.00
IUUC-Dor-030202	Dipodomys ordii	95.58	0.00e+00	914.00
IUUC-Eca-034157	Equus caballus	91.50	0.00e+00	1014.00
IUUC-Eeu-034950	Erinaceus europaeus	88.64	7.00e-174	602.00
IUUC-Fca-036233	Felis catus	92.05	0.00e+00	1057.00
IUUC-Fal-037461	Ficedula albicollis	98.52	0.00e+00	1117.00
IUUC-Gmo-038929	Gadus morhua	84.34	0.00e+00	922.00
IUUC-Gga-041107	Gallus gallus	100.00	0.00e+00	1103.00
IUUC-Gac-042321	Gasterosteus aculeatus	85.43	0.00e+00	956.00
IUUC-Hsa-047010	Homo sapiens	91.90	0.00e+00	1017.00
IUUC-Lch-050239	Latimeria chalumnae	91.87	0.00e+00	1043.00
IUUC-Loc-052314	Lepisosteus oculatus	90.46	0.00e+00	979.00
IUUC-Laf-053517	Loxodonta africana	92.05	0.00e+00	999.00
IUUC-Mcc-055626	Macaca mulatta	92.27	0.00e+00	1013.00
IUUC-Meu-056155	Macropus eugenii	76.05	0.00e+00	724.00
IUUC-Mmr-061652	Microcebus murinus	91.87	0.00e+00	1016.00
IUUC-Mdo-062963	Monodelphis domestica	91.68	0.00e+00	1029.00
IUUC-Mmu-064128	Mus musculus	90.94	0.00e+00	1025.00
IUUC-Mpu-065906	Mustela putorius furo	92.42	0.00e+00	1024.00
IUUC-Mlu-067035	Myotis lucifugus	92.46	0.00e+00	1022.00
IUUC-Nle-069041	Nomascus leucogenys	87.85	0.00e+00	958.00
IUUC-Opr-070299	Ochotona princeps	82.99	0.00e+00	891.00
IUUC-Ont-072337	Oreochromis niloticus	87.39	0.00e+00	980.00
IUUC-Oan-072997	Ornithorhynchus anatinus	98.03	0.00e+00	940.00
IUUC-Ocu-074171	Oryctolagus cuniculus	92.24	0.00e+00	1024.00
IUUC-Oba-075994	Oryza barthii	34.98	2.00e-21	97.40
IUUC-Ogl-077331	Oryza glaberrima	34.85	4.00e-23	103.00
IUUC-Ola-086619	Oryzias latipes	84.39	0.00e+00	973.00
IUUC-Oga-087957	Otolemur garnettii	91.68	0.00e+00	1008.00
IUUC-Oar-089670	Ovis aries	90.02	0.00e+00	1009.00
IUUC-Ptr-091352	Pan troglodytes	91.90	0.00e+00	1017.00
IUUC-Pan-092202	Papio anubis	92.27	0.00e+00	1013.00
IUUC-Psi-093310	Pelodiscus sinensis	97.23	0.00e+00	1107.00
IUUC-Pma-094232	Petromyzon marinus	86.23	0.00e+00	864.00
IUUC-Pfo-096137	Poecilia formosa	84.09	0.00e+00	956.00
IUUC-Pab-098301	Pongo abelii	96.08	0.00e+00	946.00
IUUC-Pva-102592	Pteropus vampyrus	87.80	0.00e+00	962.00
IUUC-Rno-105544	Rattus norvegicus	90.94	0.00e+00	998.00
IUUC-Sar-113364	Sorex araneus	88.54	0.00e+00	949.00
IUUC-Tgu-117380	Taeniopygia guttata	98.52	0.00e+00	1117.00
IUUC-Tru-117784	Takifugu rubripes	85.37	0.00e+00	965.00
IUUC-Tni-120433	Tetraodon nigroviridis	84.99	0.00e+00	954.00
IUUC-Ttr-128893	Tursiops truncatus	91.68	0.00e+00	1014.00
IUUC-Vpa-130060	Vicugna pacos	92.24	0.00e+00	1014.00
IUUC-Xtr-132322	Xenopus tropicalis	93.16	0.00e+00	1049.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence