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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046794
Ensembl Protein ID ENSP00000339449.5
UniProt Accession Q8N1V2; B2RDU7; Q5DX23; Q8TC73; Q8TCI3; CFA52_HUMAN
Genbank Protein ID BAB83743.1; BAB85083.1; BAC04435.1; BAG38044.1; AAH25392.1
Protein Name Cilia- and flagella-associated protein 52; WD repeat-containing protein 16; WD40-repeat protein up-regulated in HCC
Genbank Nucleotide ID AB065281; AK074435; AK094847; AK315679; AC087501
Gene Name CFAP52; WDR16; WDRPUH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166596.14 ENST00000396219.7 ENSP00000379521.3
ENSG00000166596.14 ENST00000352665.9 ENSP00000339449.5
ENSG00000166596.14 ENST00000575247.5 ENSP00000459671.1
ENSG00000166596.14 ENST00000574937.5 ENSP00000459347.1
ENSG00000166596.14 ENST00000576630.5 ENSP00000458343.2
ENSG00000166596.14 ENST00000576499.1 ENSP00000476293.1
ENSG00000166596.14 ENST00000574097.1 ENSP00000468193.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.20e-33 112.7 460 491
UBD/Beta-Prp 2.30e-58 199.4 504 614
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlr 31
           H++sv+c++   ++   v++s Dgt+ +WDl 
   Q: 460  HKSSVSCIRVkrNNEECVTASTDGTCIIWDLV 491
           9**********76699**************85 PP
   

   UBD/Beta-Prp
   S: 139  vvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrf 230
           + +cv++hp+++ ++++++Dr++  W +  g+++r+l+g   +s++ ++++++g ++v+g++d  vk+wd+ +ge+ +   gh+ n++++r 
   Q: 504  LFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRI 595
           578***************************************************************************************** PP
   S: 231  spnderlvsgssDgsiriW 249
           sp ++++vs+s+Dg i  W
   Q: 596  SPGNQYIVSVSADGAILRW 614
           ****************999 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in cell growth and/or survival.
 May play a role in cell growth and/or survival.
Protein Sequence
(Fasta)
MDNKISPEAQ VAELELDAVI GFNGHVPTGL KCHPDQEHMI YPLGCTVLIQ AINTKEQNFL 60
QGHGNNVSCL AISRSGEYIA SGQVTFMGFK ADIILWDYKN RELLARLSLH KGKIEALAFS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046794|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTACCATAA CGACCAGAAG ACGCTGCAGC CACTAGGGAG GAGAGCAAAG TAATCAGAAC 60
CTCCCAAGGA TGGATAACAA AATTTCGCCG GAGGCCCAAG TGGCGGAGCT GGAACTTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046794|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR033015--CFAP52
IPR003143--Cyt_cd1_C
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
KEGG hsa:146845
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002048 Ailuropoda melanoleuca 92.42 0.00e+00 1175.00
IUUC-Apl-004011 Anas platyrhynchos 71.14 0.00e+00 910.00
IUUC-Aca-004805 Anolis carolinensis 72.45 0.00e+00 962.00
IUUC-Ame-010655 Astyanax mexicanus 62.15 0.00e+00 800.00
IUUC-Bta-013493 Bos taurus 92.35 0.00e+00 1144.00
IUUC-Cja-019923 Callithrix jacchus 95.81 0.00e+00 1213.00
IUUC-Cfa-020609 Canis familiaris 92.74 0.00e+00 1167.00
IUUC-Cpo-022158 Cavia porcellus 88.89 0.00e+00 1134.00
IUUC-Cre-022705 Chlamydomonas reinhardtii 45.63 6.00e-164 570.00
IUUC-Csa-023338 Chlorocebus sabaeus 97.10 0.00e+00 1229.00
IUUC-Cho-024884 Choloepus hoffmanni 86.45 0.00e+00 725.00
IUUC-Cin-025634 Ciona intestinalis 62.50 0.00e+00 805.00
IUUC-Csv-026211 Ciona savignyi 64.63 7.00e-97 346.00
IUUC-Dre-028268 Danio rerio 64.32 0.00e+00 875.00
IUUC-Dno-029202 Dasypus novemcinctus 85.69 0.00e+00 1046.00
IUUC-Dor-030197 Dipodomys ordii 78.80 0.00e+00 745.00
IUUC-Dme-032037 Drosophila melanogaster 35.96 2.00e-111 396.00
IUUC-Ete-033049 Echinops telfairi 81.21 0.00e+00 977.00
IUUC-Eca-033884 Equus caballus 92.58 0.00e+00 1155.00
IUUC-Eeu-034477 Erinaceus europaeus 77.93 2.00e-174 605.00
IUUC-Fca-035453 Felis catus 90.73 0.00e+00 1145.00
IUUC-Gmo-039448 Gadus morhua 65.59 2.00e-113 402.00
IUUC-Gga-040295 Gallus gallus 70.96 0.00e+00 944.00
IUUC-Gac-042074 Gasterosteus aculeatus 56.87 0.00e+00 719.00
IUUC-Ggo-044438 Gorilla gorilla 99.17 0.00e+00 964.00
IUUC-Itr-048315 Ictidomys tridecemlineatus 93.37 0.00e+00 684.00
IUUC-Lch-050554 Latimeria chalumnae 66.90 0.00e+00 815.00
IUUC-Loc-052080 Lepisosteus oculatus 67.98 0.00e+00 900.00
IUUC-Laf-054288 Loxodonta africana 91.77 0.00e+00 1145.00
IUUC-Mcc-055746 Macaca mulatta 89.84 0.00e+00 1110.00
IUUC-Meu-056507 Macropus eugenii 75.82 7.00e-151 527.00
IUUC-Mga-059858 Meleagris gallopavo 71.07 0.00e+00 898.00
IUUC-Mmr-061757 Microcebus murinus 94.22 0.00e+00 1028.00
IUUC-Mdo-062670 Monodelphis domestica 81.91 0.00e+00 1087.00
IUUC-Mmu-064084 Mus musculus 90.81 0.00e+00 1167.00
IUUC-Mpu-066253 Mustela putorius furo 91.29 0.00e+00 1140.00
IUUC-Mlu-067944 Myotis lucifugus 73.78 0.00e+00 902.00
IUUC-Nle-069098 Nomascus leucogenys 97.74 0.00e+00 1232.00
IUUC-Opr-070525 Ochotona princeps 83.09 0.00e+00 906.00
IUUC-Ont-071609 Oreochromis niloticus 59.61 0.00e+00 777.00
IUUC-Oan-073543 Ornithorhynchus anatinus 77.87 0.00e+00 1003.00
IUUC-Ocu-074209 Oryctolagus cuniculus 91.29 0.00e+00 1176.00
IUUC-Ola-086464 Oryzias latipes 57.17 0.00e+00 737.00
IUUC-Olu-087600 Ostreococcus lucimarinus 34.09 9.00e-98 351.00
IUUC-Oga-088977 Otolemur garnettii 91.45 0.00e+00 1173.00
IUUC-Oar-089192 Ovis aries 91.85 0.00e+00 1142.00
IUUC-Ptr-090882 Pan troglodytes 94.14 0.00e+00 1150.00
IUUC-Pan-092865 Papio anubis 91.97 0.00e+00 1156.00
IUUC-Psi-093270 Pelodiscus sinensis 75.98 0.00e+00 857.00
IUUC-Pma-094291 Petromyzon marinus 62.94 0.00e+00 854.00
IUUC-Ppa-095984 Physcomitrella patens 42.06 3.00e-146 512.00
IUUC-Pfo-097344 Poecilia formosa 50.97 0.00e+00 686.00
IUUC-Pab-098278 Pongo abelii 97.74 0.00e+00 1232.00
IUUC-Pca-101037 Procavia capensis 92.11 0.00e+00 1136.00
IUUC-Pva-102351 Pteropus vampyrus 91.91 0.00e+00 964.00
IUUC-Rno-105262 Rattus norvegicus 90.65 0.00e+00 1165.00
IUUC-Smo-109009 Selaginella moellendorffii 45.16 9.00e-166 577.00
IUUC-Sar-113156 Sorex araneus 76.66 6.00e-136 478.00
IUUC-Ssc-116319 Sus scrofa 93.50 1.00e-66 244.00
IUUC-Tru-117963 Takifugu rubripes 55.81 0.00e+00 726.00
IUUC-Tsy-119115 Tarsius syrichta 71.98 0.00e+00 814.00
IUUC-Tni-120388 Tetraodon nigroviridis 54.65 0.00e+00 697.00
IUUC-Tbe-127930 Tupaia belangeri 81.25 1.00e-178 620.00
IUUC-Ttr-128981 Tursiops truncatus 90.60 0.00e+00 1094.00
IUUC-Vpa-130492 Vicugna pacos 84.40 0.00e+00 1047.00
IUUC-Xtr-132142 Xenopus tropicalis 68.89 0.00e+00 932.00
Created Date 25-Jun-2017

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