iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035454

Ensembl Protein ID

ENSFCAP00000025067.1

UniProt Accession

M3XEK9; M3XEK9_FELCA

Genbank Protein ID

ENSFCAP00000025067

Protein Name

E3 ubiquitin-protein ligase Mdm2

Genbank Nucleotide ID

AANG02029425

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000024456.1	ENSFCAT00000029807.1	ENSFCAP00000025067.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	94.70	0.00e+00	815.00	IUUC-Hsa-046376
E3 activity/RING/RING	79.44	0.00e+00	660.00	IUUC-Mmu-063207
E3 activity/RING/RING	81.84	0.00e+00	682.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Felis catus

Protein Sequence
(Fasta)

MCNTNMSVST DGAVSTSQMP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT 120

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Nucleotide Sequence
(Fasta)

ATGTGCAATA CCAACATGTC TGTGTCTACC GATGGTGCTG TAAGCACCTC ACAGATGCCA 60
GCTTCGGAAC AAGAGACCCT GGTTGGTATT TTTGTCTCAA GTGTGACTTT TAAGAATAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	96.95	0.00e+00	867.00
IUUC-Apl-003193	Anas platyrhynchos	64.43	5.00e-157	547.00
IUUC-Aca-004305	Anolis carolinensis	57.61	3.00e-121	428.00
IUUC-Ame-010675	Astyanax mexicanus	44.66	8.00e-83	300.00
IUUC-Bta-013270	Bos taurus	93.90	0.00e+00	812.00
IUUC-Cja-019744	Callithrix jacchus	91.89	0.00e+00	802.00
IUUC-Cfa-020807	Canis familiaris	95.38	0.00e+00	804.00
IUUC-Cpo-022182	Cavia porcellus	89.18	0.00e+00	757.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	9.00e-06	41.20
IUUC-Csa-023541	Chlorocebus sabaeus	94.30	0.00e+00	813.00
IUUC-Cho-024831	Choloepus hoffmanni	75.74	4.00e-88	317.00
IUUC-Csv-026151	Ciona savignyi	31.17	3.00e-11	62.00
IUUC-Dre-028419	Danio rerio	43.28	6.00e-50	191.00
IUUC-Dno-028950	Dasypus novemcinctus	92.87	0.00e+00	817.00
IUUC-Dor-031048	Dipodomys ordii	71.34	2.00e-172	598.00
IUUC-Ete-032264	Echinops telfairi	69.17	2.00e-174	605.00
IUUC-Eca-033301	Equus caballus	83.50	0.00e+00	726.00
IUUC-Eeu-035005	Erinaceus europaeus	82.69	0.00e+00	676.00
IUUC-Fal-036720	Ficedula albicollis	61.46	3.00e-73	268.00
IUUC-Gmo-039296	Gadus morhua	42.91	3.00e-46	178.00
IUUC-Gga-040251	Gallus gallus	65.24	3.00e-152	531.00
IUUC-Gac-041528	Gasterosteus aculeatus	40.00	6.00e-34	138.00
IUUC-Ggo-044948	Gorilla gorilla	86.35	0.00e+00	738.00
IUUC-Hsa-046376	Homo sapiens	94.70	0.00e+00	818.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	91.46	0.00e+00	770.00
IUUC-Lch-050037	Latimeria chalumnae	56.62	7.00e-118	417.00
IUUC-Loc-051837	Lepisosteus oculatus	50.51	3.00e-113	402.00
IUUC-Laf-053483	Loxodonta africana	86.18	0.00e+00	748.00
IUUC-Mcc-055294	Macaca mulatta	94.50	0.00e+00	816.00
IUUC-Mga-060007	Meleagris gallopavo	64.46	3.00e-146	511.00
IUUC-Mmr-060673	Microcebus murinus	93.89	0.00e+00	836.00
IUUC-Mdo-063057	Monodelphis domestica	75.61	0.00e+00	674.00
IUUC-Mmu-063207	Mus musculus	79.44	0.00e+00	635.00
IUUC-Mpu-065836	Mustela putorius furo	96.13	0.00e+00	865.00
IUUC-Mlu-068193	Myotis lucifugus	89.45	0.00e+00	801.00
IUUC-Nle-069927	Nomascus leucogenys	94.30	0.00e+00	815.00
IUUC-Opr-070590	Ochotona princeps	84.90	0.00e+00	716.00
IUUC-Ont-071984	Oreochromis niloticus	41.35	6.00e-51	194.00
IUUC-Oan-072744	Ornithorhynchus anatinus	71.49	4.00e-165	573.00
IUUC-Ocu-074071	Oryctolagus cuniculus	92.89	0.00e+00	803.00
IUUC-Ola-087329	Oryzias latipes	39.34	3.00e-67	249.00
IUUC-Oga-088135	Otolemur garnettii	83.43	0.00e+00	746.00
IUUC-Oar-090078	Ovis aries	93.48	0.00e+00	841.00
IUUC-Ptr-091399	Pan troglodytes	94.70	0.00e+00	819.00
IUUC-Pan-092720	Papio anubis	94.50	0.00e+00	816.00
IUUC-Psi-093591	Pelodiscus sinensis	65.43	9.00e-131	460.00
IUUC-Pfo-096316	Poecilia formosa	41.53	1.00e-71	263.00
IUUC-Pab-097696	Pongo abelii	93.89	0.00e+00	806.00
IUUC-Pca-100974	Procavia capensis	82.93	0.00e+00	762.00
IUUC-Pva-102488	Pteropus vampyrus	89.21	0.00e+00	731.00
IUUC-Rno-105641	Rattus norvegicus	81.84	0.00e+00	672.00
IUUC-Sha-107314	Sarcophilus harrisii	72.93	0.00e+00	686.00
IUUC-Sar-112938	Sorex araneus	86.53	0.00e+00	774.00
IUUC-Ssc-115495	Sus scrofa	94.70	0.00e+00	809.00
IUUC-Tgu-116623	Taeniopygia guttata	63.56	1.00e-149	522.00
IUUC-Tru-117820	Takifugu rubripes	39.09	3.00e-47	182.00
IUUC-Tsy-119162	Tarsius syrichta	67.93	6.00e-93	333.00
IUUC-Tni-119793	Tetraodon nigroviridis	41.57	1.00e-43	170.00
IUUC-Tbe-127816	Tupaia belangeri	90.31	2.00e-122	432.00
IUUC-Ttr-129194	Tursiops truncatus	83.63	0.00e+00	678.00
IUUC-Vpa-130326	Vicugna pacos	89.41	0.00e+00	756.00
IUUC-Xtr-132216	Xenopus tropicalis	56.18	1.00e-118	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence