iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062054

Ensembl Protein ID

ENSMODP00000025804.3

UniProt Accession

F7EN79; F7EN79_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

TEC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000020628.3	ENSMODT00000026265.3	ENSMODP00000025804.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-10	40.4	197	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++e v ++yd++a+++ +L+l++G    ++  e++d  W+++ ++ +g +G +P+n+v+
   Q: 197  NEEIVVAMYDFQATETHDLKLERGQEYIIL--EKNDVHWWRA-RDKHGSEGYIPSNYVT 252
           6789*********************99999..99********.5*************96 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEDWIFNGRK KKSNQMTEMN HNILLEEILI KRSQQKKKTS PLNYKERLFV LTKSLLSYYE 60
GRAEKKYRKG FIDISKIKCV EIVKIDDGII PCQNKFPFQV VHDSITLYIF APSAQSRDRW 120

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Nucleotide Sequence
(Fasta)

AGGAAAACTC AGAGACCGGC TTCAGCCGCG CAGCAATTGC GCAAAGCTGC CCCAGACTCG 60
GAGCGCTGAA GCCCATTGTG CCCCTGGCCG CAGCCCGAGG AGACGCAAGA GGTGGCAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0010543--P:regulation of platelet activation
GO:0042246--P:tissue regeneration
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003669	Anas platyrhynchos	75.82	0.00e+00	999.00
IUUC-Ame-010694	Astyanax mexicanus	60.31	9.00e-165	573.00
IUUC-Dre-028544	Danio rerio	68.32	8.00e-166	576.00
IUUC-Fal-036771	Ficedula albicollis	79.40	0.00e+00	1037.00
IUUC-Gac-042383	Gasterosteus aculeatus	54.51	7.00e-141	493.00
IUUC-Lch-050516	Latimeria chalumnae	73.61	0.00e+00	971.00
IUUC-Loc-052730	Lepisosteus oculatus	66.74	0.00e+00	641.00
IUUC-Mga-060196	Meleagris gallopavo	75.95	0.00e+00	993.00
IUUC-Mpu-066786	Mustela putorius furo	90.49	0.00e+00	1132.00
IUUC-Ont-072585	Oreochromis niloticus	68.85	0.00e+00	629.00
IUUC-Ola-086938	Oryzias latipes	67.81	2.00e-176	612.00
IUUC-Psi-093565	Pelodiscus sinensis	81.62	0.00e+00	1067.00
IUUC-Pfo-096955	Poecilia formosa	68.03	0.00e+00	635.00
IUUC-Tgu-116458	Taeniopygia guttata	80.51	0.00e+00	1060.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence