iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091900

Ensembl Protein ID

ENSPANP00000010390.1

UniProt Accession

A0A096NC59; A0A096NC59_PAPAN

Genbank Protein ID

ENSPANP00000010390

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AHZZ01070582

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000002013.1	ENSPANT00000009978.1	ENSPANP00000010390.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.10e-14	51.4	216	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ n ++L+l+kGd  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 216  LKKVVALYDYMPMNANDLQLRKGDEYFIL--EESNLPWWRA-RDKNGQEGYIPSNYVTEAE 273
           689*************************9..9999******.6***************987 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGCAGCAG GGAACCAGAT AGCATGCTGC TGAGAAGAAA AAAAGACATT GGTTTAGGTC 60
AGGAAACAAA AAAAGGGAAC TGAGTGGCTG TGAAAGGGTG GGGTTTGCTC AGACTGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	96.05	0.00e+00	1237.00
IUUC-Apl-003907	Anas platyrhynchos	83.97	0.00e+00	1087.00
IUUC-Aca-004978	Anolis carolinensis	74.28	0.00e+00	1015.00
IUUC-Ame-010694	Astyanax mexicanus	53.73	6.00e-143	500.00
IUUC-Bta-012467	Bos taurus	95.60	0.00e+00	1232.00
IUUC-Cja-018841	Callithrix jacchus	95.75	0.00e+00	1232.00
IUUC-Cfa-020983	Canis familiaris	95.90	0.00e+00	1222.00
IUUC-Cpo-021307	Cavia porcellus	95.75	0.00e+00	1236.00
IUUC-Csa-023508	Chlorocebus sabaeus	95.98	0.00e+00	932.00
IUUC-Dre-028544	Danio rerio	56.22	8.00e-140	489.00
IUUC-Dno-029828	Dasypus novemcinctus	94.08	0.00e+00	1204.00
IUUC-Dor-030102	Dipodomys ordii	87.91	0.00e+00	1014.00
IUUC-Ete-032981	Echinops telfairi	87.10	0.00e+00	1097.00
IUUC-Eca-033594	Equus caballus	96.36	0.00e+00	1240.00
IUUC-Eeu-035281	Erinaceus europaeus	93.74	0.00e+00	1011.00
IUUC-Fca-035495	Felis catus	95.45	0.00e+00	1216.00
IUUC-Fal-036719	Ficedula albicollis	83.31	0.00e+00	1113.00
IUUC-Gga-041193	Gallus gallus	83.16	0.00e+00	1085.00
IUUC-Gac-042383	Gasterosteus aculeatus	44.29	1.00e-118	420.00
IUUC-Hsa-045931	Homo sapiens	96.97	0.00e+00	1239.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	95.90	0.00e+00	1236.00
IUUC-Lch-049868	Latimeria chalumnae	72.19	0.00e+00	947.00
IUUC-Loc-052730	Lepisosteus oculatus	55.51	2.00e-154	539.00
IUUC-Laf-053516	Loxodonta africana	95.16	0.00e+00	1254.00
IUUC-Mcc-054795	Macaca mulatta	96.97	0.00e+00	1240.00
IUUC-Meu-056157	Macropus eugenii	82.09	0.00e+00	1051.00
IUUC-Mga-059529	Meleagris gallopavo	82.55	0.00e+00	916.00
IUUC-Mmr-060824	Microcebus murinus	91.65	0.00e+00	1150.00
IUUC-Mdo-063036	Monodelphis domestica	91.86	0.00e+00	1187.00
IUUC-Mmu-064047	Mus musculus	95.45	0.00e+00	1236.00
IUUC-Mpu-066810	Mustela putorius furo	95.75	0.00e+00	1236.00
IUUC-Mlu-067671	Myotis lucifugus	95.02	0.00e+00	1227.00
IUUC-Nle-069108	Nomascus leucogenys	96.97	0.00e+00	1241.00
IUUC-Opr-070505	Ochotona princeps	97.85	2.00e-109	389.00
IUUC-Ont-072585	Oreochromis niloticus	56.79	2.00e-152	532.00
IUUC-Oan-073495	Ornithorhynchus anatinus	90.29	0.00e+00	1198.00
IUUC-Ocu-074416	Oryctolagus cuniculus	95.90	0.00e+00	1236.00
IUUC-Ola-086938	Oryzias latipes	57.67	1.00e-148	519.00
IUUC-Oga-088995	Otolemur garnettii	94.56	0.00e+00	1216.00
IUUC-Oar-089632	Ovis aries	94.54	0.00e+00	1206.00
IUUC-Ptr-090941	Pan troglodytes	96.81	0.00e+00	1240.00
IUUC-Psi-093048	Pelodiscus sinensis	79.11	0.00e+00	1061.00
IUUC-Pfo-096955	Poecilia formosa	58.66	5.00e-156	544.00
IUUC-Pab-097587	Pongo abelii	96.81	0.00e+00	1241.00
IUUC-Pca-100374	Procavia capensis	88.93	2.00e-147	516.00
IUUC-Pva-102583	Pteropus vampyrus	95.75	0.00e+00	1210.00
IUUC-Rno-104868	Rattus norvegicus	90.79	0.00e+00	1152.00
IUUC-Sha-106744	Sarcophilus harrisii	90.59	0.00e+00	1209.00
IUUC-Sar-113041	Sorex araneus	95.08	0.00e+00	1078.00
IUUC-Ssc-115294	Sus scrofa	96.05	0.00e+00	1237.00
IUUC-Tgu-116458	Taeniopygia guttata	51.73	0.00e+00	686.00
IUUC-Tsy-118945	Tarsius syrichta	92.96	0.00e+00	818.00
IUUC-Ttr-128769	Tursiops truncatus	86.34	0.00e+00	1098.00
IUUC-Vpa-130517	Vicugna pacos	91.71	0.00e+00	667.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence