iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054187

UUCD1 version

UUC-LoA-01059

Ensembl Protein ID

ENSLAFP00000005317.1

UniProt Accession

G3SXZ4; G3SXZ4_LOXAF

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006332.1	ENSLAFT00000006332.1	ENSLAFP00000005317.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.70e-169	564.1	3	729

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d++i++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDEIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeeskpassksppvleasrapaasegthtdgaeevagscppapthsppskpklvvkppgsnlngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  ptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddeeddmqnassairykrkgpgkpgplsgsadgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktssgagspavavathsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspsirlsqssqgssspeekevaeaadsrektglv 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkrk 359
           +grl+kqrk++r+k++rp+k+kr+
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKRQ 729
           **********************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDEIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATAAGG GCTGGCTGGA GCTAGAGAGC GACCCGGGTG AGAAGGGGGT TGGGCGGGCC 60
GGGGGCTAGG GGGGCCACGG GTGGGCCCAT GGGCCAGGCA CACGTCCGCG GGAACGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100661537

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	94.16	0.00e+00	1214.00
IUUC-Apl-003405	Anas platyrhynchos	70.17	0.00e+00	635.00
IUUC-Aca-004836	Anolis carolinensis	80.49	0.00e+00	1157.00
IUUC-Ame-011946	Astyanax mexicanus	63.37	0.00e+00	891.00
IUUC-Bta-013131	Bos taurus	92.71	0.00e+00	1084.00
IUUC-Cja-019599	Callithrix jacchus	96.84	0.00e+00	1327.00
IUUC-Cfa-021003	Canis familiaris	96.30	0.00e+00	1217.00
IUUC-Cpo-022143	Cavia porcellus	95.61	0.00e+00	1296.00
IUUC-Csa-023477	Chlorocebus sabaeus	96.43	0.00e+00	1297.00
IUUC-Cho-024734	Choloepus hoffmanni	84.57	0.00e+00	773.00
IUUC-Csv-025842	Ciona savignyi	58.22	2.00e-94	339.00
IUUC-Dre-027793	Danio rerio	66.54	0.00e+00	911.00
IUUC-Dno-029253	Dasypus novemcinctus	95.96	0.00e+00	1283.00
IUUC-Dor-030891	Dipodomys ordii	89.44	0.00e+00	1204.00
IUUC-Dme-031796	Drosophila melanogaster	61.57	6.00e-93	334.00
IUUC-Ete-032646	Echinops telfairi	87.60	3.00e-171	595.00
IUUC-Eca-033805	Equus caballus	95.61	0.00e+00	1264.00
IUUC-Eeu-035216	Erinaceus europaeus	93.88	4.00e-148	518.00
IUUC-Fca-035611	Felis catus	95.82	0.00e+00	1164.00
IUUC-Fal-037186	Ficedula albicollis	81.57	0.00e+00	1005.00
IUUC-Gmo-038824	Gadus morhua	69.44	0.00e+00	630.00
IUUC-Gga-040875	Gallus gallus	82.05	0.00e+00	1123.00
IUUC-Gac-042226	Gasterosteus aculeatus	68.79	0.00e+00	945.00
IUUC-Ggo-045122	Gorilla gorilla	96.02	0.00e+00	1325.00
IUUC-Hsa-045882	Homo sapiens	96.02	0.00e+00	1325.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	96.98	0.00e+00	1306.00
IUUC-Lch-049960	Latimeria chalumnae	72.76	0.00e+00	1008.00
IUUC-Loc-052408	Lepisosteus oculatus	75.32	0.00e+00	659.00
IUUC-Mcc-055273	Macaca mulatta	95.47	0.00e+00	1288.00
IUUC-Meu-056267	Macropus eugenii	83.40	0.00e+00	1170.00
IUUC-Mga-059958	Meleagris gallopavo	88.24	1.00e-154	538.00
IUUC-Mmr-061280	Microcebus murinus	96.30	0.00e+00	1274.00
IUUC-Mdo-062625	Monodelphis domestica	90.12	0.00e+00	1284.00
IUUC-Mmu-063853	Mus musculus	93.00	0.00e+00	1267.00
IUUC-Mlu-067771	Myotis lucifugus	95.06	0.00e+00	1242.00
IUUC-Opr-070741	Ochotona princeps	93.83	0.00e+00	1285.00
IUUC-Ont-072172	Oreochromis niloticus	67.50	0.00e+00	947.00
IUUC-Oan-073167	Ornithorhynchus anatinus	80.25	0.00e+00	1142.00
IUUC-Ocu-074176	Oryctolagus cuniculus	95.32	0.00e+00	1233.00
IUUC-Ola-087203	Oryzias latipes	85.61	2.00e-135	474.00
IUUC-Oga-089153	Otolemur garnettii	95.43	0.00e+00	1278.00
IUUC-Oar-090008	Ovis aries	93.42	0.00e+00	1246.00
IUUC-Ptr-091234	Pan troglodytes	96.30	0.00e+00	1328.00
IUUC-Pan-092005	Papio anubis	96.57	0.00e+00	1319.00
IUUC-Psi-093995	Pelodiscus sinensis	84.46	0.00e+00	661.00
IUUC-Pma-094110	Petromyzon marinus	47.24	9.00e-120	423.00
IUUC-Pfo-097418	Poecilia formosa	65.62	0.00e+00	930.00
IUUC-Pab-098267	Pongo abelii	96.16	0.00e+00	1303.00
IUUC-Pca-101084	Procavia capensis	96.06	0.00e+00	1233.00
IUUC-Pva-102292	Pteropus vampyrus	95.92	0.00e+00	909.00
IUUC-Rno-105251	Rattus norvegicus	92.05	0.00e+00	1247.00
IUUC-Sha-107100	Sarcophilus harrisii	88.75	0.00e+00	1274.00
IUUC-Sar-113559	Sorex araneus	87.21	0.00e+00	1071.00
IUUC-Ssc-115688	Sus scrofa	95.75	0.00e+00	1290.00
IUUC-Tgu-117424	Taeniopygia guttata	80.33	0.00e+00	1127.00
IUUC-Tru-118585	Takifugu rubripes	67.84	0.00e+00	936.00
IUUC-Tsy-119299	Tarsius syrichta	85.02	0.00e+00	974.00
IUUC-Tni-120808	Tetraodon nigroviridis	67.56	0.00e+00	929.00
IUUC-Tbe-127705	Tupaia belangeri	96.51	0.00e+00	640.00
IUUC-Ttr-128225	Tursiops truncatus	95.20	0.00e+00	1246.00
IUUC-Vpa-130193	Vicugna pacos	94.58	3.00e-129	455.00
IUUC-Xtr-132449	Xenopus tropicalis	71.31	0.00e+00	946.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence