iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059271

UUCD1 version

UUC-MeG-00673

Ensembl Protein ID

ENSMGAP00000015653.2

UniProt Accession

G1NPJ3; G1NPJ3_MELGA

Protein Name

Uncharacterized protein

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014772.2	ENSMGAT00000016612.2	ENSMGAP00000015653.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-108	362.6	552	878

Active Site

Position(s)	Description	Evidence
847	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 552  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 635
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+sl  ++e+ e ++e+  + +tf+  +++++g+   ++Lk++G++ip+tneN++e+v+l++
   Q: 636  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLRDLLEY-EGSVEDD-MMITFQiSHTDLFGNPMMHDLKENGDKIPITNENRKEFVNLYA 722
           *************************************.6677775.999999445566******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 723  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSLIIREFWEIVHSFTDEQKRLFLQ 811
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 812  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 878
           *****************...8888866666**************************************97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MSFVCESSTN PWTYCLNVCY RKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM 60
DNNAAAIKAL ELYKINAKLC DPHPSKKGTS SAYLENNSKG AHNNSCTDRK MNKKEMQGPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTTTG TATGTGAAAG CTCTACTAAT CCTTGGACTT ACTGTTTGAA TGTTTGCTAC 60
AGGAAGCGAG CAGCTGCAAA GCATCTAATA GAGCGCTACT ACCACCAGTT AACTGAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	93.87	0.00e+00	1597.00
IUUC-Atr-003144	Amborella trichopoda	45.80	7.00e-97	347.00
IUUC-Apl-003742	Anas platyrhynchos	97.84	0.00e+00	1649.00
IUUC-Aca-004873	Anolis carolinensis	95.36	0.00e+00	1643.00
IUUC-Ame-011166	Astyanax mexicanus	86.50	0.00e+00	1465.00
IUUC-Bta-013286	Bos taurus	92.27	0.00e+00	1520.00
IUUC-Cja-019707	Callithrix jacchus	90.50	0.00e+00	1562.00
IUUC-Cfa-020154	Canis familiaris	94.06	0.00e+00	1556.00
IUUC-Cpo-021292	Cavia porcellus	93.13	0.00e+00	1551.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	5.00e-82	297.00
IUUC-Csa-023378	Chlorocebus sabaeus	90.10	0.00e+00	1565.00
IUUC-Cho-025059	Choloepus hoffmanni	91.04	0.00e+00	1493.00
IUUC-Cin-025643	Ciona intestinalis	44.20	0.00e+00	708.00
IUUC-Csv-026282	Ciona savignyi	44.53	0.00e+00	667.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.24	8.00e-102	365.00
IUUC-Dre-027901	Danio rerio	85.56	0.00e+00	1443.00
IUUC-Dno-029320	Dasypus novemcinctus	92.84	0.00e+00	1575.00
IUUC-Dor-030756	Dipodomys ordii	89.12	0.00e+00	706.00
IUUC-Dme-032035	Drosophila melanogaster	42.96	2.00e-165	576.00
IUUC-Eca-033843	Equus caballus	94.17	0.00e+00	1529.00
IUUC-Eeu-035109	Erinaceus europaeus	92.19	0.00e+00	1509.00
IUUC-Fca-036344	Felis catus	92.16	0.00e+00	1561.00
IUUC-Fal-036747	Ficedula albicollis	97.73	0.00e+00	1648.00
IUUC-Fox-037941	Fusarium oxysporum	33.08	1.00e-91	331.00
IUUC-Gmo-038840	Gadus morhua	63.88	0.00e+00	1109.00
IUUC-Gga-040399	Gallus gallus	97.73	0.00e+00	1649.00
IUUC-Gac-041933	Gasterosteus aculeatus	86.73	0.00e+00	1400.00
IUUC-Ggo-044804	Gorilla gorilla	90.71	0.00e+00	1561.00
IUUC-Hsa-045727	Homo sapiens	90.71	0.00e+00	1561.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	90.34	0.00e+00	1470.00
IUUC-Lch-050197	Latimeria chalumnae	92.07	0.00e+00	1551.00
IUUC-Loc-052743	Lepisosteus oculatus	91.27	0.00e+00	1537.00
IUUC-Lma-053245	Leptosphaeria maculans	35.11	8.00e-58	219.00
IUUC-Laf-053615	Loxodonta africana	94.53	0.00e+00	1583.00
IUUC-Mcc-054934	Macaca mulatta	90.60	0.00e+00	1559.00
IUUC-Meu-056061	Macropus eugenii	96.56	0.00e+00	1363.00
IUUC-Mmr-061288	Microcebus murinus	93.94	0.00e+00	1560.00
IUUC-Mdo-062975	Monodelphis domestica	95.01	0.00e+00	1616.00
IUUC-Mmu-063674	Mus musculus	90.09	0.00e+00	1510.00
IUUC-Mpu-066568	Mustela putorius furo	92.84	0.00e+00	1576.00
IUUC-Mlu-067522	Myotis lucifugus	84.76	0.00e+00	1437.00
IUUC-Nle-069505	Nomascus leucogenys	90.71	0.00e+00	1561.00
IUUC-Opr-070570	Ochotona princeps	87.44	0.00e+00	1421.00
IUUC-Ont-071527	Oreochromis niloticus	86.61	0.00e+00	1478.00
IUUC-Oan-073446	Ornithorhynchus anatinus	87.71	0.00e+00	1033.00
IUUC-Ocu-074922	Oryctolagus cuniculus	91.52	0.00e+00	1560.00
IUUC-Ola-086996	Oryzias latipes	86.00	0.00e+00	1476.00
IUUC-Oga-088261	Otolemur garnettii	94.17	0.00e+00	1562.00
IUUC-Oar-090024	Ovis aries	92.27	0.00e+00	1520.00
IUUC-Ptr-090455	Pan troglodytes	90.71	0.00e+00	1561.00
IUUC-Pan-092509	Papio anubis	93.39	0.00e+00	1403.00
IUUC-Psi-092974	Pelodiscus sinensis	94.89	0.00e+00	1597.00
IUUC-Pma-094643	Petromyzon marinus	71.36	0.00e+00	1254.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	5.00e-59	223.00
IUUC-Ppa-095354	Physcomitrella patens	46.61	5.00e-111	395.00
IUUC-Pfo-096905	Poecilia formosa	86.03	0.00e+00	1461.00
IUUC-Pab-097840	Pongo abelii	91.26	0.00e+00	1519.00
IUUC-Pca-100869	Procavia capensis	93.83	0.00e+00	1573.00
IUUC-Pva-103040	Pteropus vampyrus	95.83	0.00e+00	659.00
IUUC-Rno-105453	Rattus norvegicus	89.74	0.00e+00	1506.00
IUUC-Sha-107651	Sarcophilus harrisii	95.01	0.00e+00	1616.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	2.00e-115	409.00
IUUC-Sar-113293	Sorex araneus	94.17	0.00e+00	1560.00
IUUC-Ssc-115979	Sus scrofa	94.29	0.00e+00	1560.00
IUUC-Tgu-116901	Taeniopygia guttata	97.73	0.00e+00	1647.00
IUUC-Tru-118368	Takifugu rubripes	86.71	0.00e+00	1464.00
IUUC-Tsy-119516	Tarsius syrichta	90.21	0.00e+00	1455.00
IUUC-Tni-120143	Tetraodon nigroviridis	86.71	0.00e+00	1459.00
IUUC-Tbe-127484	Tupaia belangeri	88.58	0.00e+00	1066.00
IUUC-Ttr-129078	Tursiops truncatus	93.94	0.00e+00	1530.00
IUUC-Vpa-130312	Vicugna pacos	86.31	0.00e+00	1311.00
IUUC-Xtr-132881	Xenopus tropicalis	89.81	0.00e+00	1574.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence