iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088284

Ensembl Protein ID

ENSOGAP00000007819.2

UniProt Accession

H0WZ31; H0WZ31_OTOGA

Genbank Protein ID

ENSOGAP00000007819

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03122392

Gene Name

STRN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000008717.2	ENSOGAT00000008724.2	ENSOGAP00000007819.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-29	100.8	567	599
UBD/Beta-Prp	3.40e-45	154.5	563	777

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHtd v++la+   +  +l+s+s Dgt+++W+++
   Q: 567  GHTDAVWGLAYsaaH-QRLLSCSADGTLRLWNTT 599
           8**********9853.89**************76 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk......ghedsvlslsfspsgdklvsGshdrtirvwdletgqc 128
             l gh+++v+ + +s   + l+++s D+t+++w+     +  ++       g  +sv ++s++p  +++v+  +  +  ++++et+q 
   Q: 563  GPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFndnqelGIPASVDLVSSDP--SHMVASFSKGYTSIFNMETQQR 649
           5689******************************8887766666661444444444555566666..8888888899************ PP
   S: 129  lee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqt 211
           + +      t +  +  +n v +hp+  + ++++ Dr ++++d +tgkl++ +   h ++v+sl++d+ng +l+sgs+d +++lw+l++
   Q: 650  ILTlesnldTSTSFSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVA-HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
           **999987777777778899999**99**************************98.********************************* PP
   S: 212  gecvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           ++c++++++h+    + + +v+f+p + +++s+++D   +
   Q: 738  KTCIQEFTAHRkkfeESIHDVAFHPSKCYIASAGADALAK 777
           ***********999999******************97655 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAVGDGAAAT GAARAQYSLP GILHFLQHEW 60
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCCGCCA TGGACGAGCA GGCGGGTCCT GGCGTCTTCT TCAGCAACAA CCACCCAGGC 60
GCCGGCGGTG CCAAGGGGCT CGGGCCTCTG GCAGAGGCTG CCGCGGTCGG CGACGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0000159--C:protein phosphatase type 2A complex
GO:0008285--P:negative regulation of cell proliferation
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001899	Ailuropoda melanoleuca	97.96	0.00e+00	1375.00
IUUC-Apl-003927	Anas platyrhynchos	87.80	0.00e+00	1123.00
IUUC-Aca-004933	Anolis carolinensis	80.89	0.00e+00	1144.00
IUUC-Ame-010997	Astyanax mexicanus	73.78	0.00e+00	1079.00
IUUC-Bta-013077	Bos taurus	97.05	0.00e+00	1377.00
IUUC-Cja-018973	Callithrix jacchus	97.95	0.00e+00	1386.00
IUUC-Cfa-020988	Canis familiaris	94.59	0.00e+00	1252.00
IUUC-Cpo-022496	Cavia porcellus	97.05	0.00e+00	1377.00
IUUC-Csa-023829	Chlorocebus sabaeus	96.93	0.00e+00	1375.00
IUUC-Dre-028560	Danio rerio	69.30	0.00e+00	979.00
IUUC-Dno-029742	Dasypus novemcinctus	91.67	0.00e+00	1313.00
IUUC-Dor-030721	Dipodomys ordii	88.59	0.00e+00	1243.00
IUUC-Eca-033760	Equus caballus	97.58	0.00e+00	1281.00
IUUC-Eeu-034953	Erinaceus europaeus	96.61	0.00e+00	749.00
IUUC-Fca-036530	Felis catus	97.44	0.00e+00	1307.00
IUUC-Fal-037353	Ficedula albicollis	81.49	0.00e+00	897.00
IUUC-Gga-040132	Gallus gallus	87.89	0.00e+00	1139.00
IUUC-Gac-041713	Gasterosteus aculeatus	73.33	0.00e+00	1059.00
IUUC-Ggo-045455	Gorilla gorilla	85.59	0.00e+00	1177.00
IUUC-Hsa-046415	Homo sapiens	97.56	0.00e+00	1381.00
IUUC-Lch-050475	Latimeria chalumnae	81.77	0.00e+00	1214.00
IUUC-Loc-051859	Lepisosteus oculatus	77.85	0.00e+00	1152.00
IUUC-Laf-053537	Loxodonta africana	96.92	0.00e+00	1399.00
IUUC-Mcc-055817	Macaca mulatta	96.68	0.00e+00	1375.00
IUUC-Meu-055946	Macropus eugenii	69.40	0.00e+00	909.00
IUUC-Mga-059694	Meleagris gallopavo	88.07	0.00e+00	1118.00
IUUC-Mmr-060768	Microcebus murinus	98.59	0.00e+00	1414.00
IUUC-Mdo-061901	Monodelphis domestica	86.31	0.00e+00	1313.00
IUUC-Mmu-064154	Mus musculus	96.03	0.00e+00	1365.00
IUUC-Mpu-065827	Mustela putorius furo	92.95	0.00e+00	1391.00
IUUC-Mlu-067102	Myotis lucifugus	97.01	0.00e+00	1347.00
IUUC-Ncr-068831	Neurospora crassa	39.60	6.00e-22	99.80
IUUC-Nle-070008	Nomascus leucogenys	97.58	0.00e+00	1287.00
IUUC-Opr-071067	Ochotona princeps	61.00	2.00e-177	615.00
IUUC-Ont-072025	Oreochromis niloticus	73.16	0.00e+00	1058.00
IUUC-Oan-072950	Ornithorhynchus anatinus	91.62	0.00e+00	1154.00
IUUC-Ocu-074316	Oryctolagus cuniculus	96.44	0.00e+00	1264.00
IUUC-Ola-087279	Oryzias latipes	71.07	0.00e+00	1031.00
IUUC-Oar-090304	Ovis aries	97.56	0.00e+00	1383.00
IUUC-Ptr-091052	Pan troglodytes	97.69	0.00e+00	1382.00
IUUC-Pan-092270	Papio anubis	91.82	0.00e+00	1328.00
IUUC-Psi-093907	Pelodiscus sinensis	87.59	0.00e+00	1038.00
IUUC-Pfo-097042	Poecilia formosa	71.93	0.00e+00	1137.00
IUUC-Pab-098110	Pongo abelii	97.69	0.00e+00	1382.00
IUUC-Pca-100266	Procavia capensis	85.08	0.00e+00	989.00
IUUC-Pva-102824	Pteropus vampyrus	95.38	0.00e+00	1361.00
IUUC-Pgr-103483	Puccinia graminis	36.99	3.00e-56	214.00
IUUC-Rno-105638	Rattus norvegicus	96.03	0.00e+00	1371.00
IUUC-Sha-107004	Sarcophilus harrisii	87.69	0.00e+00	1125.00
IUUC-Ssc-115280	Sus scrofa	98.33	0.00e+00	1396.00
IUUC-Tgu-116759	Taeniopygia guttata	88.35	0.00e+00	1143.00
IUUC-Tru-117944	Takifugu rubripes	73.16	0.00e+00	1056.00
IUUC-Tsy-119405	Tarsius syrichta	86.04	0.00e+00	1078.00
IUUC-Tni-120571	Tetraodon nigroviridis	72.60	0.00e+00	1062.00
IUUC-Vpa-130294	Vicugna pacos	97.01	0.00e+00	1271.00
IUUC-Xma-134233	Xiphophorus maculatus	68.10	0.00e+00	909.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence