iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088586

Ensembl Protein ID

ENSOGAP00000011271.2

UniProt Accession

H0X794; H0X794_OTOGA

Genbank Protein ID

ENSOGAP00000011271

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AAQR03140262

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000012580.2	ENSOGAT00000012585.2	ENSOGAP00000011271.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	91.81	0.00e+00	994.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMAMLHQIQG NELEPLNRPQ LKIPLERPLG EVYVDSSKPA VYNYPEGAAY 60
EFNAAAAASA PVYGQSGLPY GPGSEAAAFG ANGLGSFSQL NSVSPSPLVL LHPPPQLSPF 120

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Nucleotide Sequence
(Fasta)

ATGACCATGA CCCTCCACAC CAAAGCCTCC GGAATGGCCA TGCTGCACCA GATCCAAGGG 60
AACGAGCTGG AGCCCCTGAA CCGCCCTCAG CTCAAGATCC CCCTGGAGCG GCCCCTGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	92.22	0.00e+00	793.00
IUUC-Apl-003688	Anas platyrhynchos	79.48	0.00e+00	798.00
IUUC-Aca-005222	Anolis carolinensis	77.20	0.00e+00	862.00
IUUC-Ame-010731	Astyanax mexicanus	57.56	5.00e-137	481.00
IUUC-Bta-013112	Bos taurus	88.81	0.00e+00	938.00
IUUC-Cja-019408	Callithrix jacchus	92.31	0.00e+00	1006.00
IUUC-Cfa-020694	Canis familiaris	88.48	0.00e+00	937.00
IUUC-Cpo-021426	Cavia porcellus	86.48	0.00e+00	929.00
IUUC-Csa-023736	Chlorocebus sabaeus	92.24	0.00e+00	873.00
IUUC-Dre-027698	Danio rerio	55.96	9.00e-131	460.00
IUUC-Dno-029477	Dasypus novemcinctus	88.19	0.00e+00	745.00
IUUC-Dor-030572	Dipodomys ordii	89.69	0.00e+00	748.00
IUUC-Ete-032849	Echinops telfairi	71.03	0.00e+00	658.00
IUUC-Eca-033605	Equus caballus	87.12	0.00e+00	947.00
IUUC-Eeu-034683	Erinaceus europaeus	91.55	2.00e-109	389.00
IUUC-Fca-035928	Felis catus	91.33	0.00e+00	781.00
IUUC-Fal-036754	Ficedula albicollis	77.63	0.00e+00	880.00
IUUC-Gmo-038872	Gadus morhua	55.91	5.00e-110	391.00
IUUC-Gga-040988	Gallus gallus	78.30	0.00e+00	866.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.57	1.00e-123	436.00
IUUC-Ggo-044749	Gorilla gorilla	92.47	0.00e+00	1004.00
IUUC-Hsa-046944	Homo sapiens	91.81	0.00e+00	999.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	90.13	0.00e+00	970.00
IUUC-Loc-052414	Lepisosteus oculatus	58.20	0.00e+00	627.00
IUUC-Mcc-054781	Macaca mulatta	92.14	0.00e+00	1002.00
IUUC-Meu-056232	Macropus eugenii	85.95	0.00e+00	917.00
IUUC-Mga-059319	Meleagris gallopavo	78.80	0.00e+00	871.00
IUUC-Mmr-061636	Microcebus murinus	93.75	1.00e-176	612.00
IUUC-Mdo-062661	Monodelphis domestica	87.46	0.00e+00	936.00
IUUC-Mmu-063330	Mus musculus	89.37	0.00e+00	944.00
IUUC-Mpu-065757	Mustela putorius furo	91.67	0.00e+00	967.00
IUUC-Mlu-067712	Myotis lucifugus	89.67	0.00e+00	849.00
IUUC-Ncr-068935	Neurospora crassa	35.48	2.40e-01	30.80
IUUC-Nle-069283	Nomascus leucogenys	92.14	0.00e+00	969.00
IUUC-Opr-070391	Ochotona princeps	88.31	0.00e+00	986.00
IUUC-Ont-071369	Oreochromis niloticus	55.39	1.00e-118	420.00
IUUC-Oan-073734	Ornithorhynchus anatinus	73.12	2.00e-129	455.00
IUUC-Ocu-074292	Oryctolagus cuniculus	90.37	0.00e+00	975.00
IUUC-Oba-075103	Oryza barthii	28.21	6.00e-03	35.80
IUUC-Ogu-079042	Oryza glumaepatula	28.21	1.00e-03	38.10
IUUC-Olo-080944	Oryza longistaminata	28.21	3.00e-03	35.00
IUUC-Oni-082560	Oryza nivara	28.21	5.00e-03	35.80
IUUC-Ola-087052	Oryzias latipes	51.36	1.00e-127	450.00
IUUC-Oar-090156	Ovis aries	90.62	0.00e+00	820.00
IUUC-Ptr-091321	Pan troglodytes	92.31	0.00e+00	1004.00
IUUC-Pan-092851	Papio anubis	91.97	0.00e+00	1001.00
IUUC-Psi-093434	Pelodiscus sinensis	78.09	0.00e+00	907.00
IUUC-Pfo-097379	Poecilia formosa	55.81	2.00e-131	462.00
IUUC-Pab-097735	Pongo abelii	92.14	0.00e+00	1002.00
IUUC-Pva-102125	Pteropus vampyrus	88.13	0.00e+00	942.00
IUUC-Rno-106121	Rattus norvegicus	89.22	0.00e+00	943.00
IUUC-Sha-107547	Sarcophilus harrisii	87.46	0.00e+00	931.00
IUUC-Sar-113650	Sorex araneus	78.74	3.00e-176	611.00
IUUC-Tgu-117175	Taeniopygia guttata	78.38	0.00e+00	883.00
IUUC-Tru-117545	Takifugu rubripes	56.08	2.00e-134	473.00
IUUC-Tsy-119586	Tarsius syrichta	88.62	0.00e+00	740.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.79	2.00e-136	479.00
IUUC-Tbe-127548	Tupaia belangeri	82.06	0.00e+00	634.00
IUUC-Ttr-128374	Tursiops truncatus	86.62	0.00e+00	874.00
IUUC-Vpa-130464	Vicugna pacos	81.52	3.00e-153	534.00
IUUC-Xtr-132171	Xenopus tropicalis	69.90	0.00e+00	738.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence