iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050303

Ensembl Protein ID

ENSLACP00000011027.1

UniProt Accession

H3AN06; H3AN06_LATCH

Genbank Protein ID

ENSLACP00000011027

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01129035

Gene Name

CYLD

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000009704.1	ENSLACT00000011110.1	ENSLACP00000011027.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-17	62.9	593	952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + + k + e ++e++  l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPRTKNDVEYYSETQDLLRTEIVNPLRIYGyVCATKIMKLRRILEKVEAASGF--TSEE 679
           999***************************77777777788888889999999999888789***************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqikclec.dnvs.sreepfldlslp 175
           +D +Efl++l++++ +       k ++  ++ +++   ++  +k++k +  +i++l+++++  s++k  e    ++ + +  f+ +   
   Q: 680  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMDKDDKIGVPTIQQLLEWSFInSDLKFAEElSFNTiKHYGFFFCFVFF 766
           ****************99..88999999999999**************************98445665443033332444555555555 PP
   S: 176  vp.gkeetkkeslqdcL.esftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           ++  ++  k+++++  +  s  +e++++g  + y+c++c+++++ +   k+k+++++  ++            ++k++k+  + l  dl
   Q: 767  FQlFRNLLKMNKFSFFFsISAPRECRICGGLAlYECRECYNDTDITAG-KIKQFCKICNMQVHLH-------PQRKVHKYGALALPEDL 847
           553222233334444443355566777776666**********86665.99**999876665544.......33566666666666788 PP
   S: 262  spfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn................................ekgkWllfdDskVtevk 318
           + +  ++  +   ++k eL+av++ +      HYva+vk                                 e g++l+++ ++ +++ 
   Q: 848  EDYIWRQ--GFIPRQKMELFAVLCIET----SHYVAFVKYglddsawvffdsmadrdggqngfnipqvtpcpEVGEYLKMSPEELHTLA 930
           9999984..45569**********999....9********8855555555555555555555555555555444555555556666666 PP
   S: 319  eeevleetg...staYvlfYkr 337
            ++++ + +   ++aY+++Y++
   Q: 931  PKSIQGFARrllCDAYMCMYQS 952
           666666555***********95 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSSSLWSQDK TAFWEERKFA LLVQDCNATD KQNQKFVKIA KGSIAQLLQD RVLSRTVNVP 60
TSKSKKAQVR VKILDQPNTF LFIDEKDFIE IDEKQADLLL PITNHEERYT LFKNKPRLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTTTTCA AGGGTGTGTG TGTGTGTGTG TATGTTTTCC TGTTTAACTC AGCCGGAGAA 60
TCATGTCAGT GATATGGTGA GGCAGAGTAA TCAAGGAGGA AATGCGTGTG GGAGCTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:1990108--P:protein linear deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	71.10	0.00e+00	1404.00
IUUC-Apl-003356	Anas platyrhynchos	71.40	0.00e+00	1373.00
IUUC-Aca-004402	Anolis carolinensis	65.91	0.00e+00	1197.00
IUUC-Ame-011581	Astyanax mexicanus	65.16	0.00e+00	1189.00
IUUC-Bta-012359	Bos taurus	70.69	0.00e+00	1384.00
IUUC-Cja-018797	Callithrix jacchus	71.10	0.00e+00	1404.00
IUUC-Cfa-020264	Canis familiaris	70.90	0.00e+00	1391.00
IUUC-Cpo-022057	Cavia porcellus	70.79	0.00e+00	1397.00
IUUC-Csa-023093	Chlorocebus sabaeus	71.21	0.00e+00	1399.00
IUUC-Cho-024486	Choloepus hoffmanni	67.72	2.00e-117	416.00
IUUC-Dre-028233	Danio rerio	64.53	0.00e+00	1202.00
IUUC-Dno-029496	Dasypus novemcinctus	71.68	0.00e+00	1397.00
IUUC-Dor-030919	Dipodomys ordii	67.05	0.00e+00	1296.00
IUUC-Ete-032734	Echinops telfairi	72.00	0.00e+00	1102.00
IUUC-Eca-033350	Equus caballus	71.00	0.00e+00	1396.00
IUUC-Eeu-034566	Erinaceus europaeus	81.50	6.00e-87	315.00
IUUC-Fca-035632	Felis catus	69.84	0.00e+00	973.00
IUUC-Fal-037313	Ficedula albicollis	67.59	0.00e+00	1276.00
IUUC-Gmo-039239	Gadus morhua	65.57	0.00e+00	1181.00
IUUC-Gga-040668	Gallus gallus	70.78	0.00e+00	1368.00
IUUC-Gac-042630	Gasterosteus aculeatus	65.54	0.00e+00	1165.00
IUUC-Ggo-044462	Gorilla gorilla	70.90	0.00e+00	1399.00
IUUC-Hsa-045846	Homo sapiens	70.90	0.00e+00	1399.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	75.63	0.00e+00	666.00
IUUC-Loc-052190	Lepisosteus oculatus	66.46	0.00e+00	1186.00
IUUC-Laf-054480	Loxodonta africana	73.27	6.00e-170	590.00
IUUC-Mcc-055849	Macaca mulatta	71.10	0.00e+00	1403.00
IUUC-Meu-056755	Macropus eugenii	62.87	0.00e+00	659.00
IUUC-Mga-059561	Meleagris gallopavo	70.46	0.00e+00	1356.00
IUUC-Mmr-060942	Microcebus murinus	71.21	0.00e+00	1394.00
IUUC-Mdo-062618	Monodelphis domestica	70.79	0.00e+00	1392.00
IUUC-Mmu-063843	Mus musculus	70.28	0.00e+00	1335.00
IUUC-Mpu-066919	Mustela putorius furo	71.00	0.00e+00	1395.00
IUUC-Mlu-066983	Myotis lucifugus	69.45	0.00e+00	1341.00
IUUC-Nle-069893	Nomascus leucogenys	71.00	0.00e+00	1399.00
IUUC-Opr-071181	Ochotona princeps	66.70	0.00e+00	1211.00
IUUC-Ont-071697	Oreochromis niloticus	65.92	0.00e+00	1159.00
IUUC-Oan-073658	Ornithorhynchus anatinus	71.10	0.00e+00	1368.00
IUUC-Ocu-074954	Oryctolagus cuniculus	71.21	0.00e+00	1402.00
IUUC-Ola-086523	Oryzias latipes	65.13	0.00e+00	1128.00
IUUC-Oga-089003	Otolemur garnettii	71.31	0.00e+00	1406.00
IUUC-Oar-090376	Ovis aries	70.61	0.00e+00	1389.00
IUUC-Ptr-090520	Pan troglodytes	69.14	0.00e+00	1348.00
IUUC-Pan-092281	Papio anubis	71.21	0.00e+00	1399.00
IUUC-Psi-093047	Pelodiscus sinensis	73.73	0.00e+00	1320.00
IUUC-Pma-094575	Petromyzon marinus	54.17	2.00e-65	241.00
IUUC-Pfo-096358	Poecilia formosa	63.65	0.00e+00	1103.00
IUUC-Pab-097740	Pongo abelii	71.21	0.00e+00	1404.00
IUUC-Pca-100461	Procavia capensis	68.23	0.00e+00	931.00
IUUC-Pva-102134	Pteropus vampyrus	63.88	0.00e+00	1219.00
IUUC-Rno-105807	Rattus norvegicus	69.45	0.00e+00	1307.00
IUUC-Sha-107236	Sarcophilus harrisii	70.64	0.00e+00	1324.00
IUUC-Sar-113366	Sorex araneus	79.13	0.00e+00	751.00
IUUC-Tgu-117201	Taeniopygia guttata	71.86	0.00e+00	1374.00
IUUC-Tru-117953	Takifugu rubripes	64.79	0.00e+00	1154.00
IUUC-Tsy-119610	Tarsius syrichta	69.25	0.00e+00	1356.00
IUUC-Tbe-128155	Tupaia belangeri	68.05	4.00e-159	555.00
IUUC-Ttr-128942	Tursiops truncatus	65.74	0.00e+00	1278.00
IUUC-Vpa-130281	Vicugna pacos	66.00	0.00e+00	984.00
IUUC-Xtr-132627	Xenopus tropicalis	63.88	0.00e+00	1129.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence