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Tag Content
UUCD2 ID IUUC-Pab-097740
UUCD1 version UUC-PoA-01102
Ensembl Protein ID ENSPPYP00000008294.1
UniProt Accession H2NQV8; H2NQV8_PONAB
Genbank Protein ID ENSPPYP00000008294
Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD
Genbank Nucleotide ID ABGA01187172
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000007344.2 ENSPPYT00000033924.1 ENSPPYP00000024661.1
ENSPPYG00000007344.2 ENSPPYT00000008634.1 ENSPPYP00000008294.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.20e-24 87.2 593 949
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 679
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 680  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 766
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   +       +  + v++p+
   Q: 767  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 842
           ****99998...***************987655********9984433.55555553334688999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        +++ eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 843  DLpdwDWRHGCIP-------CQNMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 920
           6511144444554.......99*********999....9********777788*****9999*******99999999976678888776 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 921  edlhsldsrriqgcarrllCDAYMCMYQS 949
           899999999999999************85 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
MSSGLWSQDK VTSPYWEERV FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-097740|DUB,USP|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGAAAGTC CCTTCGGCCG GCGCCGGGCC GGCAGCCATT GGAGGAAGGT CTGTCACAGG 60
GAGGCCCAAT CACGGCCCGC TCAGAAGCGC AGCTCGGCCT ACGATTGGCT AGCGCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097740|DUB,USP|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000863 Aegilops tauschii 36.51 1.60e-01 29.60
IUUC-Aml-001298 Ailuropoda melanoleuca 96.55 0.00e+00 1915.00
IUUC-Atr-003043 Amborella trichopoda 30.14 2.60e-01 28.90
IUUC-Apl-003356 Anas platyrhynchos 87.04 0.00e+00 1687.00
IUUC-Aca-004402 Anolis carolinensis 80.79 0.00e+00 1515.00
IUUC-Aly-005916 Arabidopsis lyrata 36.54 2.40e-01 28.90
IUUC-Ath-007038 Arabidopsis thaliana 36.54 2.60e-01 28.90
IUUC-Acl-008216 Aspergillus clavatus 47.22 3.00e-04 38.50
IUUC-Afl-008534 Aspergillus flavus 32.56 5.00e-05 41.60
IUUC-Afu-008927 Aspergillus fumigatus 26.43 3.00e-04 38.90
IUUC-Ani-009283 Aspergillus nidulans 40.91 1.00e-03 37.00
IUUC-Ang-009564 Aspergillus niger 41.82 1.00e-04 40.40
IUUC-Aor-010034 Aspergillus oryzae 32.56 5.00e-05 41.60
IUUC-Ate-010424 Aspergillus terreus 43.40 2.00e-04 39.30
IUUC-Ame-011581 Astyanax mexicanus 67.74 0.00e+00 1222.00
IUUC-Bta-012359 Bos taurus 96.23 0.00e+00 1892.00
IUUC-Bci-013694 Botrytis cinerea 39.29 4.10e+00 25.00
IUUC-Bol-015891 Brassica oleracea 38.46 3.70e-02 31.60
IUUC-Bra-017389 Brassica rapa 38.46 9.00e-02 30.40
IUUC-Cel-018528 Caenorhabditis elegans 34.72 3.00e-55 211.00
IUUC-Cja-018797 Callithrix jacchus 98.43 0.00e+00 1950.00
IUUC-Cfa-020264 Canis familiaris 96.65 0.00e+00 1907.00
IUUC-Cpo-022057 Cavia porcellus 95.71 0.00e+00 1895.00
IUUC-Csa-023093 Chlorocebus sabaeus 98.95 0.00e+00 1951.00
IUUC-Cho-024486 Choloepus hoffmanni 82.32 8.00e-178 617.00
IUUC-Cin-025179 Ciona intestinalis 43.89 9.00e-116 410.00
IUUC-Csv-025811 Ciona savignyi 34.62 2.70e-02 32.00
IUUC-Cgl-026504 Colletotrichum gloeosporioides 30.93 2.50e-02 32.30
IUUC-Cne-026867 Cryptococcus neoformans 43.14 3.00e-05 42.00
IUUC-Cme-027227 Cyanidioschyzon merolae 36.36 5.00e-02 31.20
IUUC-Dre-028233 Danio rerio 67.04 0.00e+00 1255.00
IUUC-Dno-029496 Dasypus novemcinctus 95.61 0.00e+00 1889.00
IUUC-Dor-030919 Dipodomys ordii 89.96 0.00e+00 1754.00
IUUC-Dse-031240 Dothistroma septosporum 32.79 1.20e-02 33.10
IUUC-Dme-032159 Drosophila melanogaster 45.68 1.00e-124 440.00
IUUC-Ete-032734 Echinops telfairi 90.38 0.00e+00 1779.00
IUUC-Eca-033350 Equus caballus 96.65 0.00e+00 1909.00
IUUC-Eeu-034566 Erinaceus europaeus 98.39 2.00e-114 407.00
IUUC-Fca-035632 Felis catus 95.44 0.00e+00 1326.00
IUUC-Fal-037313 Ficedula albicollis 82.03 0.00e+00 1571.00
IUUC-Fox-037822 Fusarium oxysporum 34.67 3.00e-03 35.40
IUUC-Fso-038149 Fusarium solani 34.67 6.00e-03 34.30
IUUC-Gmo-039239 Gadus morhua 67.05 0.00e+00 1204.00
IUUC-Ggr-039751 Gaeumannomyces graminis 34.25 1.70e-02 33.10
IUUC-Gga-040668 Gallus gallus 87.15 0.00e+00 1686.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.32 0.00e+00 1194.00
IUUC-Gma-044336 Glycine max 33.33 2.00e-02 32.30
IUUC-Ggo-044462 Gorilla gorilla 99.16 0.00e+00 1963.00
IUUC-Hsa-045846 Homo sapiens 99.16 0.00e+00 1963.00
IUUC-Hvu-047163 Hordeum vulgare 39.06 9.80e-02 30.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 93.55 0.00e+00 833.00
IUUC-Kpa-049126 Komagataella pastoris 30.99 8.00e-04 37.00
IUUC-Lch-050303 Latimeria chalumnae 70.95 0.00e+00 1317.00
IUUC-Loc-052190 Lepisosteus oculatus 69.61 0.00e+00 1274.00
IUUC-Lma-052977 Leptosphaeria maculans 40.35 2.00e-04 39.30
IUUC-Laf-054480 Loxodonta africana 92.48 0.00e+00 760.00
IUUC-Mcc-055849 Macaca mulatta 98.85 0.00e+00 1957.00
IUUC-Meu-056755 Macropus eugenii 82.58 0.00e+00 875.00
IUUC-Mtr-058357 Medicago truncatula 37.93 3.30e-02 32.00
IUUC-Mla-059125 Melampsora laricipopulina 41.51 1.00e-03 37.00
IUUC-Mga-059561 Meleagris gallopavo 86.67 0.00e+00 1676.00
IUUC-Mmr-060942 Microcebus murinus 96.97 0.00e+00 1903.00
IUUC-Mdo-062618 Monodelphis domestica 92.36 0.00e+00 1844.00
IUUC-Mmu-063843 Mus musculus 94.25 0.00e+00 1815.00
IUUC-Mac-065590 Musa acuminata 28.00 2.00e-03 35.80
IUUC-Mpu-066919 Mustela putorius furo 96.55 0.00e+00 1907.00
IUUC-Mlu-066983 Myotis lucifugus 90.06 0.00e+00 1761.00
IUUC-Nfi-068351 Neosartorya fischeri 45.00 1.00e-03 36.60
IUUC-Ncr-068854 Neurospora crassa 30.30 2.00e-04 39.30
IUUC-Nle-069893 Nomascus leucogenys 99.27 0.00e+00 1964.00
IUUC-Opr-071181 Ochotona princeps 87.04 0.00e+00 1583.00
IUUC-Ont-071697 Oreochromis niloticus 66.50 0.00e+00 1187.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.06 0.00e+00 1774.00
IUUC-Ocu-074954 Oryctolagus cuniculus 96.65 0.00e+00 1913.00
IUUC-Oba-075033 Oryza barthii 34.92 1.60e-01 29.30
IUUC-Obr-076908 Oryza brachyantha 33.33 2.10e-01 29.30
IUUC-Ogl-077907 Oryza glaberrima 34.92 1.60e-01 29.60
IUUC-Ogu-078871 Oryza glumaepatula 34.92 1.60e-01 29.30
IUUC-Oin-080206 Oryza indica 34.92 1.60e-01 29.60
IUUC-Ome-081319 Oryza meridionalis 41.38 1.20e-01 28.10
IUUC-Opu-083656 Oryza punctata 34.92 1.50e-01 29.60
IUUC-Osa-085952 Oryza sativa 34.92 1.60e-01 29.60
IUUC-Ola-086523 Oryzias latipes 66.22 0.00e+00 1182.00
IUUC-Olu-087778 Ostreococcus lucimarinus 27.95 5.00e-03 34.70
IUUC-Oga-089003 Otolemur garnettii 97.07 0.00e+00 1919.00
IUUC-Oar-090376 Ovis aries 96.35 0.00e+00 1904.00
IUUC-Ptr-090520 Pan troglodytes 97.38 0.00e+00 1914.00
IUUC-Pan-092281 Papio anubis 98.95 0.00e+00 1951.00
IUUC-Psi-093047 Pelodiscus sinensis 88.63 0.00e+00 1614.00
IUUC-Pma-094575 Petromyzon marinus 55.50 1.00e-66 246.00
IUUC-Pno-094999 Phaeosphaeria nodorum 32.20 2.00e-03 36.20
IUUC-Pfo-096358 Poecilia formosa 66.22 0.00e+00 1134.00
IUUC-Pca-100461 Procavia capensis 86.03 0.00e+00 1528.00
IUUC-Ppe-101764 Prunus persica 33.33 3.60e-02 31.60
IUUC-Pva-102134 Pteropus vampyrus 85.36 0.00e+00 1665.00
IUUC-Pgr-103371 Puccinia graminis 39.71 1.00e-05 43.10
IUUC-Ptt-103764 Puccinia triticina 48.48 3.00e-03 35.80
IUUC-Pte-104265 Pyrenophora teres 31.94 2.00e-03 35.40
IUUC-Pyt-104528 Pyrenophora triticirepentis 31.94 2.00e-03 36.60
IUUC-Rno-105807 Rattus norvegicus 92.68 0.00e+00 1776.00
IUUC-Sha-107236 Sarcophilus harrisii 93.08 0.00e+00 1786.00
IUUC-Sja-107978 Schizosaccharomyces japonicus 46.43 2.00e-07 49.30
IUUC-Spo-108310 Schizosaccharomyces pombe 41.51 6.00e-05 40.80
IUUC-Sly-111811 Solanum lycopersicum 30.61 4.00e-03 34.70
IUUC-Stu-111984 Solanum tuberosum 29.59 1.60e-02 32.70
IUUC-Sar-113366 Sorex araneus 98.44 0.00e+00 938.00
IUUC-Sre-115083 Sporisorium reilianum 32.56 2.00e-03 36.20
IUUC-Ssc-116306 Sus scrofa 32.88 8.00e-04 37.40
IUUC-Tgu-117201 Taeniopygia guttata 84.05 0.00e+00 1611.00
IUUC-Tru-117953 Takifugu rubripes 67.74 0.00e+00 1185.00
IUUC-Tsy-119610 Tarsius syrichta 94.67 0.00e+00 1866.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.62 5.00e-165 574.00
IUUC-Tca-121819 Theobroma cacao 31.18 2.00e-03 36.20
IUUC-Tvi-122273 Trichoderma virens 37.21 1.50e+00 26.20
IUUC-Tur-126446 Triticum urartu 36.51 1.20e-01 29.30
IUUC-Tme-127153 Tuber melanosporum 36.07 2.00e-03 35.80
IUUC-Tbe-128155 Tupaia belangeri 79.38 0.00e+00 765.00
IUUC-Ttr-128942 Tursiops truncatus 91.21 0.00e+00 1785.00
IUUC-Uma-129608 Ustilago maydis 30.97 1.00e-05 43.50
IUUC-Vda-129806 Verticillium dahliae 34.25 8.00e-04 37.40
IUUC-Vpa-130281 Vicugna pacos 85.67 0.00e+00 1649.00
IUUC-Vvi-131178 Vitis vinifera 34.48 7.90e-02 30.40
IUUC-Xtr-132627 Xenopus tropicalis 75.91 0.00e+00 1396.00
IUUC-Xma-133449 Xiphophorus maculatus 64.93 0.00e+00 1097.00
IUUC-Yli-134439 Yarrowia lipolytica 40.00 7.00e-06 43.90
IUUC-Zma-135720 Zea mays 36.07 2.80e-01 28.90
Created Date 25-Jun-2017

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