iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004033

Ensembl Protein ID

ENSAPLP00000005630.1

UniProt Accession

U3IEF8; U3IEF8_ANAPL

Genbank Protein ID

ENSAPLP00000005630

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01082928

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000005991.1	ENSAPLT00000006261.1	ENSAPLP00000005630.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-82	277.7	344	960

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L++i++++++ll+   + ++++  k p ++l++ +++l+++    + + k+   +++++a++++ae+fsgy
   Q: 344  QGFSNLGNTCYMNAILQSLFSIQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLAKKDvcSPEVKKELLKKVKSAISATAERFSGY 427
           69*****************************...*****9..68*************9987678888899999**************** PP
   S: 88   eqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +k+++ e   ++d+s    + + + +k +++++  +++++++++i+c+ c+++ +++e+f+dls++
   Q: 428  MQNDAHEFLSQCLDQLKEDMEKlNKTWKSEPVPNDDNSPGRASDDLSATKVYTCPVISNLEFEVQHSIICKMCGETVTKREQFNDLSID 516
           ********************77455555555566666666777888999**************************************** PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++  ++ s+qd+L+ f+++ee+e    y+cekc++k+ a+ ++k+++lP+vLilhLkR+sf+ + + ++k+ ++v +p+ L+l +
   Q: 517  LPRRKKLLPSrSIQDSLDLFFRAEEIE----YSCEKCNGKS-AVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLS 600
           **9998876569**************9....********99.9********************************************** PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 601  HCTEstrlpltlgwsahsaisrplkasqmvnsctiststpcrkytfksksptalyvdsdsddeplkrsvahsqrlcniqtrdqqqlqee 689
           ***********************************************999999999999999999999999999999999999999888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 690  qekgskrskmegdkpelgnagfdgmsedellaavleiskreaslslnhdedkptsspdtgfgddeiqelpenletmemekpkaalesgp 778
           88888888888888888888888888888888888888888888888777777777777777777777777777777777777777777 PP
   S: 268  ......................................peekqke............................................ 274
                                                 +     e                                            
   Q: 779  anfteitkdfdenkenktpegsqgevdwlqqydmererE-----Eqelqqalaqslqeqeareqkedddlkratelslqefnsslldsv 862
           777777777766666666555555555555555555550.....055555666666666666666777777788888888888888888 PP
   S: 275  .................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
                                            +++Y+Li++v+H G ++ssGHY+++v++ k++ W++++D +V+ + e++v+ ++++
   Q: 863  gsdedsgnedvldmeyseaeaeelkrnaetgelPHSYRLISIVSHIGsTSSSGHYISDVYDIKKQsWFTYNDLEVSRTLETTVQCDRDR 951
           888888888888888888888899999999999****************************99889*********************** PP
   S: 329  taYvlfYkr 337
           ++Y++fY++
   Q: 952  SGYIFFYMH 960
           *******98 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MAPLKVHGPV RMRSMQTGIT KWKEGSFEIV EKDNKVSLVV HYNVGGIPKT FQLSHNIKTV 60
TLRPNGRKLC CLMLTLKDTS FLTIDKVPFK DANEMRMYLD AVHQDRVHTA GKASQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCCGC TGAAGGTGCA CGGGCCGGTG CGGATGCGCA GCATGCAGAC GGGCATCACC 60
AAGTGGAAGG AGGGCAGCTT CGAGATCGTG GAGAAGGACA ACAAAGTCAG CCTGGTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	77.50	0.00e+00	1394.00
IUUC-Aca-005370	Anolis carolinensis	74.92	0.00e+00	1382.00
IUUC-Ame-011884	Astyanax mexicanus	58.17	0.00e+00	973.00
IUUC-Bta-012725	Bos taurus	76.32	0.00e+00	1373.00
IUUC-Cja-019939	Callithrix jacchus	77.47	0.00e+00	1345.00
IUUC-Cfa-020835	Canis familiaris	77.68	0.00e+00	1427.00
IUUC-Cpo-022067	Cavia porcellus	75.98	0.00e+00	1246.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.37	1.00e-23	104.00
IUUC-Csa-023085	Chlorocebus sabaeus	77.83	0.00e+00	1391.00
IUUC-Cho-024390	Choloepus hoffmanni	65.92	3.00e-129	455.00
IUUC-Cin-025496	Ciona intestinalis	37.07	3.00e-40	159.00
IUUC-Csv-025812	Ciona savignyi	31.36	2.00e-37	150.00
IUUC-Dre-028255	Danio rerio	57.59	0.00e+00	922.00
IUUC-Dno-028986	Dasypus novemcinctus	77.19	0.00e+00	1369.00
IUUC-Dor-031062	Dipodomys ordii	67.24	0.00e+00	718.00
IUUC-Ete-032359	Echinops telfairi	68.07	0.00e+00	662.00
IUUC-Eca-033964	Equus caballus	77.23	0.00e+00	1392.00
IUUC-Eeu-034492	Erinaceus europaeus	73.12	0.00e+00	664.00
IUUC-Fca-036359	Felis catus	77.58	0.00e+00	1401.00
IUUC-Fal-037640	Ficedula albicollis	95.75	0.00e+00	1781.00
IUUC-Gmo-039600	Gadus morhua	56.35	0.00e+00	927.00
IUUC-Gga-040126	Gallus gallus	95.96	0.00e+00	1742.00
IUUC-Gac-041557	Gasterosteus aculeatus	55.16	0.00e+00	884.00
IUUC-Ggo-045571	Gorilla gorilla	73.11	0.00e+00	1204.00
IUUC-Hsa-046043	Homo sapiens	76.77	0.00e+00	1363.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	76.72	0.00e+00	1358.00
IUUC-Lch-050357	Latimeria chalumnae	67.80	0.00e+00	1072.00
IUUC-Loc-052849	Lepisosteus oculatus	62.64	0.00e+00	1026.00
IUUC-Laf-054570	Loxodonta africana	76.74	0.00e+00	1351.00
IUUC-Mcc-054989	Macaca mulatta	77.05	0.00e+00	1271.00
IUUC-Meu-056273	Macropus eugenii	59.32	1.00e-157	550.00
IUUC-Mga-059814	Meleagris gallopavo	93.33	0.00e+00	1726.00
IUUC-Mmr-061726	Microcebus murinus	77.02	0.00e+00	1374.00
IUUC-Mdo-062974	Monodelphis domestica	80.71	0.00e+00	1488.00
IUUC-Mmu-064069	Mus musculus	75.91	0.00e+00	1321.00
IUUC-Mpu-066008	Mustela putorius furo	76.87	0.00e+00	1363.00
IUUC-Mlu-068224	Myotis lucifugus	38.51	1.00e-148	520.00
IUUC-Nle-069259	Nomascus leucogenys	77.53	0.00e+00	1364.00
IUUC-Opr-070882	Ochotona princeps	66.77	1.00e-109	390.00
IUUC-Ont-072441	Oreochromis niloticus	56.22	0.00e+00	918.00
IUUC-Oan-073151	Ornithorhynchus anatinus	82.47	9.00e-115	405.00
IUUC-Ocu-074879	Oryctolagus cuniculus	76.32	0.00e+00	1348.00
IUUC-Ola-087007	Oryzias latipes	54.16	0.00e+00	844.00
IUUC-Oga-088385	Otolemur garnettii	76.31	0.00e+00	1366.00
IUUC-Oar-090305	Ovis aries	76.92	0.00e+00	1393.00
IUUC-Ptr-091299	Pan troglodytes	77.33	0.00e+00	1360.00
IUUC-Pan-091996	Papio anubis	77.65	0.00e+00	1342.00
IUUC-Psi-093176	Pelodiscus sinensis	90.62	0.00e+00	1695.00
IUUC-Pma-094331	Petromyzon marinus	46.95	0.00e+00	750.00
IUUC-Ppa-095732	Physcomitrella patens	27.95	3.00e-21	96.70
IUUC-Pfo-096503	Poecilia formosa	55.28	0.00e+00	876.00
IUUC-Pab-098543	Pongo abelii	78.93	0.00e+00	741.00
IUUC-Pca-101099	Procavia capensis	72.66	0.00e+00	1058.00
IUUC-Pva-103163	Pteropus vampyrus	74.41	0.00e+00	928.00
IUUC-Rno-105766	Rattus norvegicus	76.21	0.00e+00	1325.00
IUUC-Sha-106610	Sarcophilus harrisii	76.31	0.00e+00	1373.00
IUUC-Sar-113624	Sorex araneus	37.23	7.00e-79	288.00
IUUC-Ssc-116353	Sus scrofa	76.46	0.00e+00	1351.00
IUUC-Tgu-116971	Taeniopygia guttata	95.15	0.00e+00	1746.00
IUUC-Tru-117932	Takifugu rubripes	47.40	2.00e-133	469.00
IUUC-Tsy-119185	Tarsius syrichta	72.57	0.00e+00	881.00
IUUC-Tni-119842	Tetraodon nigroviridis	62.03	6.00e-109	387.00
IUUC-Tbe-127281	Tupaia belangeri	65.12	4.00e-151	528.00
IUUC-Ttr-128177	Tursiops truncatus	80.47	0.00e+00	1090.00
IUUC-Vpa-130031	Vicugna pacos	77.53	0.00e+00	1407.00
IUUC-Xtr-132949	Xenopus tropicalis	68.54	0.00e+00	1205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence