iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-21	76.5	608	646

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 608  GHTDGASCIDIsHDgTKLWTGGLDNTVRSWDLREGRQLQ 646
           8**********9888*********************998 PP

Organism

Rattus norvegicus

Functional Description
(View)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Protein Sequence
(Fasta)

MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGAGGCTT CCTATGCCGG CTGGAGTTAG GATGCCACGG CCCATTATTT GCACCGACTA 60
ACCCGGAGTT CCTCCTCGGC CCTGGGAAGG ACTGGCGGCG GCGGCTGGAG CAGACAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway

KEGG

rno:84424

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002200	Ailuropoda melanoleuca	99.48	0.00e+00	1387.00
IUUC-Aca-005074	Anolis carolinensis	92.44	0.00e+00	1041.00
IUUC-Ame-010724	Astyanax mexicanus	88.47	0.00e+00	1259.00
IUUC-Bta-013189	Bos taurus	98.70	0.00e+00	1382.00
IUUC-Cel-018361	Caenorhabditis elegans	58.43	3.00e-119	422.00
IUUC-Cja-018781	Callithrix jacchus	98.06	0.00e+00	1369.00
IUUC-Cfa-021016	Canis familiaris	97.23	0.00e+00	1274.00
IUUC-Cpo-021793	Cavia porcellus	97.26	0.00e+00	1359.00
IUUC-Csa-023928	Chlorocebus sabaeus	98.44	0.00e+00	1375.00
IUUC-Csv-026174	Ciona savignyi	58.23	3.00e-160	558.00
IUUC-Dre-028595	Danio rerio	90.19	0.00e+00	1254.00
IUUC-Dno-029736	Dasypus novemcinctus	93.68	0.00e+00	1248.00
IUUC-Dor-030787	Dipodomys ordii	91.94	0.00e+00	1040.00
IUUC-Dme-031576	Drosophila melanogaster	84.92	0.00e+00	660.00
IUUC-Ete-032685	Echinops telfairi	95.12	0.00e+00	1282.00
IUUC-Eca-033249	Equus caballus	98.31	0.00e+00	1367.00
IUUC-Fca-036239	Felis catus	97.60	0.00e+00	1246.00
IUUC-Gmo-039000	Gadus morhua	84.40	0.00e+00	1136.00
IUUC-Gac-041924	Gasterosteus aculeatus	89.73	0.00e+00	1236.00
IUUC-Ggo-044458	Gorilla gorilla	98.29	0.00e+00	1398.00
IUUC-Hsa-046549	Homo sapiens	98.19	0.00e+00	1372.00
IUUC-Lch-050110	Latimeria chalumnae	92.82	0.00e+00	1247.00
IUUC-Loc-052165	Lepisosteus oculatus	92.83	0.00e+00	1286.00
IUUC-Laf-053817	Loxodonta africana	96.37	0.00e+00	1372.00
IUUC-Mcc-055673	Macaca mulatta	95.78	0.00e+00	1368.00
IUUC-Meu-056601	Macropus eugenii	95.06	0.00e+00	1353.00
IUUC-Mga-059792	Meleagris gallopavo	84.97	0.00e+00	1030.00
IUUC-Mmr-060904	Microcebus murinus	96.16	0.00e+00	1368.00
IUUC-Mdo-061897	Monodelphis domestica	93.78	0.00e+00	1341.00
IUUC-Mmu-063702	Mus musculus	96.81	0.00e+00	1347.00
IUUC-Mpu-066618	Mustela putorius furo	98.70	0.00e+00	1379.00
IUUC-Mlu-067934	Myotis lucifugus	98.95	0.00e+00	1380.00
IUUC-Nle-069452	Nomascus leucogenys	98.44	0.00e+00	1376.00
IUUC-Opr-070854	Ochotona princeps	91.78	0.00e+00	1174.00
IUUC-Ont-071865	Oreochromis niloticus	90.10	0.00e+00	1269.00
IUUC-Ocu-074091	Oryctolagus cuniculus	98.17	0.00e+00	1338.00
IUUC-Ola-086424	Oryzias latipes	90.25	0.00e+00	1252.00
IUUC-Oga-088548	Otolemur garnettii	97.54	0.00e+00	1389.00
IUUC-Oar-089856	Ovis aries	97.77	0.00e+00	1371.00
IUUC-Ptr-090848	Pan troglodytes	98.44	0.00e+00	1375.00
IUUC-Pan-092288	Papio anubis	99.08	0.00e+00	1382.00
IUUC-Psi-093427	Pelodiscus sinensis	95.58	0.00e+00	1326.00
IUUC-Pma-094452	Petromyzon marinus	77.37	0.00e+00	1094.00
IUUC-Pfo-096613	Poecilia formosa	90.01	0.00e+00	1268.00
IUUC-Pab-098175	Pongo abelii	98.57	0.00e+00	1377.00
IUUC-Pca-100321	Procavia capensis	96.89	0.00e+00	1366.00
IUUC-Pva-102741	Pteropus vampyrus	91.72	0.00e+00	1258.00
IUUC-Sha-106568	Sarcophilus harrisii	95.48	0.00e+00	1346.00
IUUC-Sar-113414	Sorex araneus	93.56	0.00e+00	632.00
IUUC-Ssc-116160	Sus scrofa	98.03	0.00e+00	1374.00
IUUC-Tru-117982	Takifugu rubripes	84.73	0.00e+00	1257.00
IUUC-Tni-120823	Tetraodon nigroviridis	90.87	0.00e+00	1275.00
IUUC-Ttr-128845	Tursiops truncatus	97.93	0.00e+00	1390.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence