iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036485

Ensembl Protein ID

ENSFCAP00000010418.3

UniProt Accession

M3WEP0; M3WEP0_FELCA

Genbank Protein ID

ENSFCAP00000010418

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02147825

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000011214.3	ENSFCAT00000011219.3	ENSFCAP00000010418.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-78	262.4	2458	2781

Active Site

Position(s)	Description	Evidence
2751	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 15   gEegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyk 98
            Ee+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k
   Q: 2458 PEENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIK 2540
           5999999****************999878888334444777777777775....89******************************* PP
   S: 99   lllgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrl 182
            llg+k++++d+  + p +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+
   Q: 2541 VLLGRKVNWHDFVFF-PVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM 2626
           ************987.8888884566666664456888999********************************************** PP
   S: 183  kegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafL 265
               ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++
   Q: 2627 LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLV 2713
           *****************************************************9999999999989999****************** PP
   S: 266  qFvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2714 YFWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2781
           ***********999******..799999.99**********************************9.99875 PP

Organism

Felis catus

Protein Sequence
(Fasta)

RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE 60
LGKPDNNDGS KLNSNSGAGR TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTTACGGG AAGTTTCAGA GAAACTGAAC AAATACAACT TAAACAGGTA ATAGTTTTAA 60
GGTATTTTAA ATTTTCTGAA AACGATTTTT CTTAACTAGG AAAAAGAACT CATTTAGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	98.20	0.00e+00	4492.00
IUUC-Apl-004165	Anas platyrhynchos	96.02	0.00e+00	4418.00
IUUC-Aca-004577	Anolis carolinensis	95.50	0.00e+00	3841.00
IUUC-Ame-010702	Astyanax mexicanus	84.42	0.00e+00	2454.00
IUUC-Bta-012313	Bos taurus	98.17	0.00e+00	4515.00
IUUC-Cel-018165	Caenorhabditis elegans	43.29	9.00e-65	243.00
IUUC-Cja-019858	Callithrix jacchus	97.92	0.00e+00	4531.00
IUUC-Cfa-020973	Canis familiaris	98.24	0.00e+00	4522.00
IUUC-Cpo-022108	Cavia porcellus	94.49	0.00e+00	1853.00
IUUC-Csa-023985	Chlorocebus sabaeus	97.88	0.00e+00	4542.00
IUUC-Cho-025034	Choloepus hoffmanni	89.06	0.00e+00	978.00
IUUC-Cin-025715	Ciona intestinalis	39.18	0.00e+00	864.00
IUUC-Csv-026088	Ciona savignyi	38.43	5.00e-142	498.00
IUUC-Dre-027730	Danio rerio	86.58	0.00e+00	3917.00
IUUC-Dno-029123	Dasypus novemcinctus	95.55	0.00e+00	4345.00
IUUC-Dor-030757	Dipodomys ordii	92.67	0.00e+00	2813.00
IUUC-Dme-032192	Drosophila melanogaster	51.03	5.00e-169	590.00
IUUC-Ete-032292	Echinops telfairi	93.66	0.00e+00	2108.00
IUUC-Eca-034347	Equus caballus	97.95	0.00e+00	4456.00
IUUC-Eeu-034873	Erinaceus europaeus	93.32	0.00e+00	4272.00
IUUC-Fal-037071	Ficedula albicollis	96.62	0.00e+00	4418.00
IUUC-Gmo-039589	Gadus morhua	86.98	0.00e+00	3898.00
IUUC-Gga-041195	Gallus gallus	95.26	0.00e+00	4313.00
IUUC-Gac-042538	Gasterosteus aculeatus	87.28	0.00e+00	3920.00
IUUC-Ggo-045351	Gorilla gorilla	97.17	0.00e+00	4570.00
IUUC-Hsa-045941	Homo sapiens	97.88	0.00e+00	4554.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	97.77	0.00e+00	4501.00
IUUC-Lch-050480	Latimeria chalumnae	92.94	0.00e+00	4259.00
IUUC-Loc-052664	Lepisosteus oculatus	88.18	0.00e+00	4014.00
IUUC-Laf-053935	Loxodonta africana	95.42	0.00e+00	1526.00
IUUC-Mcc-054703	Macaca mulatta	97.84	0.00e+00	4539.00
IUUC-Meu-056431	Macropus eugenii	87.62	0.00e+00	802.00
IUUC-Mga-059289	Meleagris gallopavo	95.90	0.00e+00	3529.00
IUUC-Mmr-061737	Microcebus murinus	97.59	0.00e+00	4439.00
IUUC-Mdo-062499	Monodelphis domestica	96.77	0.00e+00	4434.00
IUUC-Mmu-063273	Mus musculus	96.80	0.00e+00	4404.00
IUUC-Mpu-066907	Mustela putorius furo	97.89	0.00e+00	4137.00
IUUC-Mlu-067942	Myotis lucifugus	97.92	0.00e+00	4513.00
IUUC-Nle-069527	Nomascus leucogenys	97.95	0.00e+00	4559.00
IUUC-Opr-070626	Ochotona princeps	83.25	0.00e+00	1365.00
IUUC-Ont-071951	Oreochromis niloticus	85.94	0.00e+00	3860.00
IUUC-Oan-072958	Ornithorhynchus anatinus	96.87	0.00e+00	4096.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.30	0.00e+00	4393.00
IUUC-Ola-086757	Oryzias latipes	87.36	0.00e+00	3950.00
IUUC-Oga-088781	Otolemur garnettii	97.84	0.00e+00	4502.00
IUUC-Oar-089274	Ovis aries	97.92	0.00e+00	4474.00
IUUC-Ptr-090669	Pan troglodytes	97.36	0.00e+00	3945.00
IUUC-Pan-092226	Papio anubis	98.02	0.00e+00	4541.00
IUUC-Psi-093502	Pelodiscus sinensis	96.91	0.00e+00	4437.00
IUUC-Pma-094454	Petromyzon marinus	76.70	0.00e+00	666.00
IUUC-Pfo-096173	Poecilia formosa	86.88	0.00e+00	3665.00
IUUC-Pab-098355	Pongo abelii	95.58	0.00e+00	3222.00
IUUC-Pca-100570	Procavia capensis	93.76	0.00e+00	1093.00
IUUC-Pva-102572	Pteropus vampyrus	91.35	0.00e+00	1275.00
IUUC-Rno-104916	Rattus norvegicus	94.87	0.00e+00	3886.00
IUUC-Sha-106653	Sarcophilus harrisii	96.98	0.00e+00	4447.00
IUUC-Sar-113517	Sorex araneus	91.42	0.00e+00	1291.00
IUUC-Ssc-115470	Sus scrofa	99.22	0.00e+00	2451.00
IUUC-Tgu-116932	Taeniopygia guttata	96.37	0.00e+00	4404.00
IUUC-Tru-117682	Takifugu rubripes	85.98	0.00e+00	2498.00
IUUC-Tsy-119417	Tarsius syrichta	92.46	0.00e+00	2380.00
IUUC-Tni-120442	Tetraodon nigroviridis	83.33	0.00e+00	3571.00
IUUC-Tbe-127456	Tupaia belangeri	86.46	0.00e+00	1362.00
IUUC-Ttr-128606	Tursiops truncatus	96.31	0.00e+00	1585.00
IUUC-Vpa-130112	Vicugna pacos	95.18	0.00e+00	3658.00
IUUC-Xtr-131929	Xenopus tropicalis	93.01	0.00e+00	4314.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence