iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004705

Ensembl Protein ID

ENSACAP00000014142.2

UniProt Accession

G1KPV2; G1KPV2_ANOCA

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014195.2	ENSACAT00000014432.2	ENSACAP00000014142.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.10e-23	80.7	907	956

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsekwiCpkC 51
           ++C vCg+ g++ +  l+ C++C +++Hp C+++++ + +  +  w C +C
   Q: 907  DMCVVCGSFGKGAEgRLLSCSQCGQCYHPYCVSIKITKVVLHK-GWRCLEC 956
           79*********9999********************66555555.5****** PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

RPRSRGKSAV EDEDSMDGLE AAETENTVET EIKEQSPEEE AQAEEDGDKK LTQTLQSSVS 60
GEPASPVASV GVEAKTSDRL CAFCYCGERS SLGQGELKQY CPTPGFLAPW SSQPLNKSET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCTCGAA GTAGAGGAAA ATCTGCAGTG GAGGATGAAG ACAGCATGGA TGGGTTGGAA 60
GCAGCAGAAA CAGAAAACAC TGTGGAAACC GGTAAAGCAT ACATTCCTAG TGGTGATGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	66.50	0.00e+00	5187.00
IUUC-Apl-003311	Anas platyrhynchos	71.66	0.00e+00	5717.00
IUUC-Aly-006363	Arabidopsis lyrata	33.51	9.00e-26	112.00
IUUC-Ath-007307	Arabidopsis thaliana	32.46	1.00e-25	112.00
IUUC-Bta-012322	Bos taurus	65.19	0.00e+00	4906.00
IUUC-Bol-015791	Brassica oleracea	34.55	4.00e-27	116.00
IUUC-Bra-017422	Brassica rapa	34.55	2.00e-27	117.00
IUUC-Cja-019983	Callithrix jacchus	66.50	0.00e+00	5381.00
IUUC-Cfa-020903	Canis familiaris	65.40	0.00e+00	5231.00
IUUC-Cpo-021732	Cavia porcellus	62.45	0.00e+00	3568.00
IUUC-Csa-023083	Chlorocebus sabaeus	63.32	0.00e+00	3788.00
IUUC-Cho-024469	Choloepus hoffmanni	58.04	0.00e+00	1488.00
IUUC-Cme-027224	Cyanidioschyzon merolae	36.71	1.00e-11	65.90
IUUC-Dre-028110	Danio rerio	59.30	0.00e+00	1098.00
IUUC-Dor-030569	Dipodomys ordii	62.63	0.00e+00	3208.00
IUUC-Dme-031590	Drosophila melanogaster	33.62	7.00e-69	256.00
IUUC-Eca-033945	Equus caballus	65.06	0.00e+00	3650.00
IUUC-Fca-035922	Felis catus	65.50	0.00e+00	5081.00
IUUC-Gmo-039403	Gadus morhua	53.97	0.00e+00	1156.00
IUUC-Gac-041896	Gasterosteus aculeatus	49.61	0.00e+00	1325.00
IUUC-Gma-043720	Glycine max	31.34	7.00e-27	115.00
IUUC-Ggo-044812	Gorilla gorilla	65.08	0.00e+00	5177.00
IUUC-Hsa-046595	Homo sapiens	66.80	0.00e+00	5370.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	65.61	0.00e+00	5173.00
IUUC-Lch-050086	Latimeria chalumnae	55.77	0.00e+00	2555.00
IUUC-Loc-052891	Lepisosteus oculatus	51.35	0.00e+00	2131.00
IUUC-Laf-054348	Loxodonta africana	64.01	0.00e+00	2256.00
IUUC-Mcc-054868	Macaca mulatta	66.70	0.00e+00	5301.00
IUUC-Meu-056322	Macropus eugenii	59.85	0.00e+00	1006.00
IUUC-Mga-059541	Meleagris gallopavo	71.15	0.00e+00	5596.00
IUUC-Mmr-061092	Microcebus murinus	63.04	0.00e+00	3807.00
IUUC-Mdo-062610	Monodelphis domestica	68.92	0.00e+00	1865.00
IUUC-Mmu-063666	Mus musculus	65.03	0.00e+00	5082.00
IUUC-Mpu-066366	Mustela putorius furo	65.98	0.00e+00	4842.00
IUUC-Mlu-068201	Myotis lucifugus	62.07	0.00e+00	2956.00
IUUC-Nle-069232	Nomascus leucogenys	63.07	0.00e+00	3754.00
IUUC-Opr-070625	Ochotona princeps	58.30	0.00e+00	936.00
IUUC-Ont-072401	Oreochromis niloticus	45.88	0.00e+00	951.00
IUUC-Oan-072945	Ornithorhynchus anatinus	65.78	0.00e+00	3737.00
IUUC-Ocu-074920	Oryctolagus cuniculus	62.04	0.00e+00	3745.00
IUUC-Ola-086436	Oryzias latipes	45.61	0.00e+00	1338.00
IUUC-Oga-088637	Otolemur garnettii	62.04	0.00e+00	2981.00
IUUC-Oar-089363	Ovis aries	66.31	0.00e+00	4183.00
IUUC-Ptr-091527	Pan troglodytes	66.71	0.00e+00	5405.00
IUUC-Pan-092102	Papio anubis	64.42	0.00e+00	5091.00
IUUC-Pma-094252	Petromyzon marinus	45.15	1.00e-117	419.00
IUUC-Pfo-096288	Poecilia formosa	59.40	0.00e+00	1019.00
IUUC-Pab-098241	Pongo abelii	65.05	0.00e+00	3311.00
IUUC-Pop-099585	Populus trichocarpa	30.89	1.00e-24	108.00
IUUC-Pca-100103	Procavia capensis	81.68	0.00e+00	1196.00
IUUC-Pva-102238	Pteropus vampyrus	61.53	0.00e+00	1861.00
IUUC-Sha-106550	Sarcophilus harrisii	64.07	0.00e+00	3865.00
IUUC-Sar-113183	Sorex araneus	83.54	6.00e-143	503.00
IUUC-Tgu-116677	Taeniopygia guttata	70.83	0.00e+00	5308.00
IUUC-Tru-118037	Takifugu rubripes	49.94	0.00e+00	1177.00
IUUC-Tsy-118932	Tarsius syrichta	65.87	0.00e+00	3759.00
IUUC-Tni-119970	Tetraodon nigroviridis	51.10	0.00e+00	1135.00
IUUC-Ttr-129051	Tursiops truncatus	65.69	0.00e+00	4746.00
IUUC-Vpa-130236	Vicugna pacos	59.20	0.00e+00	1211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence