iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118412

Ensembl Protein ID

ENSTRUP00000014381.1

UniProt Accession

H2SPP4; H2SPP4_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000005906.1	ENSTRUT00000014447.1	ENSTRUP00000014381.1
ENSTRUG00000005906.1	ENSTRUT00000014448.1	ENSTRUP00000014382.1
ENSTRUG00000005906.1	ENSTRUT00000014449.1	ENSTRUP00000014383.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.60e-39	131.2	1815	1850
UBD/Beta-Prp	8.70e-74	249.6	1383	1616

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           H+d++t++ + + + ++s+s+Dg + +WDl +g +lk
   Q: 1815 HKDWITSCVWsP-HCVISSSNDGRLCLWDLQSGQCLK 1850
           **********65.779*******************97 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
             tc+  s d++++++g   g++   d+++g  ++sl +  ++++++ f +dg  l+t+s  + +  wd+ +g+ +  +++h++ ++
   Q: 1383 KPTCMVLSSDGQMMVVGTGHGMLHFIDTQSGLEVKSLVSSCDGISSCVFLKDG-HLATTSFNGKLEMWDIGSGCRTAFIEAHTNAIT 1468
           567888899****************************99999**********9.8******************************** PP
   S: 99   slsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           + ++  + +++++ s d++++vw   + +++ + ls   g  ncv++hp++ ll++G+ ++ v +W+  ++k    + g h++sv+s
   Q: 1469 ASDVTVDMKHVATVSLDSMLKVWSSTKAYEVAAWLS--PGPLNCVSFHPEEHLLAAGCWNGNVIMWNWLQNKSDVSFCG-HKSSVRS 1552
           ***********************9999999986665..566*************************************9.******* PP
   S: 186  lsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           lsf+s+   + sgs  g +++w++ + +cv  +++h+  + ++ f++++  l+s+ssD ++++W 
   Q: 1553 LSFSSS-STMCSGSVSGEIRVWSVPNFTCVGCFQAHSGATEVLTFLDEGRMLLSASSDHTLKLWS 1616
           *****6.5899*****************************************************5 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

DPQFLLKVAV YTRQQLNIRI TANFLLALAA SQPSTKPHVR RYFSAAVQLP SDWLEVVRIY 60
STCFSSSLPM CLKKALVDKF KEFSEYQLAK YNTRKHRCKH NHNKGKSKEQ TVKIFSETES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTGAAA TGGAGCTTAA AGATAAAAAA GTAATAAATC TTTTAATTGT ATATTTTTTA 60
AATTATGTTT TTGTTATCTA GTAATTTTTT TATGTTTTAT GTTTTTCTGA TAGTTTATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR025139--DUF4062
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase
IPR023302--Pept_S9A_N
IPR011047--Quinoprotein_ADH-like_supfam
IPR008858--TROVE_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50837--NACHT
PS50988--TROVE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13271--DUF4062
PF05731--TROVE
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0003723--F:RNA binding
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001482	Ailuropoda melanoleuca	32.35	0.00e+00	1083.00
IUUC-Aca-005102	Anolis carolinensis	34.57	0.00e+00	1163.00
IUUC-Ame-011822	Astyanax mexicanus	49.06	0.00e+00	1186.00
IUUC-Bta-012323	Bos taurus	32.86	0.00e+00	1070.00
IUUC-Cja-019005	Callithrix jacchus	32.78	0.00e+00	1138.00
IUUC-Cfa-020803	Canis familiaris	31.76	0.00e+00	976.00
IUUC-Cpo-022312	Cavia porcellus	32.33	0.00e+00	1082.00
IUUC-Csa-023287	Chlorocebus sabaeus	32.73	0.00e+00	1112.00
IUUC-Dre-028825	Danio rerio	50.63	0.00e+00	1982.00
IUUC-Dno-029455	Dasypus novemcinctus	31.54	0.00e+00	993.00
IUUC-Dor-030328	Dipodomys ordii	30.28	0.00e+00	727.00
IUUC-Ete-032385	Echinops telfairi	36.89	0.00e+00	734.00
IUUC-Eca-033726	Equus caballus	32.61	0.00e+00	1105.00
IUUC-Eeu-034665	Erinaceus europaeus	36.59	1.00e-88	323.00
IUUC-Fca-035365	Felis catus	33.32	0.00e+00	1050.00
IUUC-Gmo-039584	Gadus morhua	52.08	0.00e+00	970.00
IUUC-Gac-042307	Gasterosteus aculeatus	62.37	0.00e+00	2243.00
IUUC-Ggo-045432	Gorilla gorilla	31.44	0.00e+00	1031.00
IUUC-Hsa-046182	Homo sapiens	32.43	0.00e+00	1102.00
IUUC-Itr-049021	Ictidomys tridecemlineatus	32.62	0.00e+00	1117.00
IUUC-Lch-050186	Latimeria chalumnae	34.72	4.00e-71	261.00
IUUC-Laf-054524	Loxodonta africana	33.77	0.00e+00	1096.00
IUUC-Mcc-055628	Macaca mulatta	32.71	0.00e+00	1113.00
IUUC-Meu-056338	Macropus eugenii	35.60	0.00e+00	644.00
IUUC-Mmr-060854	Microcebus murinus	33.04	0.00e+00	1127.00
IUUC-Mdo-062247	Monodelphis domestica	32.15	0.00e+00	1043.00
IUUC-Mmu-064406	Mus musculus	32.78	0.00e+00	1124.00
IUUC-Mpu-065806	Mustela putorius furo	32.63	0.00e+00	1133.00
IUUC-Mlu-068116	Myotis lucifugus	32.64	0.00e+00	1043.00
IUUC-Nle-069628	Nomascus leucogenys	33.43	0.00e+00	1036.00
IUUC-Opr-070242	Ochotona princeps	29.49	0.00e+00	730.00
IUUC-Oan-073598	Ornithorhynchus anatinus	34.30	1.00e-162	568.00
IUUC-Ocu-073933	Oryctolagus cuniculus	33.28	0.00e+00	1122.00
IUUC-Ola-086886	Oryzias latipes	60.40	0.00e+00	2255.00
IUUC-Oga-088609	Otolemur garnettii	31.97	0.00e+00	1088.00
IUUC-Oar-089957	Ovis aries	32.17	0.00e+00	1026.00
IUUC-Ptr-090577	Pan troglodytes	32.32	0.00e+00	1094.00
IUUC-Pan-092397	Papio anubis	32.68	0.00e+00	1101.00
IUUC-Pma-094373	Petromyzon marinus	27.74	5.00e-47	182.00
IUUC-Pfo-096497	Poecilia formosa	61.05	0.00e+00	2179.00
IUUC-Pab-098028	Pongo abelii	32.81	0.00e+00	1103.00
IUUC-Pca-101002	Procavia capensis	33.50	3.00e-174	607.00
IUUC-Pva-102144	Pteropus vampyrus	37.10	9.00e-169	588.00
IUUC-Rno-105828	Rattus norvegicus	32.93	0.00e+00	1109.00
IUUC-Sha-106469	Sarcophilus harrisii	32.10	0.00e+00	1062.00
IUUC-Sar-113035	Sorex araneus	29.99	2.00e-117	418.00
IUUC-Ssc-116122	Sus scrofa	31.01	0.00e+00	750.00
IUUC-Tsy-119257	Tarsius syrichta	33.43	4.00e-104	374.00
IUUC-Tni-120032	Tetraodon nigroviridis	81.67	2.00e-129	455.00
IUUC-Tbe-127312	Tupaia belangeri	42.82	6.00e-78	287.00
IUUC-Ttr-128335	Tursiops truncatus	31.64	0.00e+00	1004.00
IUUC-Xtr-132524	Xenopus tropicalis	34.27	0.00e+00	1026.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence