iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001822

Ensembl Protein ID

ENSAMEP00000007109.1

UniProt Accession

G1LJK4; G1LJK4_AILME

Genbank Protein ID

ENSAMEP00000007109

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01010735

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000006741.1	ENSAMET00000007411.1	ENSAMEP00000007109.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.80e-14	54.1	148	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLk 60
           +e+rl+++t ++r+r+lLd+++v++++l++fll +++el+++ a + ++++++ + ++
   Q: 148  DEIRLPIFTSSQRARRLLDLATVKANGLAAFLLRHVQELPVPLALPFEDAACK-KYMS 204
           8***************************************************9.5555 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

LSSPGYEMCT QDAFQAQRSQ LVGLLVSGSL EGFESVLDWL LSWEVLSWED YEGLSLPGQP 60
LSRLARRLLD TVWNKGAWGC EQLVAAVREA QTDCQAPELS SCWDPHSPQP ARDLQSHRPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCCTCCC CAGGTTATGA AATGTGCACA CAGGATGCTT TCCAGGCTCA GAGGAGCCAG 60
CTGGTGGGGC TGCTGGTCTC AGGGTCCCTG GAGGGCTTCG AGAGCGTCCT GGACTGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011021	Astyanax mexicanus	46.36	0.00e+00	879.00
IUUC-Bta-013241	Bos taurus	81.34	0.00e+00	1590.00
IUUC-Cja-019633	Callithrix jacchus	77.62	0.00e+00	1159.00
IUUC-Cfa-020039	Canis familiaris	88.06	0.00e+00	1708.00
IUUC-Cpo-022337	Cavia porcellus	76.50	0.00e+00	1447.00
IUUC-Csa-023906	Chlorocebus sabaeus	81.20	0.00e+00	1587.00
IUUC-Dre-027568	Danio rerio	46.09	0.00e+00	813.00
IUUC-Dno-029098	Dasypus novemcinctus	79.74	0.00e+00	1444.00
IUUC-Dor-031102	Dipodomys ordii	72.30	0.00e+00	679.00
IUUC-Ete-032943	Echinops telfairi	73.67	0.00e+00	1061.00
IUUC-Eca-034310	Equus caballus	84.71	0.00e+00	1599.00
IUUC-Eeu-034589	Erinaceus europaeus	79.00	3.00e-165	575.00
IUUC-Fca-036252	Felis catus	84.48	0.00e+00	850.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.03	0.00e+00	805.00
IUUC-Ggo-044861	Gorilla gorilla	82.12	0.00e+00	1560.00
IUUC-Hsa-046093	Homo sapiens	81.73	0.00e+00	1553.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	79.13	0.00e+00	1418.00
IUUC-Lch-049454	Latimeria chalumnae	53.77	0.00e+00	914.00
IUUC-Laf-053553	Loxodonta africana	81.27	0.00e+00	1451.00
IUUC-Mcc-055772	Macaca mulatta	81.24	0.00e+00	1565.00
IUUC-Meu-056785	Macropus eugenii	66.67	2.00e-110	394.00
IUUC-Mmr-060596	Microcebus murinus	80.67	0.00e+00	1499.00
IUUC-Mdo-062983	Monodelphis domestica	66.86	0.00e+00	1095.00
IUUC-Mmu-063951	Mus musculus	74.69	0.00e+00	1452.00
IUUC-Mpu-066412	Mustela putorius furo	89.24	0.00e+00	1720.00
IUUC-Mlu-067601	Myotis lucifugus	79.45	0.00e+00	1402.00
IUUC-Nle-069913	Nomascus leucogenys	81.69	0.00e+00	1300.00
IUUC-Opr-070999	Ochotona princeps	77.88	0.00e+00	893.00
IUUC-Ont-072512	Oreochromis niloticus	46.50	0.00e+00	873.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.11	0.00e+00	1097.00
IUUC-Ocu-074837	Oryctolagus cuniculus	81.43	0.00e+00	1546.00
IUUC-Ola-086555	Oryzias latipes	46.29	0.00e+00	812.00
IUUC-Oga-088909	Otolemur garnettii	80.39	0.00e+00	1514.00
IUUC-Oar-089315	Ovis aries	79.78	0.00e+00	1515.00
IUUC-Ptr-090542	Pan troglodytes	81.83	0.00e+00	1553.00
IUUC-Pan-092545	Papio anubis	81.50	0.00e+00	1563.00
IUUC-Pma-094167	Petromyzon marinus	34.82	1.00e-64	241.00
IUUC-Ppa-095344	Physcomitrella patens	22.83	2.00e-04	41.20
IUUC-Pfo-096976	Poecilia formosa	45.27	0.00e+00	833.00
IUUC-Pab-098481	Pongo abelii	81.63	0.00e+00	1547.00
IUUC-Pca-100135	Procavia capensis	74.62	0.00e+00	1254.00
IUUC-Pva-102127	Pteropus vampyrus	80.29	0.00e+00	1420.00
IUUC-Pgr-103409	Puccinia graminis	40.00	8.70e-01	27.70
IUUC-Pte-104066	Pyrenophora teres	35.09	3.10e-01	32.00
IUUC-Rno-105783	Rattus norvegicus	77.07	0.00e+00	1454.00
IUUC-Sce-106163	Saccharomyces cerevisiae	26.92	7.00e-03	37.00
IUUC-Sar-113448	Sorex araneus	75.11	0.00e+00	928.00
IUUC-Tru-118708	Takifugu rubripes	44.51	0.00e+00	773.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.42	3.00e-32	132.00
IUUC-Tme-127168	Tuber melanosporum	28.17	6.30e+00	25.00
IUUC-Tbe-127661	Tupaia belangeri	78.83	0.00e+00	765.00
IUUC-Ttr-128318	Tursiops truncatus	76.63	0.00e+00	1374.00
IUUC-Vpa-130502	Vicugna pacos	77.04	2.00e-164	573.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence