iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggr-039957

Ensembl Protein ID

GGTG_01196T0

UniProt Accession

J3NIW2; J3NIW2_GAGT3

Genbank Protein ID

EJT81212.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

ADBI01000122

Gene Name

PAN2; GGTG_01196

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GGTG_01196	GGTG_01196T0	GGTG_01196T0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-15	54.8	497	832

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaq.Efl 96
           Gl+N+ +  Y NS+LQ+++++p lr+l l++   ++       ++++ll++l  lf  l k k    + +++lk+l +     +    + D +   l
   Q: 497  GLENHIANSYANSLLQVMHFTPILRNLSLQHAATACL------SEQCLLCELGFLFDMLDKAKGATCQATNMLKMLTSHPGVGNlHLLEDDPHaSSL 587
           9*****************************5555554......467***********999999999**********988776554556666662468 PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.....slq 188
           a ++++l + l                   ++ +++ k++ + +++++    + +  +kc +c +++ r ++ +   l  p+ +    +     s++
   Q: 588  AAMIQGLARFL-----------------LDQMCRDYMKTSPEVNVMEQATATTAQVLMKCMHCSSETARSSSSFVNDLVYPQMNYIRGRpptatSFS 667
           89999999999.................123345677889999************************777766555555554443222244555*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.....pfcts.......peekqk 273
           d+L++  ++e+       +c++c+++q    + ++k +P+vL  + +  + ++++       +   +p+e+ +       +c +        +++++
   Q: 668  DILKKSIEREQTAR---GWCTTCRGYQPLATRKTIKAIPQVLAANANISTADQKR----LWATPGWLPEEIGVIigdehVYCFEgedlklhLQRAKH 757
           ***********995...9************************9988877555442....23333333333333322221233332222222223344 PP
   S: 274  ekkkYeLiavvvH..sGslssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
           e + Y+Li+vvv    G +++ H +++v+         e+ +W lf+D  V++v+ +e l+++   +t+ +++Y+
   Q: 758  EIYVYSLIGVVVNidRGPPHKPHLISMVNVahsapvppEDSQWHLFNDFLVKPVSSKEALTFNTtwKTPLIVLYQ 832
           59*********9722568999********9999999988999*******************98899999999998 PP

Organism

Gaeumannomyces graminis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDADWGEVTR FHFQQQRADS FLHSTIPTAI AFDTGAELLW VGQDFGRVAS FFHNGNKEME 60
RYTAFKASPH NQGAVRQFLF NDRGVICLSP QSVHMALRRG PPLWHINHED MKDLRCMSFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATCCTTGG AATTTGCACC AGGTCTGAAC TGACAAACGA AGCTCTGCAT CATCCCGCCC 60
GGCATCATCA TCCATGCTCC ACTGTTAGAT CAGGCCGTTG ATCATTGGGA ACTCCCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.24	3.00e-141	494.00
IUUC-Apl-003500	Anas platyrhynchos	30.94	2.00e-120	425.00
IUUC-Aca-004930	Anolis carolinensis	31.58	3.00e-140	491.00
IUUC-Acl-008214	Aspergillus clavatus	46.32	0.00e+00	1017.00
IUUC-Afu-009112	Aspergillus fumigatus	46.86	0.00e+00	1007.00
IUUC-Ang-009531	Aspergillus niger	47.41	0.00e+00	993.00
IUUC-Ame-011259	Astyanax mexicanus	46.74	2.00e-69	256.00
IUUC-Bta-012371	Bos taurus	32.15	2.00e-140	492.00
IUUC-Bci-013684	Botrytis cinerea	51.13	0.00e+00	1147.00
IUUC-Cja-019297	Callithrix jacchus	30.97	2.00e-134	472.00
IUUC-Cfa-020489	Canis familiaris	32.24	2.00e-139	488.00
IUUC-Cpo-022392	Cavia porcellus	31.85	2.00e-137	482.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.89	2.00e-138	485.00
IUUC-Csv-025841	Ciona savignyi	34.36	8.00e-61	227.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	59.27	0.00e+00	1392.00
IUUC-Cne-026932	Cryptococcus neoformans	32.67	3.00e-150	525.00
IUUC-Dre-028482	Danio rerio	45.19	7.00e-70	257.00
IUUC-Dno-029398	Dasypus novemcinctus	32.21	1.00e-138	486.00
IUUC-Dor-030307	Dipodomys ordii	33.91	7.00e-96	344.00
IUUC-Dme-032111	Drosophila melanogaster	27.18	2.00e-68	252.00
IUUC-Eca-033985	Equus caballus	32.07	9.00e-140	489.00
IUUC-Eeu-034928	Erinaceus europaeus	26.61	4.00e-24	105.00
IUUC-Fca-035587	Felis catus	32.15	3.00e-142	498.00
IUUC-Fal-037587	Ficedula albicollis	31.73	4.00e-140	491.00
IUUC-Fso-038133	Fusarium solani	51.66	0.00e+00	1137.00
IUUC-Gmo-039076	Gadus morhua	44.94	1.00e-68	253.00
IUUC-Gga-040948	Gallus gallus	31.92	8.00e-139	486.00
IUUC-Gac-042396	Gasterosteus aculeatus	47.28	3.00e-69	255.00
IUUC-Ggo-045412	Gorilla gorilla	31.89	9.00e-138	483.00
IUUC-Hsa-046076	Homo sapiens	31.98	7.00e-139	486.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.36	2.00e-121	429.00
IUUC-Kpa-049178	Komagataella pastoris	31.46	1.00e-160	559.00
IUUC-Lch-050279	Latimeria chalumnae	35.40	6.00e-77	281.00
IUUC-Loc-052872	Lepisosteus oculatus	29.06	3.00e-70	258.00
IUUC-Lma-052986	Leptosphaeria maculans	48.72	0.00e+00	1047.00
IUUC-Laf-054181	Loxodonta africana	31.84	7.00e-136	477.00
IUUC-Mcc-054812	Macaca mulatta	31.89	6.00e-138	483.00
IUUC-Meu-056325	Macropus eugenii	32.38	7.00e-139	486.00
IUUC-Mor-057246	Magnaporthe oryzae	58.60	0.00e+00	1328.00
IUUC-Mpo-057464	Magnaporthe poae	95.42	0.00e+00	2225.00
IUUC-Mla-058911	Melampsora laricipopulina	39.04	1.00e-118	419.00
IUUC-Mga-059335	Meleagris gallopavo	32.03	1.00e-137	482.00
IUUC-Mvi-060461	Microbotryum violaceum	35.65	2.00e-178	618.00
IUUC-Mmr-060636	Microcebus murinus	32.07	8.00e-138	483.00
IUUC-Mmu-063503	Mus musculus	32.41	3.00e-141	494.00
IUUC-Mpu-066670	Mustela putorius furo	32.07	6.00e-139	487.00
IUUC-Mlu-068119	Myotis lucifugus	31.83	3.00e-145	508.00
IUUC-Nfi-068398	Neosartorya fischeri	47.30	0.00e+00	1028.00
IUUC-Ncr-068927	Neurospora crassa	50.87	0.00e+00	1065.00
IUUC-Nle-069651	Nomascus leucogenys	30.86	1.00e-129	456.00
IUUC-Opr-070614	Ochotona princeps	31.29	4.00e-140	491.00
IUUC-Ont-072433	Oreochromis niloticus	48.29	2.00e-72	265.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.33	6.00e-63	234.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.62	5.00e-136	477.00
IUUC-Ola-087522	Oryzias latipes	31.14	5.00e-136	477.00
IUUC-Oga-088226	Otolemur garnettii	31.87	2.00e-138	485.00
IUUC-Oar-089241	Ovis aries	32.07	2.00e-143	501.00
IUUC-Pan-092297	Papio anubis	32.45	2.00e-131	462.00
IUUC-Psi-094043	Pelodiscus sinensis	31.27	7.00e-127	447.00
IUUC-Pma-094394	Petromyzon marinus	29.76	6.00e-71	261.00
IUUC-Pno-095053	Phaeosphaeria nodorum	47.67	0.00e+00	962.00
IUUC-Ppa-095188	Physcomitrella patens	26.88	6.00e-64	238.00
IUUC-Pfo-097517	Poecilia formosa	31.46	4.00e-140	491.00
IUUC-Pca-100471	Procavia capensis	31.99	2.00e-137	482.00
IUUC-Pva-102805	Pteropus vampyrus	30.35	2.00e-107	382.00
IUUC-Pte-104021	Pyrenophora teres	47.67	0.00e+00	1043.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	47.58	0.00e+00	1034.00
IUUC-Rno-105471	Rattus norvegicus	32.13	1.00e-140	493.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.91	1.00e-120	426.00
IUUC-Sha-106883	Sarcophilus harrisii	32.26	6.00e-133	467.00
IUUC-Spo-108169	Schizosaccharomyces pombe	36.38	0.00e+00	664.00
IUUC-Sar-113323	Sorex araneus	33.41	4.00e-114	404.00
IUUC-Sre-115075	Sporisorium reilianum	42.52	1.00e-65	243.00
IUUC-Ssc-116363	Sus scrofa	31.53	6.00e-139	487.00
IUUC-Tru-118427	Takifugu rubripes	47.26	5.00e-71	261.00
IUUC-Tni-120218	Tetraodon nigroviridis	47.60	9.00e-72	263.00
IUUC-Tre-122177	Trichoderma reesei	58.36	0.00e+00	1331.00
IUUC-Tme-127176	Tuber melanosporum	42.72	0.00e+00	830.00
IUUC-Tbe-127641	Tupaia belangeri	22.88	1.00e-20	94.40
IUUC-Ttr-128888	Tursiops truncatus	36.34	9.00e-106	377.00
IUUC-Uma-129361	Ustilago maydis	43.15	6.00e-64	238.00
IUUC-Xtr-132811	Xenopus tropicalis	31.12	2.00e-130	459.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence