iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Uma-129361

Ensembl Protein ID

KIS67494

UniProt Accession

A0A0D1DT60; A0A0D1DT60_USTMA

Genbank Protein ID

KIS67494.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

CM003152

Gene Name

PAN2; UMAG_04591

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
UMAG_04591	KIS67494	KIS67494

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.70e-11	40.2	612	1138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..gyeqqDaqEflaf 98
           Gl+ +    Y NS LQ+L+ ++++re  + +  +++++e      ++ll++   lf+ l + k  + + +++l+a+++ ++ +s   ++ +D++  ++ 
   Q: 612  GLETHIQNSYANSYLQALHYLTPFRETAKAHILHDCPRE------NCLLCEAGFLFRMLEDAKGANCQASNFLRAFGNSHKAVSlgLMDREDSSTNMSS 704
           777777788*********************888888876......59********************************99988878999999999999 PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsde..........................................................aeekkkkknk 139
             ++ ++e+  ++  ++ + +  d+++ + +                                                            +++    +
   Q: 705  AASAGKNEIVYSQLVQTLNRFVLDETANEAQvspggssarnatgsnsgstrasgtgappglgpplssnrggggagrrlagdsspstsllPADNPAFAAD 803
           9999999994433333333333333333333567888888999999**************************************999998899999999 PP
   S: 140  slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....slqdcLesftkeeelegenkyycekckkkqe...aekklklkklPevLi 231
           s++ +lF     ++++c +c+++++r  p l++ l  p+++ ++++    ++ ++L++   +e  +      c+ c+        + +   ++lP++L+
   Q: 804  SPVAKLFALNAVTKTVCIHCGRETNRPTPLLSVDLIYPRRSMSNESappsDFASVLRASLVREVQNR---APCRACQFTAMfrtRRVMPATSELPRILS 899
           ***********************************99988776666555577777777777776664...77777775544221455567899****** PP
   S: 232  lhLkRf.....sfseeqksrekinkkve..........fpleLdlspfctspeekqke......................................... 274
           ++ +       ++    + +   +   +           p++               +                                         
   Q: 900  VNASIQapehlHY----WLDDNQKGGNKapplgparpnGPQQ---------------Qaysklaymsmhgsnahnnarggagggllnaprtdtklasaa 979
           9987763322211....2222222222222333333331122...............111223333333344444667888888888888888888899 PP
   S: 275  ............................................kkkYeLiavvvHsG.slssGHYvayvkn........................... 301
                                                       +  Y+L ++vv      ++ H +a+v+                            
   Q: 980  sagdakrtylppriaigvygddvrvmpiytaadverartslggrPAMYKLRSMVVQISaDKEQPHLCAFVRVpeaetsvqgsngdgtastaattpkmsh 1078
           99999999999999999999999999999999999999999999*********999999**************************************** PP
   S: 302  .....................ekgk...WllfdDskVtevkeeevleetg..staYvlfYkr 337
                                +  +   W+lf+D  V+ v+++e l +++  + + vl+++r
   Q: 1079 atgaaaglalgsskksarakaN--QlgpWYLFNDFLVRNVSKHEALGFQNtwKMPSVLMWER 1138
           9999999999999888876441..3567**************99998877777777777765 PP

Organism

Ustilago maydis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MADWSEHAHY GNPNGPMGLP PAVTALTFDP YHELLWQGTS FGTVSSLYSA QLSRYTSYAA 60
HGVPTRPSPT KNILADERHI FSLSDNGIKC SQRRGLAKWS TLTDDLGTNA MNLVSMCASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGACT GGAGCGAGCA TGCCCACTAT GGCAACCCCA ATGGGCCCAT GGGCCTTCCA 60
CCAGCCGTCA CTGCGCTCAC ATTCGACCCC TACCATGAGC TTCTCTGGCA GGGCACCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

uma:UMAG_04591

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	41.28	4.00e-71	261.00
IUUC-Apl-003500	Anas platyrhynchos	49.38	9.00e-65	240.00
IUUC-Aca-004930	Anolis carolinensis	41.43	6.00e-70	258.00
IUUC-Acl-008214	Aspergillus clavatus	42.98	1.00e-74	273.00
IUUC-Afu-009112	Aspergillus fumigatus	42.14	2.00e-73	269.00
IUUC-Ang-009531	Aspergillus niger	42.14	8.00e-73	267.00
IUUC-Ame-011259	Astyanax mexicanus	41.35	5.00e-71	261.00
IUUC-Bta-012371	Bos taurus	41.28	4.00e-71	261.00
IUUC-Bci-013684	Botrytis cinerea	39.07	4.00e-63	234.00
IUUC-Cel-018293	Caenorhabditis elegans	32.89	1.00e-04	39.30
IUUC-Cja-019297	Callithrix jacchus	41.57	2.00e-71	262.00
IUUC-Cfa-020489	Canis familiaris	41.28	3.00e-71	261.00
IUUC-Cpo-022392	Cavia porcellus	41.28	8.00e-71	260.00
IUUC-Csa-023220	Chlorocebus sabaeus	41.57	2.00e-71	262.00
IUUC-Csv-025841	Ciona savignyi	43.35	9.00e-63	233.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	43.23	2.00e-72	266.00
IUUC-Cne-026932	Cryptococcus neoformans	42.55	7.00e-85	307.00
IUUC-Dre-028482	Danio rerio	41.35	1.00e-70	260.00
IUUC-Dno-029398	Dasypus novemcinctus	41.35	1.00e-70	260.00
IUUC-Dor-030307	Dipodomys ordii	45.95	2.00e-53	202.00
IUUC-Dme-032111	Drosophila melanogaster	38.38	4.00e-66	244.00
IUUC-Eca-033985	Equus caballus	41.28	5.00e-71	261.00
IUUC-Eeu-034928	Erinaceus europaeus	27.39	5.00e-29	122.00
IUUC-Fca-035587	Felis catus	41.28	6.00e-71	261.00
IUUC-Fal-037587	Ficedula albicollis	41.14	1.00e-69	256.00
IUUC-Fso-038133	Fusarium solani	44.38	4.00e-76	278.00
IUUC-Gmo-039076	Gadus morhua	41.69	2.00e-70	259.00
IUUC-Ggr-039957	Gaeumannomyces graminis	43.15	8.00e-63	234.00
IUUC-Gga-040948	Gallus gallus	42.15	3.00e-70	259.00
IUUC-Gac-042396	Gasterosteus aculeatus	41.11	6.00e-70	257.00
IUUC-Ggo-045412	Gorilla gorilla	41.57	2.00e-71	263.00
IUUC-Hsa-046076	Homo sapiens	41.57	2.00e-71	263.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	36.34	3.00e-55	208.00
IUUC-Kpa-049178	Komagataella pastoris	40.83	1.00e-66	247.00
IUUC-Lch-050279	Latimeria chalumnae	41.28	1.00e-69	256.00
IUUC-Loc-052872	Lepisosteus oculatus	41.86	1.00e-68	253.00
IUUC-Lma-052986	Leptosphaeria maculans	43.82	2.00e-69	256.00
IUUC-Laf-054181	Loxodonta africana	41.64	1.00e-73	270.00
IUUC-Mcc-054812	Macaca mulatta	41.57	2.00e-71	262.00
IUUC-Meu-056325	Macropus eugenii	40.99	1.00e-69	256.00
IUUC-Mor-057246	Magnaporthe oryzae	38.87	5.00e-53	201.00
IUUC-Mpo-057464	Magnaporthe poae	42.26	1.00e-67	250.00
IUUC-Mla-058911	Melampsora laricipopulina	39.14	4.00e-108	384.00
IUUC-Mga-059335	Meleagris gallopavo	43.04	4.00e-68	251.00
IUUC-Mvi-060461	Microbotryum violaceum	43.88	1.00e-87	317.00
IUUC-Mmr-060636	Microcebus murinus	41.57	2.00e-71	262.00
IUUC-Mmu-063503	Mus musculus	41.28	8.00e-71	260.00
IUUC-Mpu-066670	Mustela putorius furo	41.28	4.00e-71	261.00
IUUC-Mlu-068119	Myotis lucifugus	41.06	2.00e-72	266.00
IUUC-Nfi-068398	Neosartorya fischeri	42.14	4.00e-73	268.00
IUUC-Ncr-068927	Neurospora crassa	42.35	7.00e-71	261.00
IUUC-Nle-069651	Nomascus leucogenys	41.06	4.00e-72	265.00
IUUC-Opr-070614	Ochotona princeps	41.57	4.00e-71	261.00
IUUC-Ont-072433	Oreochromis niloticus	41.81	9.00e-72	263.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.23	2.00e-65	242.00
IUUC-Ocu-074401	Oryctolagus cuniculus	41.57	2.00e-71	263.00
IUUC-Ola-087522	Oryzias latipes	41.81	4.00e-72	265.00
IUUC-Oga-088226	Otolemur garnettii	41.57	2.00e-71	262.00
IUUC-Oar-089241	Ovis aries	41.35	1.00e-72	266.00
IUUC-Pan-092297	Papio anubis	41.57	2.00e-71	262.00
IUUC-Psi-094043	Pelodiscus sinensis	42.11	8.00e-61	227.00
IUUC-Pma-094394	Petromyzon marinus	43.70	1.00e-73	269.00
IUUC-Pno-095053	Phaeosphaeria nodorum	42.65	3.00e-69	254.00
IUUC-Ppa-095188	Physcomitrella patens	34.73	6.00e-61	228.00
IUUC-Pfo-097517	Poecilia formosa	42.11	3.00e-72	265.00
IUUC-Pca-100471	Procavia capensis	41.35	8.00e-73	267.00
IUUC-Pva-102805	Pteropus vampyrus	41.28	7.00e-71	261.00
IUUC-Pte-104021	Pyrenophora teres	43.19	5.00e-70	258.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	43.44	6.00e-70	257.00
IUUC-Rno-105471	Rattus norvegicus	42.15	5.00e-71	261.00
IUUC-Sce-106235	Saccharomyces cerevisiae	39.05	5.00e-62	231.00
IUUC-Sha-106883	Sarcophilus harrisii	40.99	8.00e-70	257.00
IUUC-Spo-108169	Schizosaccharomyces pombe	36.52	6.00e-82	297.00
IUUC-Sar-113323	Sorex araneus	42.15	2.00e-71	263.00
IUUC-Sre-115075	Sporisorium reilianum	79.19	0.00e+00	2152.00
IUUC-Ssc-116363	Sus scrofa	41.35	1.00e-72	266.00
IUUC-Tru-118427	Takifugu rubripes	41.81	2.00e-71	262.00
IUUC-Tni-120218	Tetraodon nigroviridis	41.52	2.00e-71	262.00
IUUC-Tre-122177	Trichoderma reesei	44.08	7.00e-75	274.00
IUUC-Tme-127176	Tuber melanosporum	43.92	5.00e-75	274.00
IUUC-Tbe-127641	Tupaia belangeri	31.38	3.00e-22	99.40
IUUC-Ttr-128888	Tursiops truncatus	40.70	7.00e-67	247.00
IUUC-Xtr-132811	Xenopus tropicalis	41.86	1.00e-71	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence