iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017619

Ensembl Protein ID

Bra001797.1-P

UniProt Accession

M4CC67; M4CC67_BRARP

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra001797	Bra001797.1	Bra001797.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-52	179.7	331	817
UBD/Alpha-Helix/UBA	4.40e-17	62.6	636	676

Active Site

Position(s)	Description	Evidence
340	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
780	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklnee.npkepkgellkslqklfeel...............w.kskkkavsprellkalkk 79
           tGl NlgN+CY+ +++Q L++++++ + ++++++ kl+ e +p +p+ ++ ++l+kl + l               + + +++ + pr++++++++
   Q: 331  TGLVNLGNSCYLAATMQILFSTHSFISRYFSHQSLKLAFEmAPADPTLDINMQLTKLGHGLlsgkysipvaekdvaTgDVRQEGIPPRMFKSVVAA 426
           7*************************9999977777765515689999*************6666666665555432577777************* PP
   S: 80   eaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlsl 174
            + efs+++qqDa +f+ +lld++e+                             +++ +   s+ F++ ++++i c + + ++ +r++  l+l++
   Q: 427  GHAEFSSMRQQDALDFFLHLLDKVERGN---------------------------NMRPDLDPSRSFKFGVEEKILCSSGKVSYnKRDDCILSLNI 495
           *************************988...........................5678888999************7765555444455555555 PP
   S: 175  pvpgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
           p+++ +  +k                               l+ cL+ f+++e++++   yy++  k+k++a k+++l+++P++L+lh+ +f + e
   Q: 496  PLQEAT--NKDeleafnnqkadkgleednmstdeivrprvPLEACLATFSSPEQIRD---YYSTALKGKTTAIKTTSLTSFPDYLVLHMRKF-VME 585
           555555..444569*****************************************97...********************************.778 PP
   S: 242  eqksrekinkkvefpleLdlspfcts...................................................................... 267
           ++++++k++ ++++p+ +d+s++ ++                                                                      
   Q: 586  AGWVPKKLDVYIDVPDVIDISHMRSKglqpgeellpddvpeeamesaqpvaneeivaqlvsmgfsqlhcqkaaintsntgveeamtwllshmddpd 681
           89*******************999999999999999999888888888888888888888888888888777777777777777777777777777 PP
   S: 268  .................peekqke...........................................................kkkYeLiavvvHs 287
                            +     +                                                             +Y+L+++v+H 
   Q: 682  idapisnqtsdvdqssvD-----TlisfgfaeevarkalkasggdiekatdwifnnpnasisdmdvsssnsaqtpaqselpdgGGRYKLFGIVSHI 772
           777666665555555550.....0555555555555555555555555666666666666666666666667778888888889************ PP
   S: 288  G.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           G s+++GHYva++ + +g+W+ f+DskV ++  ++  +   + +Y++f++r
   Q: 773  GtSTHCGHYVAHILK-EGRWVIFNDSKVGVS--TNPPK---DMGYLYFFQR 817
           ***************.9***********999..57777...8999999987 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++e++++qlv+MGF++ ++++a  ++ n  +e+A+++Ll++
   Q: 636  ANEEIVAQLVSMGFSQLHCQKAAINTsNTGVEEAMTWLLSH 676
           589************************************97 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MELLRSNLSR VQIPEPTHRI YKHECCLSFD TPVKPLSFDT PFIWRRLFDS VYDFQRSEGG 60
LFVDMNSFLA FGKDYVSWNY EKTRNPVYLH IKESPKSVPE DRPLKKPTLL AIGVDGGFDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTCC TCCGATCAAA CTTGTCTAGG GTTCAGATCC CGGAGCCCAC CCACCGCATC 60
TACAAGCACG AGTGCTGCCT CTCCTTCGAC ACTCCGGTAA AACCTCTCTC CTTCGACACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	63.81	0.00e+00	998.00
IUUC-Atr-002580	Amborella trichopoda	64.55	0.00e+00	1139.00
IUUC-Apl-003774	Anas platyrhynchos	48.48	0.00e+00	750.00
IUUC-Acl-008057	Aspergillus clavatus	35.35	9.00e-121	427.00
IUUC-Afl-008547	Aspergillus flavus	37.39	5.00e-117	414.00
IUUC-Afu-008805	Aspergillus fumigatus	34.42	2.00e-111	396.00
IUUC-Ani-009441	Aspergillus nidulans	34.58	2.00e-97	350.00
IUUC-Bol-015296	Brassica oleracea	95.12	0.00e+00	1560.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.63	2.00e-118	419.00
IUUC-Cho-024522	Choloepus hoffmanni	35.62	8.00e-124	437.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.05	2.00e-109	389.00
IUUC-Cne-026831	Cryptococcus neoformans	35.86	1.00e-122	433.00
IUUC-Cme-027335	Cyanidioschyzon merolae	34.71	3.00e-39	157.00
IUUC-Eeu-035304	Erinaceus europaeus	49.42	0.00e+00	689.00
IUUC-Fal-037271	Ficedula albicollis	49.68	0.00e+00	738.00
IUUC-Fso-038158	Fusarium solani	34.58	2.00e-120	426.00
IUUC-Mor-057106	Magnaporthe oryzae	34.17	1.00e-120	427.00
IUUC-Mpo-057589	Magnaporthe poae	34.57	1.00e-117	417.00
IUUC-Mtr-058680	Medicago truncatula	73.61	0.00e+00	1234.00
IUUC-Mga-059669	Meleagris gallopavo	48.13	0.00e+00	744.00
IUUC-Mac-065634	Musa acuminata	64.74	0.00e+00	1139.00
IUUC-Nfi-068558	Neosartorya fischeri	35.59	4.00e-123	435.00
IUUC-Ncr-068960	Neurospora crassa	32.54	3.00e-108	386.00
IUUC-Oan-072959	Ornithorhynchus anatinus	53.72	1.00e-71	262.00
IUUC-Pma-094242	Petromyzon marinus	49.35	1.00e-106	379.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.25	2.00e-107	383.00
IUUC-Pca-100738	Procavia capensis	46.28	3.00e-149	522.00
IUUC-Sce-106304	Saccharomyces cerevisiae	30.92	1.00e-67	250.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.85	2.00e-97	349.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.57	2.00e-112	400.00
IUUC-Sar-113733	Sorex araneus	45.99	1.00e-93	337.00
IUUC-Sre-115225	Sporisorium reilianum	32.21	4.00e-109	389.00
IUUC-Tbe-127261	Tupaia belangeri	41.79	2.00e-124	439.00
IUUC-Uma-129599	Ustilago maydis	33.11	4.00e-118	418.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence