iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068960

Ensembl Protein ID

EAA30801

UniProt Accession

Q7S5R6; Q7S5R6_NEUCR

Genbank Protein ID

EAA30801.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CM002242

Gene Name

NCU05777

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU05777	EAA30801	EAA30801

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-52	177.7	302	787
UBD/Alpha-Helix/UBA	4.10e-15	54.4	589	627

Active Site

Position(s)	Description	Evidence
311	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
743	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkk...................avsprellkalkk 79
           tGlkNlgN+CY+ S+LQcL+ +p++++ + + k   l+    ++p ++l ++l+kl   l+   +   +                     +p+++++ +++
   Q: 302  TGLKNLGNSCYLASILQCLYDLPSFQQRYYSDKLGPLPSV--SDPAEDLETQLRKLGDGLLsgrY---SksdadvfasehtpnvpyqkGLQPSMFKHLMGR 397
           7******************************888888776..78999999999999999963321...22334566666666666666************* PP
   S: 80   eaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
            +eefs+++qqDa E+l++l++ + ++                            +  +    ++ +++ ++++++cl+c++v  + ++  ++ ++vp+++
   Q: 398  GHEEFSTMRQQDAFELLQHLIKLITRSK---------------------------HPVELGDPTQPMRFVMEQRLQCLNCKKVRYSSNEQDSVFIDVPMEK 471
           **********************999877...........................556666788999*****************88888899999999888 PP
   S: 181  etkke..........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts... 267
              +e          +l++cL+s t+ e +e    + c  c +k   +k+  +k++P+vL+++  ++     ++++ ki+  v + +e L+l++++++   
   Q: 472  LPPEEegqepkykpvTLKQCLDSLTASEVVE----LTCAGCGSKDGFTKRQAFKTFPDVLVVNARKM--AVVNWVPVKIDVPVIVDDEpLNLDEYLSKgqq 566
           765558888899999***************9....9*******************************..6678*************************555 PP
   S: 268  ..peekqke............................................................................................ 274
             +     e                                                                                            
   Q: 567  pdE-----Ealpedesakssapafvpnaealamleamgfprvrgekalhatgnsdanaamewlfahmddpdidvpldlsassggaasggagaadpeklaml 662
           550.....345555555555566666666666666666666666666666666666666666666666666666666666666666666666777777777 PP
   S: 275  ............................................................kkkYeLiavvvHsG.slssGHYvayvkn....ekgkWllfd 310
                                                                       + k++L ++v+H+G s++ GHYva++++    ++ +W+lf+
   Q: 663  esmglsgpravkalnetggdveraiewlfshpdddgadaveeeapagnegpkkeagsselPAKFQLQSIVCHKGtSIHAGHYVAFIRKklseDETSWVLFN 763
           777777777777777777777777777777777777777777777788888888888889****************************66555566***** PP
   S: 311  DskVtev.keeevleetgstaYvlfYkr 337
           D+kV +v + ee++    +taYv+f+kr
   Q: 764  DEKVVKVvDVEEMK----KTAYVYFFKR 787
           ***98881344444....6*******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
            ++l+ l++MGF+r +  +aL a+ n +++aA+e+L+ +
   Q: 589  AEALAMLEAMGFPRVRGEKALHATgNSDANAAMEWLFAH 627
           5789999*****************************976 PP

Organism

Neurospora crassa

Protein Sequence
(Fasta)

MSCPHIGSAN LAKPSPTDNV YREDCTQCFD SIDDPAGLDV CLKCFNGGCA GDRNHAKLHA 60
TSRNHPLVLN IRRTRKIIER NEPPLKMSKL AIAAETESDR YDTTLTVKCL DCGIDNLNKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACGGCAAG CTTCCATTTT CCTTCACGCT TCTTCCATCT TCTCTTCCTC TGCAATACAA 60
CTTCACTTGG CGGTAGACTT CATCCAACAA TTCGATGACT TTCTAGTTGT ACACAACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ncr:NCU05777

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	31.35	6.00e-88	317.00
IUUC-Aml-002104	Ailuropoda melanoleuca	35.17	5.00e-124	437.00
IUUC-Atr-002580	Amborella trichopoda	32.72	2.00e-104	371.00
IUUC-Apl-003774	Anas platyrhynchos	35.11	2.00e-118	418.00
IUUC-Aca-005368	Anolis carolinensis	35.74	7.00e-127	446.00
IUUC-Aly-005727	Arabidopsis lyrata	34.46	2.00e-112	398.00
IUUC-Ath-006974	Arabidopsis thaliana	34.58	3.00e-113	400.00
IUUC-Ago-007890	Ashbya gossypii	31.71	6.00e-101	360.00
IUUC-Acl-008057	Aspergillus clavatus	58.87	0.00e+00	898.00
IUUC-Afl-008547	Aspergillus flavus	60.09	0.00e+00	809.00
IUUC-Afu-008805	Aspergillus fumigatus	54.35	0.00e+00	791.00
IUUC-Ani-009441	Aspergillus nidulans	54.43	0.00e+00	734.00
IUUC-Ang-009720	Aspergillus niger	58.17	0.00e+00	895.00
IUUC-Aor-010111	Aspergillus oryzae	60.33	0.00e+00	972.00
IUUC-Ate-010531	Aspergillus terreus	56.01	0.00e+00	839.00
IUUC-Ame-011893	Astyanax mexicanus	34.96	2.00e-101	362.00
IUUC-Bgr-012183	Blumeria graminis	59.95	0.00e+00	949.00
IUUC-Bta-013179	Bos taurus	35.10	2.00e-122	431.00
IUUC-Bci-013858	Botrytis cinerea	65.62	0.00e+00	1048.00
IUUC-Bdi-014904	Brachypodium distachyon	33.01	6.00e-93	333.00
IUUC-Bol-015296	Brassica oleracea	33.78	3.00e-111	394.00
IUUC-Bra-017619	Brassica rapa	33.57	8.00e-111	392.00
IUUC-Cel-018625	Caenorhabditis elegans	30.75	4.00e-79	287.00
IUUC-Cja-019063	Callithrix jacchus	34.79	2.00e-120	425.00
IUUC-Cfa-020976	Canis familiaris	35.84	7.00e-127	446.00
IUUC-Cpo-022265	Cavia porcellus	35.45	3.00e-125	441.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	33.78	1.00e-60	226.00
IUUC-Csa-024177	Chlorocebus sabaeus	34.82	1.00e-115	408.00
IUUC-Cho-024702	Choloepus hoffmanni	33.16	7.00e-76	276.00
IUUC-Cin-025411	Ciona intestinalis	33.57	3.00e-100	358.00
IUUC-Csv-026347	Ciona savignyi	31.83	3.00e-95	341.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	70.53	0.00e+00	1053.00
IUUC-Cne-026831	Cryptococcus neoformans	47.31	0.00e+00	634.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.04	9.00e-79	286.00
IUUC-Dre-027982	Danio rerio	33.41	6.00e-103	367.00
IUUC-Dno-029034	Dasypus novemcinctus	35.33	2.00e-125	441.00
IUUC-Dor-030479	Dipodomys ordii	35.05	1.00e-55	209.00
IUUC-Dse-031467	Dothistroma septosporum	56.17	0.00e+00	871.00
IUUC-Dme-032075	Drosophila melanogaster	34.00	5.00e-105	373.00
IUUC-Ete-032865	Echinops telfairi	31.53	9.00e-100	356.00
IUUC-Eca-034059	Equus caballus	35.10	4.00e-123	433.00
IUUC-Eeu-035304	Erinaceus europaeus	37.59	7.00e-113	399.00
IUUC-Fca-035515	Felis catus	35.10	2.00e-124	437.00
IUUC-Fal-037271	Ficedula albicollis	35.60	3.00e-116	410.00
IUUC-Fox-037745	Fusarium oxysporum	71.14	0.00e+00	1102.00
IUUC-Fso-038158	Fusarium solani	72.10	0.00e+00	1115.00
IUUC-Gmo-039071	Gadus morhua	33.57	1.00e-105	375.00
IUUC-Ggr-040098	Gaeumannomyces graminis	72.86	0.00e+00	1093.00
IUUC-Gga-040635	Gallus gallus	34.76	8.00e-122	429.00
IUUC-Gac-042528	Gasterosteus aculeatus	35.49	9.00e-110	389.00
IUUC-Gma-043614	Glycine max	32.56	2.00e-102	364.00
IUUC-Ggo-044602	Gorilla gorilla	35.10	1.00e-123	436.00
IUUC-Hsa-045959	Homo sapiens	35.10	1.00e-123	436.00
IUUC-Hvu-047563	Hordeum vulgare	35.36	8.00e-93	332.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	35.06	4.00e-124	437.00
IUUC-Kpa-049156	Komagataella pastoris	40.15	2.00e-168	583.00
IUUC-Lch-049648	Latimeria chalumnae	34.60	3.00e-114	404.00
IUUC-Lpe-051523	Leersia perrieri	31.68	7.00e-94	336.00
IUUC-Loc-052072	Lepisosteus oculatus	31.10	2.00e-103	368.00
IUUC-Lma-053216	Leptosphaeria maculans	62.44	0.00e+00	938.00
IUUC-Laf-054327	Loxodonta africana	34.98	7.00e-123	432.00
IUUC-Mcc-055443	Macaca mulatta	35.10	4.00e-124	437.00
IUUC-Meu-056298	Macropus eugenii	34.58	2.00e-83	302.00
IUUC-Mor-057106	Magnaporthe oryzae	71.37	0.00e+00	1137.00
IUUC-Mpo-057589	Magnaporthe poae	72.61	0.00e+00	1095.00
IUUC-Mtr-058680	Medicago truncatula	33.29	2.00e-107	381.00
IUUC-Mla-058903	Melampsora laricipopulina	43.60	0.00e+00	634.00
IUUC-Mga-059669	Meleagris gallopavo	34.43	8.00e-116	409.00
IUUC-Mvi-060476	Microbotryum violaceum	44.25	3.00e-173	600.00
IUUC-Mmr-060575	Microcebus murinus	35.10	4.00e-123	434.00
IUUC-Mdo-062183	Monodelphis domestica	35.79	3.00e-124	437.00
IUUC-Mmu-063592	Mus musculus	34.98	2.00e-123	434.00
IUUC-Mac-065446	Musa acuminata	31.05	3.00e-92	331.00
IUUC-Mpu-066082	Mustela putorius furo	35.72	6.00e-127	446.00
IUUC-Mlu-067345	Myotis lucifugus	35.47	1.00e-124	439.00
IUUC-Nfi-068558	Neosartorya fischeri	57.41	0.00e+00	859.00
IUUC-Nle-070173	Nomascus leucogenys	35.49	2.00e-125	441.00
IUUC-Opr-070556	Ochotona princeps	35.41	7.00e-124	436.00
IUUC-Ont-071502	Oreochromis niloticus	35.49	6.00e-110	389.00
IUUC-Oan-072959	Ornithorhynchus anatinus	40.53	1.00e-45	174.00
IUUC-Ocu-074861	Oryctolagus cuniculus	35.86	3.00e-125	441.00
IUUC-Oba-075109	Oryza barthii	31.46	5.00e-96	343.00
IUUC-Obr-076292	Oryza brachyantha	32.64	2.00e-94	338.00
IUUC-Ogl-077065	Oryza glaberrima	32.44	4.00e-103	367.00
IUUC-Ogu-078776	Oryza glumaepatula	31.94	2.00e-100	358.00
IUUC-Oin-080048	Oryza indica	32.31	1.00e-101	362.00
IUUC-Olo-080711	Oryza longistaminata	31.06	1.00e-89	322.00
IUUC-Ome-081506	Oryza meridionalis	31.74	5.00e-91	327.00
IUUC-Oni-082320	Oryza nivara	30.98	2.00e-95	341.00
IUUC-Opu-083801	Oryza punctata	31.53	1.00e-90	325.00
IUUC-Oru-085139	Oryza rufipogon	31.10	4.00e-95	340.00
IUUC-Osa-085713	Oryza sativa	32.56	6.00e-104	370.00
IUUC-Ola-086951	Oryzias latipes	33.61	7.00e-104	370.00
IUUC-Olu-087822	Ostreococcus lucimarinus	31.09	3.00e-92	331.00
IUUC-Oga-088625	Otolemur garnettii	34.87	1.00e-122	432.00
IUUC-Oar-089995	Ovis aries	34.94	8.00e-123	432.00
IUUC-Ptr-090640	Pan troglodytes	35.70	4.00e-126	444.00
IUUC-Pan-091974	Papio anubis	35.02	1.00e-124	439.00
IUUC-Psi-093957	Pelodiscus sinensis	34.92	3.00e-123	434.00
IUUC-Pma-094242	Petromyzon marinus	39.58	4.00e-69	253.00
IUUC-Pno-094835	Phaeosphaeria nodorum	61.35	0.00e+00	863.00
IUUC-Ppa-095901	Physcomitrella patens	34.79	2.00e-115	408.00
IUUC-Pfo-097148	Poecilia formosa	35.41	7.00e-111	393.00
IUUC-Pab-098068	Pongo abelii	32.64	1.00e-103	369.00
IUUC-Pop-098943	Populus trichocarpa	32.37	2.00e-101	361.00
IUUC-Pca-100738	Procavia capensis	36.14	1.00e-89	322.00
IUUC-Ppe-101315	Prunus persica	32.34	3.00e-100	357.00
IUUC-Pva-102154	Pteropus vampyrus	34.75	4.00e-121	427.00
IUUC-Pgr-103343	Puccinia graminis	43.59	4.00e-151	526.00
IUUC-Ptt-103928	Puccinia triticina	36.82	8.00e-141	492.00
IUUC-Pte-104306	Pyrenophora teres	62.36	0.00e+00	912.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	62.13	0.00e+00	927.00
IUUC-Rno-105801	Rattus norvegicus	35.33	7.00e-125	439.00
IUUC-Sce-106304	Saccharomyces cerevisiae	34.02	1.00e-111	395.00
IUUC-Sha-107635	Sarcophilus harrisii	35.29	7.00e-123	432.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	41.21	2.00e-162	564.00
IUUC-Spo-108144	Schizosaccharomyces pombe	42.53	1.00e-172	598.00
IUUC-Smo-108703	Selaginella moellendorffii	36.03	8.00e-108	382.00
IUUC-Sit-110728	Setaria italica	32.39	6.00e-106	376.00
IUUC-Sly-111523	Solanum lycopersicum	33.78	6.00e-112	396.00
IUUC-Sar-113733	Sorex araneus	38.56	1.00e-59	223.00
IUUC-Sbi-114419	Sorghum bicolor	32.72	5.00e-103	367.00
IUUC-Sre-115225	Sporisorium reilianum	44.82	0.00e+00	631.00
IUUC-Ssc-115686	Sus scrofa	35.17	9.00e-124	436.00
IUUC-Tgu-117346	Taeniopygia guttata	34.03	3.00e-118	417.00
IUUC-Tru-118350	Takifugu rubripes	32.17	2.00e-104	371.00
IUUC-Tsy-119278	Tarsius syrichta	32.12	1.00e-84	305.00
IUUC-Tni-120658	Tetraodon nigroviridis	32.87	2.00e-100	358.00
IUUC-Tca-121585	Theobroma cacao	33.01	4.00e-103	367.00
IUUC-Tre-122043	Trichoderma reesei	70.78	0.00e+00	1061.00
IUUC-Tvi-122303	Trichoderma virens	70.20	0.00e+00	1056.00
IUUC-Tae-125686	Triticum aestivum	32.56	2.00e-100	358.00
IUUC-Tur-126732	Triticum urartu	31.17	2.00e-92	331.00
IUUC-Tme-126909	Tuber melanosporum	60.12	0.00e+00	913.00
IUUC-Tbe-127261	Tupaia belangeri	32.06	7.00e-70	256.00
IUUC-Ttr-129119	Tursiops truncatus	36.51	4.00e-59	221.00
IUUC-Uma-129599	Ustilago maydis	44.79	0.00e+00	651.00
IUUC-Vda-129688	Verticillium dahliae	69.41	0.00e+00	1051.00
IUUC-Vpa-130170	Vicugna pacos	37.93	2.00e-47	182.00
IUUC-Vvi-131116	Vitis vinifera	32.77	3.00e-101	360.00
IUUC-Xtr-131953	Xenopus tropicalis	34.06	5.00e-108	383.00
IUUC-Xma-133837	Xiphophorus maculatus	35.36	1.00e-110	392.00
IUUC-Yli-134510	Yarrowia lipolytica	43.15	1.00e-165	575.00
IUUC-Zma-135786	Zea mays	32.07	2.00e-96	344.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence