iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013259

Ensembl Protein ID

ENSBTAP00000010835.5

UniProt Accession

Q2LGB5; Q58D12; TOLIP_BOVIN

Genbank Protein ID

ABC47876.1; ABD72515.1; AAX46632.1; AAI23458.1

Protein Name

Toll-interacting protein

Genbank Nucleotide ID

DQ319073; DQ407275; BT021785; BC123457

Gene Name

TOLLIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008237.5	ENSBTAT00000010835.5	ENSBTAP00000010835.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	7.20e-15	54.7	229	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
            e++l++++++FPn+d +vi++vLea++gs +aa+n+LL++ 
   Q: 229  SEEDLKAIQDMFPNMDREVIRSVLEAQRGSRDAAINSLLQMG 270
           699*************************************96 PP

Organism

Bos taurus

Functional Description
(View)

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).

Protein Sequence
(Fasta)

MATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGALG TVGRLSVTVV 60
QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGACCGCC GTCTGGTCGC GTCTCTGTCA GCTGTCGGTG GGCTAGGCGC GGGGCCGGCC 60
GGACCATGGC GACCACCGTC AGCACGCAGC GCGGGCCGGT AGGCTCCGGC GGGGGCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000008--C2_dom
IPR003892--CUE
IPR009060--UBA-like

PROSITE

PS51140--CUE

Pfam

PF00168--C2
PF02845--CUE

SMART

SM00239--C2
SM00546--CUE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0006914--P:autophagy
GO:0030855--P:epithelial cell differentiation
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0016310--P:phosphorylation
GO:0036010--P:protein localization to endosome
GO:0007165--P:signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:539480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001566	Ailuropoda melanoleuca	90.11	3.00e-110	390.00
IUUC-Apl-003706	Anas platyrhynchos	85.04	5.00e-115	406.00
IUUC-Aca-004943	Anolis carolinensis	79.78	2.00e-103	368.00
IUUC-Ago-007813	Ashbya gossypii	29.13	8.00e-05	41.60
IUUC-Ame-011082	Astyanax mexicanus	81.82	3.00e-122	431.00
IUUC-Bgr-011976	Blumeria graminis	33.33	6.00e-03	35.40
IUUC-Bdi-014407	Brachypodium distachyon	36.59	1.00e-01	30.40
IUUC-Cel-018399	Caenorhabditis elegans	36.84	3.00e-45	174.00
IUUC-Cja-018753	Callithrix jacchus	90.41	4.00e-126	444.00
IUUC-Cfa-020087	Canis familiaris	90.69	1.00e-110	392.00
IUUC-Cpo-021735	Cavia porcellus	82.55	5.00e-114	403.00
IUUC-Csa-023623	Chlorocebus sabaeus	89.74	4.00e-123	433.00
IUUC-Cin-025139	Ciona intestinalis	39.89	4.00e-38	150.00
IUUC-Csv-025877	Ciona savignyi	37.67	3.00e-48	185.00
IUUC-Cme-027282	Cyanidioschyzon merolae	31.71	1.70e+00	26.60
IUUC-Dre-028691	Danio rerio	81.82	1.00e-111	395.00
IUUC-Dno-029753	Dasypus novemcinctus	86.08	2.00e-107	382.00
IUUC-Dor-030201	Dipodomys ordii	79.84	7.00e-90	323.00
IUUC-Dse-031373	Dothistroma septosporum	31.19	1.00e-06	48.90
IUUC-Ete-032378	Echinops telfairi	85.26	8.00e-93	333.00
IUUC-Eca-034156	Equus caballus	92.40	8.00e-120	422.00
IUUC-Fca-035386	Felis catus	88.26	4.00e-113	400.00
IUUC-Fal-036799	Ficedula albicollis	86.48	4.00e-120	423.00
IUUC-Gmo-038999	Gadus morhua	77.06	2.00e-113	401.00
IUUC-Gga-041068	Gallus gallus	89.05	3.00e-126	444.00
IUUC-Ggo-044809	Gorilla gorilla	74.45	4.00e-90	324.00
IUUC-Hsa-046654	Homo sapiens	89.74	4.00e-123	433.00
IUUC-Itr-048912	Ictidomys tridecemlineatus	92.40	9.00e-119	419.00
IUUC-Lch-049986	Latimeria chalumnae	83.94	5.00e-126	443.00
IUUC-Loc-052419	Lepisosteus oculatus	54.74	8.00e-59	219.00
IUUC-Lma-053222	Leptosphaeria maculans	41.67	1.50e-01	30.80
IUUC-Laf-053390	Loxodonta africana	90.49	2.00e-114	404.00
IUUC-Mcc-054649	Macaca mulatta	88.93	7.00e-116	409.00
IUUC-Meu-056690	Macropus eugenii	93.66	7.00e-72	263.00
IUUC-Mor-057041	Magnaporthe oryzae	47.06	1.30e-02	34.30
IUUC-Mga-059674	Meleagris gallopavo	85.04	4.00e-115	407.00
IUUC-Mvi-060273	Microbotryum violaceum	37.14	3.10e-01	28.50
IUUC-Mmr-060744	Microcebus murinus	90.15	7.00e-116	409.00
IUUC-Mdo-062591	Monodelphis domestica	87.23	5.00e-127	446.00
IUUC-Mmu-063685	Mus musculus	92.34	2.00e-124	437.00
IUUC-Mac-064554	Musa acuminata	27.20	4.00e-07	48.50
IUUC-Mpu-066005	Mustela putorius furo	89.73	5.00e-112	397.00
IUUC-Ncr-068740	Neurospora crassa	40.38	2.00e-03	37.40
IUUC-Nle-069520	Nomascus leucogenys	89.74	4.00e-123	433.00
IUUC-Opr-071036	Ochotona princeps	96.35	2.00e-85	307.00
IUUC-Ont-071379	Oreochromis niloticus	80.07	9.00e-119	419.00
IUUC-Oan-073508	Ornithorhynchus anatinus	93.27	5.00e-58	216.00
IUUC-Ocu-074753	Oryctolagus cuniculus	89.42	2.00e-113	401.00
IUUC-Ola-086417	Oryzias latipes	80.87	4.00e-122	430.00
IUUC-Olu-087609	Ostreococcus lucimarinus	40.00	1.00e-03	37.00
IUUC-Oga-088770	Otolemur garnettii	85.19	2.00e-111	395.00
IUUC-Oar-089528	Ovis aries	53.65	6.00e-34	137.00
IUUC-Pan-091998	Papio anubis	89.74	4.00e-123	433.00
IUUC-Psi-093365	Pelodiscus sinensis	88.17	2.00e-114	404.00
IUUC-Pma-094505	Petromyzon marinus	52.21	5.00e-73	267.00
IUUC-Pfo-096152	Poecilia formosa	81.23	3.00e-123	434.00
IUUC-Pab-097752	Pongo abelii	89.74	4.00e-123	433.00
IUUC-Pop-099461	Populus trichocarpa	45.24	2.10e-01	29.60
IUUC-Pca-100823	Procavia capensis	78.73	1.00e-115	408.00
IUUC-Pva-102815	Pteropus vampyrus	86.96	6.00e-106	376.00
IUUC-Pyt-104628	Pyrenophora triticirepentis	41.18	5.80e-01	28.90
IUUC-Rno-105011	Rattus norvegicus	92.70	7.00e-125	439.00
IUUC-Sce-106317	Saccharomyces cerevisiae	35.42	2.80e-01	29.60
IUUC-Sha-107028	Sarcophilus harrisii	86.45	7.00e-69	252.00
IUUC-Ssl-108621	Sclerotinia sclerotiorum	36.84	5.80e-01	28.90
IUUC-Smo-109303	Selaginella moellendorffii	25.00	5.00e-08	49.30
IUUC-Stu-112916	Solanum tuberosum	30.33	2.00e-10	58.20
IUUC-Sar-113252	Sorex araneus	65.02	3.00e-42	164.00
IUUC-Sre-115062	Sporisorium reilianum	48.48	4.00e-04	39.70
IUUC-Ssc-116217	Sus scrofa	57.42	5.00e-55	207.00
IUUC-Tgu-116503	Taeniopygia guttata	88.32	1.00e-121	429.00
IUUC-Tru-118257	Takifugu rubripes	80.43	2.00e-121	428.00
IUUC-Tni-120576	Tetraodon nigroviridis	75.18	5.00e-110	390.00
IUUC-Tca-121166	Theobroma cacao	28.93	2.00e-06	46.20
IUUC-Tre-121981	Trichoderma reesei	38.24	6.50e-01	28.50
IUUC-Tbe-128094	Tupaia belangeri	89.58	3.00e-100	358.00
IUUC-Ttr-128957	Tursiops truncatus	99.18	1.00e-52	199.00
IUUC-Uma-129647	Ustilago maydis	41.07	2.00e-05	43.90
IUUC-Vda-129734	Verticillium dahliae	50.00	2.00e-03	37.40
IUUC-Xtr-132846	Xenopus tropicalis	80.88	1.00e-112	398.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence