iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003351

Ensembl Protein ID

ENSAPLP00000008470.1

UniProt Accession

U3IMJ7; U3IMJ7_ANAPL

Genbank Protein ID

ENSAPLP00000008470

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01030788

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000008760.1	ENSAPLT00000009150.1	ENSAPLP00000008470.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.20e-111	370.8	149	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPSSLSHGIKLVNPMFRGYA 232
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+                    d+ +++d+                                        
   Q: 233  QQDTQEFLRCLMDQLHEELKEpivaetrdL-----------DTGDQDDKregdrspsedeflscdsssdrgegdgqsrtagsvgsssla 310
           *******************77443332222...........3333333344456677777***************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 311  etelliqdeagrgisekermkdrkfscghrrsnseqvdedadvdttmmpvdgraspemlpaprpaspcrtpepdndayvrcssrpcspv 399
           ***************************************************************************************** PP
   S: 130  ..................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
                                              ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k
   Q: 400  hhemhsklssspprssparlgpsyvlkkaqmqasGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAK 488
           ********************************9999999999*******************************************9988 PP
   S: 185  e.................................................slqdcLesftkeeelegenkyycekckkkqeaekklklk 224
           +                                                 +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ 
   Q: 489  LhsaiyqnvpaktgacgdnyasqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVL 577
           8**************************************************************************************** PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdD 311
           +lPe+L++hLkRf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD
   Q: 578  RLPEILCIHLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDD 662
           *************..9999*************************99888..9**************************78999****** PP
   S: 312  skVtevkeeevleetgstaYvlfYkr 337
           ++Vtev+e+ v++   ++aYvlfY++
   Q: 663  QYVTEVHETVVQN---AEAYVLFYRK 685
           *************...********98 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

LVRMGDTRDI CPHLDSIGEV TRDDLLLKSK GTCQSCGAVG PNLWACLQQL GCSYVGCGES 60
FADHSTLHAQ AKKHNLTVNL TTFRVWCYAC EKEVFLDQRL AAHPQSPPVK FTEPNSPLPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGTGAGAA TGGGGGATAC AAGAGACATC TGTCCTCACC TGGATTCCAT AGGAGAGGTG 60
ACCAGGGATG ATCTGCTGCT CAAATCCAAG GTACAGGGTG TTCTGGTTGT CAGTCCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	83.95	0.00e+00	1534.00
IUUC-Aca-005077	Anolis carolinensis	80.24	0.00e+00	1155.00
IUUC-Ago-007836	Ashbya gossypii	32.70	2.00e-28	120.00
IUUC-Ame-011777	Astyanax mexicanus	75.56	0.00e+00	1353.00
IUUC-Bta-013063	Bos taurus	85.42	0.00e+00	1540.00
IUUC-Cja-019868	Callithrix jacchus	85.45	0.00e+00	1562.00
IUUC-Cfa-020761	Canis familiaris	84.67	0.00e+00	1553.00
IUUC-Cpo-022267	Cavia porcellus	80.89	0.00e+00	1457.00
IUUC-Csa-024251	Chlorocebus sabaeus	86.40	0.00e+00	1578.00
IUUC-Cho-024483	Choloepus hoffmanni	93.87	1.00e-121	430.00
IUUC-Dre-028061	Danio rerio	74.85	0.00e+00	1216.00
IUUC-Dno-029423	Dasypus novemcinctus	86.29	0.00e+00	1562.00
IUUC-Dor-030877	Dipodomys ordii	85.50	0.00e+00	1014.00
IUUC-Dme-031837	Drosophila melanogaster	48.94	7.00e-139	488.00
IUUC-Ete-032802	Echinops telfairi	73.94	3.00e-130	458.00
IUUC-Eca-034283	Equus caballus	84.58	0.00e+00	1549.00
IUUC-Eeu-034620	Erinaceus europaeus	82.58	0.00e+00	1082.00
IUUC-Fca-036357	Felis catus	85.33	0.00e+00	1535.00
IUUC-Fal-037411	Ficedula albicollis	97.48	0.00e+00	1770.00
IUUC-Gga-041101	Gallus gallus	96.17	0.00e+00	1761.00
IUUC-Gac-041315	Gasterosteus aculeatus	74.22	0.00e+00	1326.00
IUUC-Ggo-045600	Gorilla gorilla	86.18	0.00e+00	1532.00
IUUC-Hsa-045825	Homo sapiens	86.40	0.00e+00	1549.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	73.59	0.00e+00	1279.00
IUUC-Lch-050002	Latimeria chalumnae	77.73	0.00e+00	1364.00
IUUC-Loc-052574	Lepisosteus oculatus	78.10	0.00e+00	1415.00
IUUC-Laf-054428	Loxodonta africana	85.78	0.00e+00	1552.00
IUUC-Mcc-055736	Macaca mulatta	86.18	0.00e+00	1573.00
IUUC-Mga-059781	Meleagris gallopavo	95.77	0.00e+00	1768.00
IUUC-Mdo-063048	Monodelphis domestica	90.04	0.00e+00	1576.00
IUUC-Mmu-064079	Mus musculus	82.84	0.00e+00	1518.00
IUUC-Mpu-066616	Mustela putorius furo	84.38	0.00e+00	1585.00
IUUC-Mlu-067294	Myotis lucifugus	84.35	0.00e+00	1487.00
IUUC-Nle-070015	Nomascus leucogenys	86.62	0.00e+00	1541.00
IUUC-Opr-070328	Ochotona princeps	85.11	0.00e+00	1551.00
IUUC-Ont-071464	Oreochromis niloticus	76.06	0.00e+00	1321.00
IUUC-Oan-073259	Ornithorhynchus anatinus	81.17	0.00e+00	1377.00
IUUC-Ocu-074630	Oryctolagus cuniculus	82.41	0.00e+00	1484.00
IUUC-Ola-087240	Oryzias latipes	74.89	0.00e+00	1296.00
IUUC-Oga-088761	Otolemur garnettii	84.75	0.00e+00	1558.00
IUUC-Oar-089490	Ovis aries	81.82	0.00e+00	1407.00
IUUC-Ptr-091662	Pan troglodytes	86.29	0.00e+00	1547.00
IUUC-Pan-092199	Papio anubis	86.54	0.00e+00	1567.00
IUUC-Psi-093726	Pelodiscus sinensis	93.64	0.00e+00	1715.00
IUUC-Pma-094389	Petromyzon marinus	64.85	2.00e-100	358.00
IUUC-Pab-098632	Pongo abelii	86.18	0.00e+00	1541.00
IUUC-Pca-100614	Procavia capensis	79.26	0.00e+00	1203.00
IUUC-Pva-102922	Pteropus vampyrus	81.74	0.00e+00	869.00
IUUC-Rno-105215	Rattus norvegicus	82.72	0.00e+00	1516.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.12	3.00e-25	110.00
IUUC-Sha-106601	Sarcophilus harrisii	87.95	0.00e+00	1547.00
IUUC-Ssc-115533	Sus scrofa	83.85	0.00e+00	1521.00
IUUC-Tgu-117364	Taeniopygia guttata	97.36	0.00e+00	1722.00
IUUC-Tru-117770	Takifugu rubripes	74.81	0.00e+00	1310.00
IUUC-Tni-120001	Tetraodon nigroviridis	74.09	0.00e+00	1284.00
IUUC-Ttr-128732	Tursiops truncatus	85.33	0.00e+00	1548.00
IUUC-Xtr-132157	Xenopus tropicalis	77.74	0.00e+00	1391.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence