iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	8871400; 11387208

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	8.10e-06	26.7	294	333

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLld 40
           ++e+++++ v+MGFdr+++l+ Lr+   n++ +  ++Lld
   Q: 294  INEEIVQEVVNMGFDRNQVLESLRNRtQNDATVTYYLLLD 333
           589**********************659998877777776 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN11 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Involved in innate antiviral defenses.

Protein Sequence
(Fasta)

MDHSSNRFGN NGVESILPNY KLGKTLGIGS FGKVKIAEHV VTGHKVAIKI LNRRKIKNME 60
MEEKVRREIK ILRLFMHPHI IRQYEVIETT SDIYVVMEYV KSGELFDYIV EKGRLQEDEA 120

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Nucleotide Sequence
(Fasta)

AAATGGCAAT AAATGTTTAT CTGGGTTTTG TGGTTTCTTG ATTCGTCATT ACCAATTTTC 60
ACCATGAAGA CTTAAAAAAA CCTGACTCAG CTCTGCGTCA CCTACGAGTT GGAAATCTGA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0930--Antiviral protein
KW-0067--ATP-binding
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0945--Host-virus interaction
KW-0418--Kinase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0534--Nitrate assimilation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0005975--P:carbohydrate metabolic process
GO:0006633--P:fatty acid biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0042128--P:nitrate assimilation
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0050688--P:regulation of defense response to virus
GO:0016032--P:viral process

KEGG

ath:AT3G29160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005773	Arabidopsis lyrata	98.83	0.00e+00	1059.00
IUUC-Bci-013774	Botrytis cinerea	63.29	5.00e-101	361.00
IUUC-Bol-016434	Brassica oleracea	94.14	0.00e+00	1013.00
IUUC-Bra-016908	Brassica rapa	94.14	0.00e+00	1014.00
IUUC-Eeu-034949	Erinaceus europaeus	45.45	4.00e-80	291.00
IUUC-Meu-056705	Macropus eugenii	46.25	4.00e-82	298.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence